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LNPEP (leucyl and cystinyl aminopeptidase)

Identity

Alias_namesleucyl/cystinyl aminopeptidase
Alias_symbol (synonym)CAP
PLAP
P-LAP
IRAP
Other alias
HGNC (Hugo) LNPEP
LocusID (NCBI) 4012
Atlas_Id 43606
Location 5q15  [Link to chromosome band 5q15]
Location_base_pair Starts at 96935642 and ends at 97029411 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LNPEP (5q15) / CAST (5q15)RASGEF1B (4q21.21) / LNPEP (5q15)LNPEP 5q15 / CAST 5q15

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LNPEP   6656
Cards
Entrez_Gene (NCBI)LNPEP  4012  leucyl and cystinyl aminopeptidase
AliasesCAP; IRAP; P-LAP; PLAP
GeneCards (Weizmann)LNPEP
Ensembl hg19 (Hinxton)ENSG00000113441 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113441 [Gene_View]  chr5:96935642-97029411 [Contig_View]  LNPEP [Vega]
ICGC DataPortalENSG00000113441
TCGA cBioPortalLNPEP
AceView (NCBI)LNPEP
Genatlas (Paris)LNPEP
WikiGenes4012
SOURCE (Princeton)LNPEP
Genetics Home Reference (NIH)LNPEP
Genomic and cartography
GoldenPath hg38 (UCSC)LNPEP  -     chr5:96935642-97029411 +  5q15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LNPEP  -     5q15   [Description]    (hg19-Feb_2009)
EnsemblLNPEP - 5q15 [CytoView hg19]  LNPEP - 5q15 [CytoView hg38]
Mapping of homologs : NCBILNPEP [Mapview hg19]  LNPEP [Mapview hg38]
OMIM151300   
Gene and transcription
Genbank (Entrez)AB208883 AK096804 AK314226 BC028692 BC111718
RefSeq transcript (Entrez)NM_005575 NM_175920
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LNPEP
Cluster EST : UnigeneHs.656905 [ NCBI ]
CGAP (NCI)Hs.656905
Alternative Splicing GalleryENSG00000113441
Gene ExpressionLNPEP [ NCBI-GEO ]   LNPEP [ EBI - ARRAY_EXPRESS ]   LNPEP [ SEEK ]   LNPEP [ MEM ]
Gene Expression Viewer (FireBrowse)LNPEP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4012
GTEX Portal (Tissue expression)LNPEP
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UIQ6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UIQ6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UIQ6
Splice isoforms : SwissVarQ9UIQ6
Catalytic activity : Enzyme3.4.11.3 [ Enzyme-Expasy ]   3.4.11.33.4.11.3 [ IntEnz-EBI ]   3.4.11.3 [ BRENDA ]   3.4.11.3 [ KEGG ]   
PhosPhoSitePlusQ9UIQ6
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Cystinyl_aminopeptidase    ERAP1-like_C_dom    M1_APN-typ    Peptidase_M1    Peptidase_M1_N   
Domain families : Pfam (Sanger)ERAP1_C (PF11838)    Peptidase_M1 (PF01433)   
Domain families : Pfam (NCBI)pfam11838    pfam01433   
Conserved Domain (NCBI)LNPEP
DMDM Disease mutations4012
Blocks (Seattle)LNPEP
PDB (SRS)4P8Q    4PJ6    4Z7I    5C97    5JHQ   
PDB (PDBSum)4P8Q    4PJ6    4Z7I    5C97    5JHQ   
PDB (IMB)4P8Q    4PJ6    4Z7I    5C97    5JHQ   
PDB (RSDB)4P8Q    4PJ6    4Z7I    5C97    5JHQ   
Structural Biology KnowledgeBase4P8Q    4PJ6    4Z7I    5C97    5JHQ   
SCOP (Structural Classification of Proteins)4P8Q    4PJ6    4Z7I    5C97    5JHQ   
CATH (Classification of proteins structures)4P8Q    4PJ6    4Z7I    5C97    5JHQ   
SuperfamilyQ9UIQ6
Human Protein AtlasENSG00000113441
Peptide AtlasQ9UIQ6
HPRD01041
IPIIPI00307017   IPI00221240   IPI00221241   
Protein Interaction databases
DIP (DOE-UCLA)Q9UIQ6
IntAct (EBI)Q9UIQ6
FunCoupENSG00000113441
BioGRIDLNPEP
STRING (EMBL)LNPEP
ZODIACLNPEP
