LMTK3 (lemur tyrosine kinase 3)

2011-09-01  

Identity

HGNC
LMTK3
LOCATION
19q13.33
LOCUSID
114783
ALIAS
LMR3,PPP1R101,TYKLM3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 114783
HGNC: 19295
Ensembl: ENSG00000142235

Variants:

dbSNP: 114783
ClinVar: 114783
TCGA: ENSG00000142235
COSMIC: LMTK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142235ENST00000270238A0A0A0MQW5
ENSG00000142235ENST00000600059Q96Q04
ENSG00000142235ENST00000647709A0A3B3IRV9
ENSG00000142235ENST00000648216A0A3B3ITQ7
ENSG00000142235ENST00000650440A0A3B3ISL5

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
345163512021Lemur tyrosine kinase-3 (LMTK3) induces chemoresistance to cetuximab in colorectal cancer via the ERK/MAPK pathway.2
345163512021Lemur tyrosine kinase-3 (LMTK3) induces chemoresistance to cetuximab in colorectal cancer via the ERK/MAPK pathway.2
328658712020LMTK3 promotes tumorigenesis in bladder cancer via the ERK/MAPK pathway.8
328658712020LMTK3 promotes tumorigenesis in bladder cancer via the ERK/MAPK pathway.8
302422442019LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma.12
309440272019The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1.29
302422442019LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma.12
309440272019The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1.29
295408292018LMTK3 confers chemo-resistance in breast cancer.18
295408292018LMTK3 confers chemo-resistance in breast cancer.18
282600522017LMTK3 knockdown retards cell growth and invasion and promotes apoptosis in thyroid cancer.7
282941152017Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.29
288481132017Lemur Tyrosine Kinase-3 Suppresses Growth of Prostate Cancer Via the AKT and MAPK Signaling Pathways.6
282600522017LMTK3 knockdown retards cell growth and invasion and promotes apoptosis in thyroid cancer.7
282941152017Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.29

Citation

Dessen P

LMTK3 (lemur tyrosine kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2011-09-01

Online version: http://atlasgeneticsoncology.org/gene/43602/lmtk3