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LMO3 (LIM domain only 3)

Identity

Alias_namesRBTNL2
rhombotin-like 2
Alias_symbol (synonym)Rhom-3
DAT1
Other aliasRBTN3
RHOM3
HGNC (Hugo) LMO3
LocusID (NCBI) 55885
Atlas_Id 418
Location 12p12.3  [Link to chromosome band 12p12]
Location_base_pair Starts at 16548372 and ends at 16606602 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MOSPD3 (7q22.1) / LMO3 (12p12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(7;11)(q34;p15) TRB/LMO1::t(11;14)(p15;q11) TRD/LMO1

External links

Nomenclature
HGNC (Hugo)LMO3   6643
Cards
Entrez_Gene (NCBI)LMO3  55885  LIM domain only 3
AliasesRBTN3; RBTNL2; RHOM3; Rhom-3
GeneCards (Weizmann)LMO3
Ensembl hg19 (Hinxton)ENSG00000048540 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000048540 [Gene_View]ENSG00000048540 [Sequence]  chr12:16548372-16606602 [Contig_View]  LMO3 [Vega]
ICGC DataPortalENSG00000048540
TCGA cBioPortalLMO3
AceView (NCBI)LMO3
Genatlas (Paris)LMO3
WikiGenes55885
SOURCE (Princeton)LMO3
Genetics Home Reference (NIH)LMO3
Genomic and cartography
GoldenPath hg38 (UCSC)LMO3  -     chr12:16548372-16606602 -  12p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LMO3  -     12p12.3   [Description]    (hg19-Feb_2009)
EnsemblLMO3 - 12p12.3 [CytoView hg19]  LMO3 - 12p12.3 [CytoView hg38]
Mapping of homologs : NCBILMO3 [Mapview hg19]  LMO3 [Mapview hg38]
OMIM180386   
Gene and transcription
Genbank (Entrez)AB044745 AB044746 AF258348 AK095595 AK294474
RefSeq transcript (Entrez)NM_001001395 NM_001243609 NM_001243610 NM_001243611 NM_001243612 NM_001243613 NM_018640
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LMO3
Cluster EST : UnigeneHs.504908 [ NCBI ]
CGAP (NCI)Hs.504908
Alternative Splicing GalleryENSG00000048540
Gene ExpressionLMO3 [ NCBI-GEO ]   LMO3 [ EBI - ARRAY_EXPRESS ]   LMO3 [ SEEK ]   LMO3 [ MEM ]
Gene Expression Viewer (FireBrowse)LMO3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55885
GTEX Portal (Tissue expression)LMO3
Human Protein AtlasENSG00000048540-LMO3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TAP4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TAP4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TAP4
Splice isoforms : SwissVarQ8TAP4
PhosPhoSitePlusQ8TAP4
Domaine pattern : Prosite (Expaxy)LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)   
Domains : Interpro (EBI)Znf_LIM   
Domain families : Pfam (Sanger)LIM (PF00412)   
Domain families : Pfam (NCBI)pfam00412   
Domain families : Smart (EMBL)LIM (SM00132)  
Conserved Domain (NCBI)LMO3
DMDM Disease mutations55885
Blocks (Seattle)LMO3
SuperfamilyQ8TAP4
Human Protein Atlas [tissue]ENSG00000048540-LMO3 [tissue]
Peptide AtlasQ8TAP4
HPRD11832
IPIIPI00744307   IPI00910185   IPI00032844   IPI00152081   IPI01022999   IPI00794072   IPI01014323   IPI00939181   IPI00910181   IPI01011541   IPI01010126   IPI01015503   IPI01009856   IPI01014802   IPI01015877   
Protein Interaction databases
DIP (DOE-UCLA)Q8TAP4
IntAct (EBI)Q8TAP4
FunCoupENSG00000048540
BioGRIDLMO3
STRING (EMBL)LMO3
ZODIACLMO3
Ontologies - Pathways
QuickGOQ8TAP4
Ontology : AmiGOprotein binding  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  positive regulation of peroxisome proliferator activated receptor signaling pathway  positive regulation of fat cell differentiation  metal ion binding  negative regulation of ERK1 and ERK2 cascade  positive regulation of glucocorticoid receptor signaling pathway  
Ontology : EGO-EBIprotein binding  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  positive regulation of peroxisome proliferator activated receptor signaling pathway  positive regulation of fat cell differentiation  metal ion binding  negative regulation of ERK1 and ERK2 cascade  positive regulation of glucocorticoid receptor signaling pathway  
NDEx NetworkLMO3
Atlas of Cancer Signalling NetworkLMO3
Wikipedia pathwaysLMO3
Orthology - Evolution
OrthoDB55885
GeneTree (enSembl)ENSG00000048540
Phylogenetic Trees/Animal Genes : TreeFamLMO3
HOVERGENQ8TAP4
HOGENOMQ8TAP4
Homologs : HomoloGeneLMO3
Homology/Alignments : Family Browser (UCSC)LMO3
Gene fusions - Rearrangements
Fusion : QuiverLMO3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLMO3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LMO3
dbVarLMO3
ClinVarLMO3
1000_GenomesLMO3 
Exome Variant ServerLMO3
ExAC (Exome Aggregation Consortium)ENSG00000048540
GNOMAD BrowserENSG00000048540
Genetic variants : HAPMAP55885
Genomic Variants (DGV)LMO3 [DGVbeta]
DECIPHERLMO3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLMO3 
Mutations
ICGC Data PortalLMO3 
TCGA Data PortalLMO3 
Broad Tumor PortalLMO3
OASIS PortalLMO3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLMO3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLMO3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LMO3
DgiDB (Drug Gene Interaction Database)LMO3
DoCM (Curated mutations)LMO3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LMO3 (select a term)
intoGenLMO3
Cancer3DLMO3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180386   
Orphanet
DisGeNETLMO3
MedgenLMO3
Genetic Testing Registry LMO3
NextProtQ8TAP4 [Medical]
TSGene55885
GENETestsLMO3
Target ValidationLMO3
Huge Navigator LMO3 [HugePedia]
snp3D : Map Gene to Disease55885
BioCentury BCIQLMO3
ClinGenLMO3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55885
Chemical/Pharm GKB GenePA30409
Clinical trialLMO3
Miscellaneous
canSAR (ICR)LMO3 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLMO3
EVEXLMO3
GoPubMedLMO3
iHOPLMO3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jun 21 16:58:24 CEST 2018
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