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LONP2 (lon peptidase 2, peroxisomal)

Identity

Alias_symbol (synonym)MGC4840
LONP
LONPL
Other aliasPLON
PSLON
HGNC (Hugo) LONP2
LocusID (NCBI) 83752
Atlas_Id 68551
Location 16q12.1  [Link to chromosome band 16q12]
Location_base_pair Starts at 48244167 and ends at 48353979 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LONP2 (16q12.1) / HIRA (22q11.21)LONP2 (16q12.1) / SIAH1 (16q12.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LONP2   20598
Cards
Entrez_Gene (NCBI)LONP2  83752  lon peptidase 2, peroxisomal
AliasesLONP; LONPL; PLON; PSLON
GeneCards (Weizmann)LONP2
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr16:48244167-48353979 [Contig_View]  LONP2 [Vega]
TCGA cBioPortalLONP2
AceView (NCBI)LONP2
Genatlas (Paris)LONP2
WikiGenes83752
SOURCE (Princeton)LONP2
Genetics Home Reference (NIH)LONP2
Genomic and cartography
GoldenPath hg38 (UCSC)LONP2  -     chr16:48244167-48353979 +  16q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LONP2  -     16q12.1   [Description]    (hg19-Feb_2009)
EnsemblLONP2 - 16q12.1 [CytoView hg19]  LONP2 - 16q12.1 [CytoView hg38]
Mapping of homologs : NCBILONP2 [Mapview hg19]  LONP2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AJ548761 AK027544 AK027666 AK056051 AK074775
RefSeq transcript (Entrez)NM_001300948 NM_001348078 NM_031490
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LONP2
Cluster EST : UnigeneHs.744137 [ NCBI ]
CGAP (NCI)Hs.744137
Gene ExpressionLONP2 [ NCBI-GEO ]   LONP2 [ EBI - ARRAY_EXPRESS ]   LONP2 [ SEEK ]   LONP2 [ MEM ]
Gene Expression Viewer (FireBrowse)LONP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83752
GTEX Portal (Tissue expression)LONP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86WA8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86WA8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86WA8
Splice isoforms : SwissVarQ86WA8
PhosPhoSitePlusQ86WA8
Domaine pattern : Prosite (Expaxy)LON_N (PS51787)    LON_PROTEOLYTIC (PS51786)    LON_SER (PS01046)   
Domains : Interpro (EBI)AAA+_ATPase    ATPase_AAA_core    Lon_bac/euk-typ    Lon_Prtase    LON_substr-bd_dom    Lonp2_euk    P-loop_NTPase    Pept_S16_C    Peptidase_S16_AS    PUA-like_domain    Ribosomal_S5_D2-typ_fold    Ribosomal_S5_D2-typ_fold_subgr   
Domain families : Pfam (Sanger)AAA (PF00004)    Lon_C (PF05362)    LON_substr_bdg (PF02190)   
Domain families : Pfam (NCBI)pfam00004    pfam05362    pfam02190   
Domain families : Smart (EMBL)AAA (SM00382)  LON (SM00464)  
Conserved Domain (NCBI)LONP2
DMDM Disease mutations83752
Blocks (Seattle)LONP2
SuperfamilyQ86WA8
Peptide AtlasQ86WA8
HPRD07491
IPIIPI00410584   IPI00942554   IPI01013325   IPI00386184   IPI01013868   
Protein Interaction databases
DIP (DOE-UCLA)Q86WA8
IntAct (EBI)Q86WA8
BioGRIDLONP2
STRING (EMBL)LONP2
ZODIACLONP2
Ontologies - Pathways
QuickGOQ86WA8
Ontology : AmiGOprotease binding  ATP-dependent peptidase activity  serine-type endopeptidase activity  receptor binding  protein binding  ATP binding  nucleus  peroxisome  peroxisomal matrix  misfolded or incompletely synthesized protein catabolic process  protein targeting to peroxisome  peroxisome organization  peptidase activity  response to organic cyclic compound  membrane  protein processing  enzyme binding  regulation of fatty acid beta-oxidation  
Ontology : EGO-EBIprotease binding  ATP-dependent peptidase activity  serine-type endopeptidase activity  receptor binding  protein binding  ATP binding  nucleus  peroxisome  peroxisomal matrix  misfolded or incompletely synthesized protein catabolic process  protein targeting to peroxisome  peroxisome organization  peptidase activity  response to organic cyclic compound  membrane  protein processing  enzyme binding  regulation of fatty acid beta-oxidation  
NDEx NetworkLONP2
Atlas of Cancer Signalling NetworkLONP2
Wikipedia pathwaysLONP2
Orthology - Evolution
OrthoDB83752
Phylogenetic Trees/Animal Genes : TreeFamLONP2
HOVERGENQ86WA8
HOGENOMQ86WA8
Homologs : HomoloGeneLONP2
Homology/Alignments : Family Browser (UCSC)LONP2
Gene fusions - Rearrangements
Tumor Fusion PortalLONP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLONP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LONP2
dbVarLONP2
ClinVarLONP2
1000_GenomesLONP2 
Exome Variant ServerLONP2
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP83752
Genomic Variants (DGV)LONP2 [DGVbeta]
DECIPHERLONP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLONP2 
Mutations
ICGC Data PortalLONP2 
TCGA Data PortalLONP2 
Broad Tumor PortalLONP2
OASIS PortalLONP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLONP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLONP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LONP2
DgiDB (Drug Gene Interaction Database)LONP2
DoCM (Curated mutations)LONP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LONP2 (select a term)
intoGenLONP2
Cancer3DLONP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETLONP2
MedgenLONP2
Genetic Testing Registry LONP2
NextProtQ86WA8 [Medical]
TSGene83752
GENETestsLONP2
Target ValidationLONP2
Huge Navigator LONP2 [HugePedia]
snp3D : Map Gene to Disease83752
BioCentury BCIQLONP2
ClinGenLONP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD83752
Chemical/Pharm GKB GenePA162394186
Clinical trialLONP2
Miscellaneous
canSAR (ICR)LONP2 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLONP2
EVEXLONP2
GoPubMedLONP2
iHOPLONP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:33:38 CET 2017

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