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LNX1 (ligand of numb-protein X 1)

Identity

Alias_namesLNX
ligand of numb-protein X
ligand of numb-protein X 1, E3 ubiquitin protein ligase
Alias_symbol (synonym)MPDZ
PDZRN2
Other alias
HGNC (Hugo) LNX1
LocusID (NCBI) 84708
Atlas_Id 46071
Location 4q12  [Link to chromosome band 4q12]
Location_base_pair Starts at 54326437 and ends at 54457753 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KLHL5 (4p14) / LNX1 (4q12)LNX1 (4q12) / GABRB1 (4p12)KLHL5 4p14 / LNX1 4q12
LNX1 4q12 / GABRB1 4p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(4)(q12q12) FIP1L1/PDGFRA


External links

Nomenclature
HGNC (Hugo)LNX1   6657
Cards
Entrez_Gene (NCBI)LNX1  84708  ligand of numb-protein X 1
AliasesLNX; MPDZ; PDZRN2
GeneCards (Weizmann)LNX1
Ensembl hg19 (Hinxton)ENSG00000072201 [Gene_View]  chr4:54326437-54457753 [Contig_View]  LNX1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000072201 [Gene_View]  chr4:54326437-54457753 [Contig_View]  LNX1 [Vega]
ICGC DataPortalENSG00000072201
TCGA cBioPortalLNX1
AceView (NCBI)LNX1
Genatlas (Paris)LNX1
WikiGenes84708
SOURCE (Princeton)LNX1
Genetics Home Reference (NIH)LNX1
Genomic and cartography
GoldenPath hg19 (UCSC)LNX1  -     chr4:54326437-54457753 -  4q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LNX1  -     4q12   [Description]    (hg38-Dec_2013)
EnsemblLNX1 - 4q12 [CytoView hg19]  LNX1 - 4q12 [CytoView hg38]
Mapping of homologs : NCBILNX1 [Mapview hg19]  LNX1 [Mapview hg38]
OMIM609732   
Gene and transcription
Genbank (Entrez)AF237782 AK056823 AK294611 AY358326 BC022983
RefSeq transcript (Entrez)NM_001126328 NM_032622
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_022853 NW_004929319
Consensus coding sequences : CCDS (NCBI)LNX1
Cluster EST : UnigeneHs.518760 [ NCBI ]
CGAP (NCI)Hs.518760
Alternative Splicing GalleryENSG00000072201
Gene ExpressionLNX1 [ NCBI-GEO ]   LNX1 [ EBI - ARRAY_EXPRESS ]   LNX1 [ SEEK ]   LNX1 [ MEM ]
Gene Expression Viewer (FireBrowse)LNX1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84708
GTEX Portal (Tissue expression)LNX1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TBB1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TBB1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TBB1
Splice isoforms : SwissVarQ8TBB1
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusQ8TBB1
Domaine pattern : Prosite (Expaxy)PDZ (PS50106)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)PDZ    Znf_C3HC4_RING-type    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)PDZ (PF00595)    zf-C3HC4 (PF00097)   
Domain families : Pfam (NCBI)pfam00595    pfam00097   
Domain families : Smart (EMBL)PDZ (SM00228)  RING (SM00184)  
Conserved Domain (NCBI)LNX1
DMDM Disease mutations84708
Blocks (Seattle)LNX1
PDB (SRS)3B76   
PDB (PDBSum)3B76   
PDB (IMB)3B76   
PDB (RSDB)3B76   
Structural Biology KnowledgeBase3B76   
SCOP (Structural Classification of Proteins)3B76   
CATH (Classification of proteins structures)3B76   
SuperfamilyQ8TBB1
Human Protein AtlasENSG00000072201
Peptide AtlasQ8TBB1
HPRD17287
IPIIPI00152181   IPI00305598   IPI01009666   IPI00967553   IPI00967288   IPI00968256   IPI00966985   IPI00968006   
Protein Interaction databases
DIP (DOE-UCLA)Q8TBB1
IntAct (EBI)Q8TBB1
FunCoupENSG00000072201
BioGRIDLNX1
STRING (EMBL)LNX1
ZODIACLNX1
Ontologies - Pathways
QuickGOQ8TBB1
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  cytoplasm  zinc ion binding  ligase activity  PDZ domain binding  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  protein homooligomerization  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  cytoplasm  zinc ion binding  ligase activity  PDZ domain binding  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  protein homooligomerization  
NDEx NetworkLNX1
Atlas of Cancer Signalling NetworkLNX1
Wikipedia pathwaysLNX1
Orthology - Evolution
OrthoDB84708
GeneTree (enSembl)ENSG00000072201
Phylogenetic Trees/Animal Genes : TreeFamLNX1
HOVERGENQ8TBB1
HOGENOMQ8TBB1
Homologs : HomoloGeneLNX1
Homology/Alignments : Family Browser (UCSC)LNX1
Gene fusions - Rearrangements
Fusion: TCGAKLHL5 4p14 LNX1 4q12 BLCA
Fusion: TCGALNX1 4q12 GABRB1 4p12 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLNX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LNX1
dbVarLNX1
ClinVarLNX1
1000_GenomesLNX1 
Exome Variant ServerLNX1
ExAC (Exome Aggregation Consortium)LNX1 (select the gene name)
Genetic variants : HAPMAP84708
Genomic Variants (DGV)LNX1 [DGVbeta]
DECIPHER (Syndromes)4:54326437-54457753  ENSG00000072201
CONAN: Copy Number AnalysisLNX1 
Mutations
ICGC Data PortalLNX1 
TCGA Data PortalLNX1 
Broad Tumor PortalLNX1
OASIS PortalLNX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLNX1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLNX1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LNX1
DgiDB (Drug Gene Interaction Database)LNX1
DoCM (Curated mutations)LNX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LNX1 (select a term)
intoGenLNX1
Cancer3DLNX1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609732   
Orphanet
MedgenLNX1
Genetic Testing Registry LNX1
NextProtQ8TBB1 [Medical]
TSGene84708
GENETestsLNX1
Huge Navigator LNX1 [HugePedia]
snp3D : Map Gene to Disease84708
BioCentury BCIQLNX1
ClinGenLNX1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84708
Chemical/Pharm GKB GenePA30419
Clinical trialLNX1
Miscellaneous
canSAR (ICR)LNX1 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLNX1
EVEXLNX1
GoPubMedLNX1
iHOPLNX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:07:17 CEST 2017

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