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LONP1 (lon peptidase 1, mitochondrial)

Identity

Alias_namesPRSS15
protease
Alias_symbol (synonym)LonHS
hLON
PIM1
Other aliasCODASS
LON
LONP
HGNC (Hugo) LONP1
LocusID (NCBI) 9361
Atlas_Id 53020
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 5691845 and ends at 5720176 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BCL6 (3q27.3) / LONP1 (19p13.3)LONP1 (19p13.3) / AZIN1 (8q22.3)LONP1 (19p13.3) / BCL6 (3q27.3)
LONP1 (19p13.3) / DDX27 (20q13.13)LONP1 (19p13.3) / MAN1A2 (1p12)LONP1 (19p13.3) / MAP2K7 (19p13.2)
LONP1 (19p13.3) / ZNF780B (19q13.2)MAN1A2 (1p12) / LONP1 (19p13.3)SAFB2 (19p13.3) / LONP1 (19p13.3)
LONP1 19p13.3 / DDX27 20q13.13LONP1 19p13.3 / MAP2K7 19p13.2LONP1 19p13.3 / ZNF780B 19q13.2
SAFB2 19p13.3 / LONP1 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LONP1   9479
Cards
Entrez_Gene (NCBI)LONP1  9361  lon peptidase 1, mitochondrial
AliasesCODASS; LON; LONP; LonHS; 
PIM1; PRSS15; hLON
GeneCards (Weizmann)LONP1
Ensembl hg19 (Hinxton)ENSG00000196365 [Gene_View]  chr19:5691845-5720176 [Contig_View]  LONP1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000196365 [Gene_View]  chr19:5691845-5720176 [Contig_View]  LONP1 [Vega]
ICGC DataPortalENSG00000196365
TCGA cBioPortalLONP1
AceView (NCBI)LONP1
Genatlas (Paris)LONP1
WikiGenes9361
SOURCE (Princeton)LONP1
Genetics Home Reference (NIH)LONP1
Genomic and cartography
GoldenPath hg19 (UCSC)LONP1  -     chr19:5691845-5720176 -  19p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LONP1  -     19p13.3   [Description]    (hg38-Dec_2013)
EnsemblLONP1 - 19p13.3 [CytoView hg19]  LONP1 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBILONP1 [Mapview hg19]  LONP1 [Mapview hg38]
OMIM600373   605490   
Gene and transcription
Genbank (Entrez)AK056366 AK096433 AK096626 AK127867 AK298531
RefSeq transcript (Entrez)NM_001276479 NM_001276480 NM_004793
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_033142 NT_011295 NW_004929412
Consensus coding sequences : CCDS (NCBI)LONP1
Cluster EST : UnigeneHs.350265 [ NCBI ]
CGAP (NCI)Hs.350265
Alternative Splicing GalleryENSG00000196365
Gene ExpressionLONP1 [ NCBI-GEO ]   LONP1 [ EBI - ARRAY_EXPRESS ]   LONP1 [ SEEK ]   LONP1 [ MEM ]
Gene Expression Viewer (FireBrowse)LONP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9361
GTEX Portal (Tissue expression)LONP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36776   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36776  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36776
Splice isoforms : SwissVarP36776
PhosPhoSitePlusP36776
Domaine pattern : Prosite (Expaxy)LON_N (PS51787)    LON_PROTEOLYTIC (PS51786)    LON_SER (PS01046)   
Domains : Interpro (EBI)AAA+_ATPase    ATPase_AAA_core    Lon_bac/euk-typ    Lon_Prtase    LON_substr-bd_dom    Lonm_euk    P-loop_NTPase    Pept_S16_C    Peptidase_S16_AS    PUA-like_domain    Ribosomal_S5_D2-typ_fold    Ribosomal_S5_D2-typ_fold_subgr   
Domain families : Pfam (Sanger)AAA (PF00004)    Lon_C (PF05362)    LON_substr_bdg (PF02190)   
Domain families : Pfam (NCBI)pfam00004    pfam05362    pfam02190   
Domain families : Smart (EMBL)AAA (SM00382)  LON (SM00464)  
Conserved Domain (NCBI)LONP1
DMDM Disease mutations9361
Blocks (Seattle)LONP1
PDB (SRS)2X36   
PDB (PDBSum)2X36   
PDB (IMB)2X36   
PDB (RSDB)2X36   
Structural Biology KnowledgeBase2X36   
SCOP (Structural Classification of Proteins)2X36   
CATH (Classification of proteins structures)2X36   
SuperfamilyP36776
Human Protein AtlasENSG00000196365
Peptide AtlasP36776
HPRD05689
IPIIPI00005158   IPI00334291   IPI00642982   
Protein Interaction databases
DIP (DOE-UCLA)P36776
IntAct (EBI)P36776
FunCoupENSG00000196365
BioGRIDLONP1
STRING (EMBL)LONP1
ZODIACLONP1
Ontologies - Pathways
QuickGOP36776
