LMNB1 (lamin B1)

2010-04-01  

Identity

HGNC
LOCATION
5q23.2
LOCUSID
ALIAS
ADLD,LMN,LMN2,LMNB,MCPH26
FUSION GENES

Other Information

Locus ID:

NCBI: 4001
MIM: 150340
HGNC: 6637
Ensembl: ENSG00000113368

Variants:

dbSNP: 4001
ClinVar: 4001
TCGA: ENSG00000113368
COSMIC: LMNB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113368ENST00000261366P20700
ENSG00000113368ENST00000395354E9PBF6
ENSG00000113368ENST00000460265A0A0D9SFE5
ENSG00000113368ENST00000492190A0A0D9SFY5

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
ApoptosisKEGGhsa04210
DiseaseREACTOMER-HSA-1643685
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Nuclear Envelope BreakdownREACTOMER-HSA-2980766
Depolymerisation of the Nuclear LaminaREACTOMER-HSA-4419969
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Nuclear Envelope ReassemblyREACTOMER-HSA-2995410
Initiation of Nuclear Envelope ReformationREACTOMER-HSA-2995383
MeiosisREACTOMER-HSA-1500620
Meiotic synapsisREACTOMER-HSA-1221632
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465
Breakdown of the nuclear laminaREACTOMER-HSA-352238
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
Formation of Senescence-Associated Heterochromatin Foci (SAHF)REACTOMER-HSA-2559584
Neurodegenerative DiseasesREACTOMER-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsREACTOMER-HSA-8862803

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191414742008The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription.200
224964212012Lamin B1 loss is a senescence-associated biomarker.189
239346582013Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape.157
221559252011The role of nuclear lamin B1 in cell proliferation and senescence.145
165434172006A mitotic lamin B matrix induced by RanGTP required for spindle assembly.139
239640942013Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence.77
222461862012Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation.72
234396832013Lamin B1 fluctuations have differential effects on cellular proliferation and senescence.62
191986022009Requirement for Nudel and dynein for assembly of the lamin B spindle matrix.57
183345542008The integrity of a lamin-B1-dependent nucleoskeleton is a fundamental determinant of RNA synthesis in human cells.47

Citation

Dessen P

LMNB1 (lamin B1)

Atlas Genet Cytogenet Oncol Haematol. 2010-04-01

Online version: http://atlasgeneticsoncology.org/gene/51411/lmnb1