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LNX1 (ligand of numb-protein X 1)

Identity

Alias (NCBI)LNX
MPDZ
PDZRN2
HGNC (Hugo) LNX1
HGNC Alias symbMPDZ
PDZRN2
HGNC Previous nameLNX
HGNC Previous nameligand of numb-protein X
 ligand of numb-protein X 1, E3 ubiquitin protein ligase
LocusID (NCBI) 84708
Atlas_Id 46071
Location 4q12  [Link to chromosome band 4q12]
Location_base_pair Starts at 53460270 and ends at 53558269 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KLHL5 (4p14) / LNX1 (4q12)LNX1 (4q12) / GABRB1 (4p12)KLHL5 4p14 / LNX1 4q12
LNX1 4q12 / GABRB1 4p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(4)(q12q12) FIP1L1/PDGFRA


External links

Nomenclature
HGNC (Hugo)LNX1   6657
Cards
Entrez_Gene (NCBI)LNX1    ligand of numb-protein X 1
AliasesLNX; MPDZ; PDZRN2
GeneCards (Weizmann)LNX1
Ensembl hg19 (Hinxton)ENSG00000072201 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000072201 [Gene_View]  ENSG00000072201 [Sequence]  chr4:53460270-53558269 [Contig_View]  LNX1 [Vega]
ICGC DataPortalENSG00000072201
TCGA cBioPortalLNX1
AceView (NCBI)LNX1
Genatlas (Paris)LNX1
SOURCE (Princeton)LNX1
Genetics Home Reference (NIH)LNX1
Genomic and cartography
GoldenPath hg38 (UCSC)LNX1  -     chr4:53460270-53558269 -  4q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LNX1  -     4q12   [Description]    (hg19-Feb_2009)
GoldenPathLNX1 - 4q12 [CytoView hg19]  LNX1 - 4q12 [CytoView hg38]
ImmunoBaseENSG00000072201
genome Data Viewer NCBILNX1 [Mapview hg19]  
OMIM609732   
Gene and transcription
Genbank (Entrez)AF237782 AK056823 AK294611 AY358326 BC022983
RefSeq transcript (Entrez)NM_001126328 NM_032622
Consensus coding sequences : CCDS (NCBI)LNX1
Alternative Splicing GalleryENSG00000072201
Gene ExpressionLNX1 [ NCBI-GEO ]   LNX1 [ EBI - ARRAY_EXPRESS ]   LNX1 [ SEEK ]   LNX1 [ MEM ]
Gene Expression Viewer (FireBrowse)LNX1 [ Firebrowse - Broad ]
GenevisibleExpression of LNX1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84708
GTEX Portal (Tissue expression)LNX1
Human Protein AtlasENSG00000072201-LNX1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TBB1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TBB1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TBB1
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ8TBB1
Domaine pattern : Prosite (Expaxy)PDZ (PS50106)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)PDZ    PDZ_sf    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam00595   
Domain families : Smart (EMBL)PDZ (SM00228)  RING (SM00184)  
Conserved Domain (NCBI)LNX1
PDB (RSDB)3B76    5H7R    5H7S   
PDB Europe3B76    5H7R    5H7S   
PDB (PDBSum)3B76    5H7R    5H7S   
PDB (IMB)3B76    5H7R    5H7S   
Structural Biology KnowledgeBase3B76    5H7R    5H7S   
SCOP (Structural Classification of Proteins)3B76    5H7R    5H7S   
CATH (Classification of proteins structures)3B76    5H7R    5H7S   
SuperfamilyQ8TBB1
AlphaFold pdb e-kbQ8TBB1   
Human Protein Atlas [tissue]ENSG00000072201-LNX1 [tissue]
HPRD17287
Protein Interaction databases
DIP (DOE-UCLA)Q8TBB1
IntAct (EBI)Q8TBB1
BioGRIDLNX1
STRING (EMBL)LNX1
ZODIACLNX1
Ontologies - Pathways
QuickGOQ8TBB1
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  cytoplasm  ubiquitin-dependent protein catabolic process  protein ubiquitination  PDZ domain binding  identical protein binding  metal ion binding  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  cytoplasm  ubiquitin-dependent protein catabolic process  protein ubiquitination  PDZ domain binding  identical protein binding  metal ion binding  
NDEx NetworkLNX1
Atlas of Cancer Signalling NetworkLNX1
Wikipedia pathwaysLNX1
Orthology - Evolution
OrthoDB84708
GeneTree (enSembl)ENSG00000072201
Phylogenetic Trees/Animal Genes : TreeFamLNX1
Homologs : HomoloGeneLNX1
Homology/Alignments : Family Browser (UCSC)LNX1
Gene fusions - Rearrangements
Fusion PortalKLHL5 4p14 LNX1 4q12 BLCA
Fusion PortalLNX1 4q12 GABRB1 4p12 BRCA
Fusion : QuiverLNX1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLNX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LNX1
dbVarLNX1
ClinVarLNX1
MonarchLNX1
1000_GenomesLNX1 
Exome Variant ServerLNX1
GNOMAD BrowserENSG00000072201
Varsome BrowserLNX1
Genomic Variants (DGV)LNX1 [DGVbeta]
DECIPHERLNX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLNX1 
Mutations
ICGC Data PortalLNX1 
TCGA Data PortalLNX1 
Broad Tumor PortalLNX1
OASIS PortalLNX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLNX1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLNX1
Mutations and Diseases : HGMDLNX1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutasearch LNX1
DgiDB (Drug Gene Interaction Database)LNX1
DoCM (Curated mutations)LNX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LNX1 (select a term)
Cancer3DLNX1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609732   
Orphanet
DisGeNETLNX1
MedgenLNX1
Genetic Testing Registry LNX1
NextProtQ8TBB1 [Medical]
GENETestsLNX1
Target ValidationLNX1
Huge Navigator LNX1 [HugePedia]
ClinGenLNX1
Clinical trials, drugs, therapy
MyCancerGenomeLNX1
Protein Interactions : CTDLNX1
Pharm GKB GenePA30419
PharosQ8TBB1
Clinical trialLNX1
Miscellaneous
canSAR (ICR)LNX1
HarmonizomeLNX1
DataMed IndexLNX1
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLNX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Sep 15 22:21:28 CEST 2021

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