Ontology : AmiGOmitochondrial genome maintenance  response to hypoxia  single-stranded DNA binding  single-stranded RNA binding  ATP-dependent peptidase activity  serine-type endopeptidase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  mitochondrion  mitochondrial matrix  misfolded or incompletely synthesized protein catabolic process  mitochondrion organization  aging  response to hormone  response to aluminum ion  membrane  mitochondrial DNA metabolic process  cellular response to oxidative stress  cellular response to oxidative stress  mitochondrial nucleoid  ADP binding  sequence-specific DNA binding  chaperone-mediated protein complex assembly  protein homooligomerization  proteolysis involved in cellular protein catabolic process  G-quadruplex DNA binding  DNA polymerase binding  mitochondrial light strand promoter anti-sense binding  mitochondrial heavy strand promoter anti-sense binding  mitochondrial light strand promoter sense binding  mitochondrial heavy strand promoter sense binding  oxidation-dependent protein catabolic process  
Ontology : EGO-EBImitochondrial genome maintenance  response to hypoxia  single-stranded DNA binding  single-stranded RNA binding  ATP-dependent peptidase activity  serine-type endopeptidase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  mitochondrion  mitochondrial matrix  misfolded or incompletely synthesized protein catabolic process  mitochondrion organization  aging  response to hormone  response to aluminum ion  membrane  mitochondrial DNA metabolic process  cellular response to oxidative stress  cellular response to oxidative stress  mitochondrial nucleoid  ADP binding  sequence-specific DNA binding  chaperone-mediated protein complex assembly  protein homooligomerization  proteolysis involved in cellular protein catabolic process  G-quadruplex DNA binding  DNA polymerase binding  mitochondrial light strand promoter anti-sense binding  mitochondrial heavy strand promoter anti-sense binding  mitochondrial light strand promoter sense binding  mitochondrial heavy strand promoter sense binding  oxidation-dependent protein catabolic process  
NDEx NetworkLONP1
Atlas of Cancer Signalling NetworkLONP1
Wikipedia pathwaysLONP1
Orthology - Evolution
OrthoDB9361
GeneTree (enSembl)ENSG00000196365
Phylogenetic Trees/Animal Genes : TreeFamLONP1
HOVERGENP36776
HOGENOMP36776
Homologs : HomoloGeneLONP1
Homology/Alignments : Family Browser (UCSC)LONP1
Gene fusions - Rearrangements
Fusion : MitelmanLONP1/DDX27 [19p13.3/20q13.13]  
Fusion : MitelmanLONP1/MAP2K7 [19p13.3/19p13.2]  [t(19;19)(p13;p13)]  
Fusion : MitelmanLONP1/ZNF780B [19p13.3/19q13.2]  [t(19;19)(p13;q13)]  
Fusion : MitelmanSAFB2/LONP1 [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion: TCGALONP1 19p13.3 DDX27 20q13.13 LUAD
Fusion: TCGALONP1 19p13.3 MAP2K7 19p13.2 BRCA
Fusion: TCGALONP1 19p13.3 ZNF780B 19q13.2 BRCA
Fusion: TCGASAFB2 19p13.3 LONP1 19p13.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLONP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LONP1
dbVarLONP1
ClinVarLONP1
1000_GenomesLONP1 
Exome Variant ServerLONP1
ExAC (Exome Aggregation Consortium)LONP1 (select the gene name)
Genetic variants : HAPMAP9361
Genomic Variants (DGV)LONP1 [DGVbeta]
DECIPHER (Syndromes)19:5691845-5720176  ENSG00000196365
CONAN: Copy Number AnalysisLONP1 
Mutations
ICGC Data PortalLONP1 
TCGA Data PortalLONP1 
Broad Tumor PortalLONP1
OASIS PortalLONP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLONP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLONP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch LONP1
DgiDB (Drug Gene Interaction Database)LONP1
DoCM (Curated mutations)LONP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LONP1 (select a term)
intoGenLONP1
Cancer3DLONP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600373    605490   
Orphanet1647   
MedgenLONP1
Genetic Testing Registry LONP1
NextProtP36776 [Medical]
TSGene9361
GENETestsLONP1
Huge Navigator LONP1 [HugePedia]
snp3D : Map Gene to Disease9361
BioCentury BCIQLONP1
ClinGenLONP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9361
Chemical/Pharm GKB GenePA162394145
Clinical trialLONP1
Miscellaneous
canSAR (ICR)LONP1 (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLONP1
EVEXLONP1
GoPubMedLONP1
iHOPLONP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:13:40 CET 2017

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