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LMNB1 (lamin B1)

Identity

Other aliasADLD
LMN
LMN2
LMNB
HGNC (Hugo) LMNB1
LocusID (NCBI) 4001
Atlas_Id 51411
Location 5q23.2  [Link to chromosome band 5q23]
Location_base_pair Starts at 126777153 and ends at 126837020 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANKRD28 (3p25.1) / LMNB1 (5q23.2)LMNB1 (5q23.2) / CALD1 (7q33)PCIF1 (20q13.12) / LMNB1 (5q23.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LMNB1   6637
Cards
Entrez_Gene (NCBI)LMNB1  4001  lamin B1
AliasesADLD; LMN; LMN2; LMNB
GeneCards (Weizmann)LMNB1
Ensembl hg19 (Hinxton)ENSG00000113368 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113368 [Gene_View]  chr5:126777153-126837020 [Contig_View]  LMNB1 [Vega]
ICGC DataPortalENSG00000113368
TCGA cBioPortalLMNB1
AceView (NCBI)LMNB1
Genatlas (Paris)LMNB1
WikiGenes4001
SOURCE (Princeton)LMNB1
Genetics Home Reference (NIH)LMNB1
Genomic and cartography
GoldenPath hg38 (UCSC)LMNB1  -     chr5:126777153-126837020 +  5q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LMNB1  -     5q23.2   [Description]    (hg19-Feb_2009)
EnsemblLMNB1 - 5q23.2 [CytoView hg19]  LMNB1 - 5q23.2 [CytoView hg38]
Mapping of homologs : NCBILMNB1 [Mapview hg19]  LMNB1 [Mapview hg38]
OMIM150340   169500   
Gene and transcription
Genbank (Entrez)AK303084 AK312603 AU134245 AW512433 BC012295
RefSeq transcript (Entrez)NM_001198557 NM_005573
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LMNB1
Cluster EST : UnigeneHs.89497 [ NCBI ]
CGAP (NCI)Hs.89497
Alternative Splicing GalleryENSG00000113368
Gene ExpressionLMNB1 [ NCBI-GEO ]   LMNB1 [ EBI - ARRAY_EXPRESS ]   LMNB1 [ SEEK ]   LMNB1 [ MEM ]
Gene Expression Viewer (FireBrowse)LMNB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4001
GTEX Portal (Tissue expression)LMNB1
Human Protein AtlasENSG00000113368-LMNB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20700   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20700  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20700
Splice isoforms : SwissVarP20700
PhosPhoSitePlusP20700
Domaine pattern : Prosite (Expaxy)IF (PS00226)   
Domains : Interpro (EBI)IF    Intermediate_filament_CS    Lamin_tail_dom   
Domain families : Pfam (Sanger)Filament (PF00038)    LTD (PF00932)   
Domain families : Pfam (NCBI)pfam00038    pfam00932   
Domain families : Smart (EMBL)Filament (SM01391)  
Conserved Domain (NCBI)LMNB1
DMDM Disease mutations4001
Blocks (Seattle)LMNB1
PDB (SRS)2KPW    3JT0    3TYY    3UMN   
PDB (PDBSum)2KPW    3JT0    3TYY    3UMN   
PDB (IMB)2KPW    3JT0    3TYY    3UMN   
PDB (RSDB)2KPW    3JT0    3TYY    3UMN   
Structural Biology KnowledgeBase2KPW    3JT0    3TYY    3UMN   
SCOP (Structural Classification of Proteins)2KPW    3JT0    3TYY    3UMN   
CATH (Classification of proteins structures)2KPW    3JT0    3TYY    3UMN   
SuperfamilyP20700
Human Protein Atlas [tissue]ENSG00000113368-LMNB1 [tissue]
Peptide AtlasP20700
HPRD01036
IPIIPI00217975   IPI00984399   IPI00790831   
Protein Interaction databases
DIP (DOE-UCLA)P20700
IntAct (EBI)P20700
FunCoupENSG00000113368
BioGRIDLMNB1
STRING (EMBL)LMNB1
ZODIACLMNB1
Ontologies - Pathways
QuickGOP20700
Ontology : AmiGOstructural molecule activity  protein binding  nucleus  nuclear envelope  nuclear inner membrane  lamin filament  nucleoplasm  membrane  nuclear matrix  nuclear membrane  phospholipase binding  
Ontology : EGO-EBIstructural molecule activity  protein binding  nucleus  nuclear envelope  nuclear inner membrane  lamin filament  nucleoplasm  membrane  nuclear matrix  nuclear membrane  phospholipase binding  
Pathways : BIOCARTAFAS signaling pathway ( CD95 ) [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    TNFR1 Signaling Pathway [Genes]    Caspase Cascade in Apoptosis [Genes]   
NDEx NetworkLMNB1
Atlas of Cancer Signalling NetworkLMNB1
Wikipedia pathwaysLMNB1
Orthology - Evolution
OrthoDB4001
GeneTree (enSembl)ENSG00000113368
Phylogenetic Trees/Animal Genes : TreeFamLMNB1
HOVERGENP20700
HOGENOMP20700
Homologs : HomoloGeneLMNB1
Homology/Alignments : Family Browser (UCSC)LMNB1
Gene fusions - Rearrangements
Tumor Fusion PortalLMNB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLMNB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LMNB1
dbVarLMNB1
ClinVarLMNB1
1000_GenomesLMNB1 
Exome Variant ServerLMNB1
ExAC (Exome Aggregation Consortium)ENSG00000113368
GNOMAD BrowserENSG00000113368
Genetic variants : HAPMAP4001
Genomic Variants (DGV)LMNB1 [DGVbeta]
DECIPHERLMNB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLMNB1 
Mutations
ICGC Data PortalLMNB1 
TCGA Data PortalLMNB1 
Broad Tumor PortalLMNB1
OASIS PortalLMNB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLMNB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLMNB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch LMNB1
DgiDB (Drug Gene Interaction Database)LMNB1
DoCM (Curated mutations)LMNB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LMNB1 (select a term)
intoGenLMNB1
Cancer3DLMNB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM150340    169500   
Orphanet14044   
DisGeNETLMNB1
MedgenLMNB1
Genetic Testing Registry LMNB1
NextProtP20700 [Medical]
TSGene4001
GENETestsLMNB1
Target ValidationLMNB1
Huge Navigator LMNB1 [HugePedia]
snp3D : Map Gene to Disease4001
BioCentury BCIQLMNB1
ClinGenLMNB1 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4001
Chemical/Pharm GKB GenePA30403
Clinical trialLMNB1
Miscellaneous
canSAR (ICR)LMNB1 (select the gene name)
Probes
Litterature
PubMed145 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLMNB1
EVEXLMNB1
GoPubMedLMNB1
iHOPLMNB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:20:09 CET 2017

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