Ontologies - Pathways
QuickGOQ9UIQ6
Ontology : AmiGOprotein polyubiquitination  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent  aminopeptidase activity  aminopeptidase activity  protein binding  extracellular region  intracellular  lysosomal membrane  cytosol  plasma membrane  integral component of plasma membrane  proteolysis  signal transduction  cell-cell signaling  female pregnancy  regulation of blood pressure  metallopeptidase activity  zinc ion binding  membrane  protein catabolic process  cytoplasmic vesicle membrane  early endosome lumen  peptide binding  peptide catabolic process  perinuclear region of cytoplasm  SMAD protein signal transduction  membrane organization  metalloaminopeptidase activity  
Ontology : EGO-EBIprotein polyubiquitination  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent  aminopeptidase activity  aminopeptidase activity  protein binding  extracellular region  intracellular  lysosomal membrane  cytosol  plasma membrane  integral component of plasma membrane  proteolysis  signal transduction  cell-cell signaling  female pregnancy  regulation of blood pressure  metallopeptidase activity  zinc ion binding  membrane  protein catabolic process  cytoplasmic vesicle membrane  early endosome lumen  peptide binding  peptide catabolic process  perinuclear region of cytoplasm  SMAD protein signal transduction  membrane organization  metalloaminopeptidase activity  
Pathways : KEGGRenin-angiotensin system   
NDEx NetworkLNPEP
Atlas of Cancer Signalling NetworkLNPEP
Wikipedia pathwaysLNPEP
Orthology - Evolution
OrthoDB4012
GeneTree (enSembl)ENSG00000113441
Phylogenetic Trees/Animal Genes : TreeFamLNPEP
HOVERGENQ9UIQ6
HOGENOMQ9UIQ6
Homologs : HomoloGeneLNPEP
Homology/Alignments : Family Browser (UCSC)LNPEP
Gene fusions - Rearrangements
Fusion: TCGALNPEP 5q15 CAST 5q15 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLNPEP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LNPEP
dbVarLNPEP
ClinVarLNPEP
1000_GenomesLNPEP 
Exome Variant ServerLNPEP
ExAC (Exome Aggregation Consortium)LNPEP (select the gene name)
Genetic variants : HAPMAP4012
Genomic Variants (DGV)LNPEP [DGVbeta]
DECIPHERLNPEP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLNPEP 
Mutations
ICGC Data PortalLNPEP 
TCGA Data PortalLNPEP 
Broad Tumor PortalLNPEP
OASIS PortalLNPEP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLNPEP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLNPEP
intOGen PortalLNPEP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LNPEP
DgiDB (Drug Gene Interaction Database)LNPEP
DoCM (Curated mutations)LNPEP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LNPEP (select a term)
intoGenLNPEP
Cancer3DLNPEP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM151300   
Orphanet
MedgenLNPEP
Genetic Testing Registry LNPEP
NextProtQ9UIQ6 [Medical]
TSGene4012
GENETestsLNPEP
Huge Navigator LNPEP [HugePedia]
snp3D : Map Gene to Disease4012
BioCentury BCIQLNPEP
ClinGenLNPEP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4012
Chemical/Pharm GKB GenePA30418
Clinical trialLNPEP
Miscellaneous
canSAR (ICR)LNPEP (select the gene name)
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLNPEP
EVEXLNPEP
GoPubMedLNPEP
iHOPLNPEP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:22:47 CEST 2017

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