LOXL1 (lysyl oxidase like 1)

2007-04-01  

Identity

HGNC
LOCATION
15q24.1
LOCUSID
ALIAS
LOL,LOXL
FUSION GENES

Other Information

Locus ID:

NCBI: 4016
MIM: 153456
HGNC: 6665
Ensembl: ENSG00000129038

Variants:

dbSNP: 4016
ClinVar: 4016
TCGA: ENSG00000129038
COSMIC: LOXL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129038ENST00000261921Q08397
ENSG00000129038ENST00000566011H3BUV8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Assembly of collagen fibrils and other multimeric structuresREACTOMER-HSA-2022090
Crosslinking of collagen fibrilsREACTOMER-HSA-2243919
Elastic fibre formationREACTOMER-HSA-1566948

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382175412024Mechanism of lysine oxidase-like 1 promoting synovial inflammation mediating rheumatoid arthritis development.0
382676622024LOXL1 promotes tumor cell malignancy and restricts CD8 + T cell infiltration in colorectal cancer.1
384668822024Crosstalk of lysyl oxidase-like 1 and lysyl oxidase prolongs their half-lives and regulates liver fibrosis through Notch signal.0
382175412024Mechanism of lysine oxidase-like 1 promoting synovial inflammation mediating rheumatoid arthritis development.0
382676622024LOXL1 promotes tumor cell malignancy and restricts CD8 + T cell infiltration in colorectal cancer.1
384668822024Crosstalk of lysyl oxidase-like 1 and lysyl oxidase prolongs their half-lives and regulates liver fibrosis through Notch signal.0
365649632023Single nucleotide polymorphisms in LOXL1 as biomarkers for progression of exfoliation glaucoma in Sweden.3
365649632023Single nucleotide polymorphisms in LOXL1 as biomarkers for progression of exfoliation glaucoma in Sweden.3
354402442022The rs2165241 polymorphism of the Loxl1 gene in postmenopausal women with pelvic organ prolapse.0
356479732022Prevalence of risk alleles in the lysyl oxidase-like 1 gene in pseudoexfoliation glaucoma patients in India.1
354402442022The rs2165241 polymorphism of the Loxl1 gene in postmenopausal women with pelvic organ prolapse.0
356479732022Prevalence of risk alleles in the lysyl oxidase-like 1 gene in pseudoexfoliation glaucoma patients in India.1
337924952021Correlation of the intronic LOXL1 polymorphism rs11638944 with pseudoexfoliation syndrome and glaucoma in a Greek population.0
339096952021LOXL1 gene polymorphisms are associated with exfoliation syndrome/exfoliation glaucoma risk: An updated meta-analysis.4
340122282021LOXL1 gene polymorphism candidates for exfoliation glaucoma are also associated with a risk for primary open-angle glaucoma in a Caucasian population from central Russia.17

Citation

Dessen P

LOXL1 (lysyl oxidase like 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47157/loxl1