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LNX2 (ligand of numb-protein X 2)

Identity

Alias_namesPDZRN1
PDZ domain containing ring finger 1
Alias_symbol (synonym)MGC46315
Other alias
HGNC (Hugo) LNX2
LocusID (NCBI) 222484
Atlas_Id 47042
Location 13q12.2  [Link to chromosome band 13q12]
Location_base_pair Starts at 27545913 and ends at 27620583 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LNX2 (13q12.2) / BNIP1 (5q35.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LNX2   20421
Cards
Entrez_Gene (NCBI)LNX2  222484  ligand of numb-protein X 2
AliasesPDZRN1
GeneCards (Weizmann)LNX2
Ensembl hg19 (Hinxton)ENSG00000139517 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000139517 [Gene_View]  chr13:27545913-27620583 [Contig_View]  LNX2 [Vega]
ICGC DataPortalENSG00000139517
TCGA cBioPortalLNX2
AceView (NCBI)LNX2
Genatlas (Paris)LNX2
WikiGenes222484
SOURCE (Princeton)LNX2
Genetics Home Reference (NIH)LNX2
Genomic and cartography
GoldenPath hg38 (UCSC)LNX2  -     chr13:27545913-27620583 -  13q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LNX2  -     13q12.2   [Description]    (hg19-Feb_2009)
EnsemblLNX2 - 13q12.2 [CytoView hg19]  LNX2 - 13q12.2 [CytoView hg38]
Mapping of homologs : NCBILNX2 [Mapview hg19]  LNX2 [Mapview hg38]
OMIM609733   
Gene and transcription
Genbank (Entrez)AK022995 AK095319 AK313394 BC036755 DB220129
RefSeq transcript (Entrez)NM_153371
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LNX2
Cluster EST : UnigeneHs.132359 [ NCBI ]
CGAP (NCI)Hs.132359
Alternative Splicing GalleryENSG00000139517
Gene ExpressionLNX2 [ NCBI-GEO ]   LNX2 [ EBI - ARRAY_EXPRESS ]   LNX2 [ SEEK ]   LNX2 [ MEM ]
Gene Expression Viewer (FireBrowse)LNX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)222484
GTEX Portal (Tissue expression)LNX2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N448   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N448  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N448
Splice isoforms : SwissVarQ8N448
PhosPhoSitePlusQ8N448
Domaine pattern : Prosite (Expaxy)PDZ (PS50106)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)PDZ    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam00595   
Domain families : Smart (EMBL)PDZ (SM00228)  RING (SM00184)  
Conserved Domain (NCBI)LNX2
DMDM Disease mutations222484
Blocks (Seattle)LNX2
PDB (SRS)2VWR    5DIN    5E11    5E1Y    5E21    5E22   
PDB (PDBSum)2VWR    5DIN    5E11    5E1Y    5E21    5E22   
PDB (IMB)2VWR    5DIN    5E11    5E1Y    5E21    5E22   
PDB (RSDB)2VWR    5DIN    5E11    5E1Y    5E21    5E22   
Structural Biology KnowledgeBase2VWR    5DIN    5E11    5E1Y    5E21    5E22   
SCOP (Structural Classification of Proteins)2VWR    5DIN    5E11    5E1Y    5E21    5E22   
CATH (Classification of proteins structures)2VWR    5DIN    5E11    5E1Y    5E21    5E22   
SuperfamilyQ8N448
Human Protein AtlasENSG00000139517
Peptide AtlasQ8N448
HPRD10042
IPIIPI00171047   
Protein Interaction databases
DIP (DOE-UCLA)Q8N448
IntAct (EBI)Q8N448
FunCoupENSG00000139517
BioGRIDLNX2
STRING (EMBL)LNX2
ZODIACLNX2
Ontologies - Pathways
QuickGOQ8N448
Ontology : AmiGOprotein binding  zinc ion binding  PDZ domain binding  protein homooligomerization  
Ontology : EGO-EBIprotein binding  zinc ion binding  PDZ domain binding  protein homooligomerization  
NDEx NetworkLNX2
Atlas of Cancer Signalling NetworkLNX2
Wikipedia pathwaysLNX2
Orthology - Evolution
OrthoDB222484
GeneTree (enSembl)ENSG00000139517
Phylogenetic Trees/Animal Genes : TreeFamLNX2
HOVERGENQ8N448
HOGENOMQ8N448
Homologs : HomoloGeneLNX2
Homology/Alignments : Family Browser (UCSC)LNX2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLNX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LNX2
dbVarLNX2
ClinVarLNX2
1000_GenomesLNX2 
Exome Variant ServerLNX2
ExAC (Exome Aggregation Consortium)LNX2 (select the gene name)
Genetic variants : HAPMAP222484
Genomic Variants (DGV)LNX2 [DGVbeta]
DECIPHERLNX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLNX2 
Mutations
ICGC Data PortalLNX2 
TCGA Data PortalLNX2 
Broad Tumor PortalLNX2
OASIS PortalLNX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLNX2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLNX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LNX2
DgiDB (Drug Gene Interaction Database)LNX2
DoCM (Curated mutations)LNX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LNX2 (select a term)
intoGenLNX2
Cancer3DLNX2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609733   
Orphanet
MedgenLNX2
Genetic Testing Registry LNX2
NextProtQ8N448 [Medical]
TSGene222484
GENETestsLNX2
Target ValidationLNX2
Huge Navigator LNX2 [HugePedia]
snp3D : Map Gene to Disease222484
BioCentury BCIQLNX2
ClinGenLNX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD222484
Chemical/Pharm GKB GenePA134899015
Clinical trialLNX2
Miscellaneous
canSAR (ICR)LNX2 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLNX2
EVEXLNX2
GoPubMedLNX2
iHOPLNX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:40:52 CEST 2017

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