LONP2 (lon peptidase 2, peroxisomal)

2018-11-01  

Identity

HGNC
LOCATION
16q12.1
LOCUSID
ALIAS
LONP,LONPL,PLON,PSLON
FUSION GENES

Other Information

Locus ID:

NCBI: 83752
MIM: 617774
HGNC: 20598
Ensembl: ENSG00000102910

Variants:

dbSNP: 83752
ClinVar: 83752
TCGA: ENSG00000102910
COSMIC: LONP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102910ENST00000285737Q86WA8
ENSG00000102910ENST00000416006E7EN44
ENSG00000102910ENST00000535754Q86WA8
ENSG00000102910ENST00000565867H3BPF7
ENSG00000102910ENST00000566755H3BUW8
ENSG00000102910ENST00000570174H3BQ67

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
158700802005Cleavage site selection within a folded substrate by the ATP-dependent lon protease.36
220020622011Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix.18
295021282018Lon Peptidase 2, Peroxisomal (LONP2) Contributes to Cervical Carcinogenesis via Oxidative Stress.3

Citation

Dessen P

LONP2 (lon peptidase 2, peroxisomal)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57664/lonp2