LMTK3 (lemur tyrosine kinase 3)

2011-09-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
LMR3,PPP1R101,TYKLM3
FUSION GENES

Other Information

Locus ID:

NCBI: 114783
HGNC: 19295
Ensembl: ENSG00000142235

Variants:

dbSNP: 114783
ClinVar: 114783
TCGA: ENSG00000142235
COSMIC: LMTK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142235ENST00000270238A0A0A0MQW5
ENSG00000142235ENST00000600059Q96Q04
ENSG00000142235ENST00000647709A0A3B3IRV9
ENSG00000142235ENST00000648216A0A3B3ITQ7
ENSG00000142235ENST00000650440A0A3B3ISL5

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
216028042011Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer.40
240507762013MicroRNA-34a suppresses cell proliferation by targeting LMTK3 in human breast cancer mcf-7 cell line.19
228691492013LMTK3 is implicated in endocrine resistance via multiple signaling pathways.16
249398942014The kinase LMTK3 promotes invasion in breast cancer through GRB2-mediated induction of integrin β₁.12
216710152012LMTK3 expression in breast cancer: association with tumor phenotype and clinical outcome.11
282941152017Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.9
267390632016LMTK3 escapes tumour suppressor miRNAs via sequestration of DDX5.8
239188322013Prognostic role of lemur tyrosine kinase-3 germline polymorphisms in adjuvant gastric cancer in Japan and the United States.6
241743172013Serum lemur tyrosine kinase 3 expression in colorectal cancer patients predicts cancer progression and prognosis.6
309440272019The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1.6

Citation

Dessen P

LMTK3 (lemur tyrosine kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2011-09-01

Online version: http://atlasgeneticsoncology.org/gene/43602/lmtk3