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LPA (lipoprotein(a))

Identity

Alias_namesLP
lipoprotein
Alias_symbol (synonym)Lp(a)
Other aliasAK38
APOA
HGNC (Hugo) LPA
LocusID (NCBI) 4018
Atlas_Id 50112
Location 6q25.3  [Link to chromosome band 6q25]
Location_base_pair Starts at 160531483 and ends at 160666375 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LPA   6667
Cards
Entrez_Gene (NCBI)LPA  4018  lipoprotein(a)
AliasesAK38; APOA; LP
GeneCards (Weizmann)LPA
Ensembl hg19 (Hinxton)ENSG00000198670 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198670 [Gene_View]  ENSG00000198670 [Sequence]  chr6:160531483-160666375 [Contig_View]  LPA [Vega]
ICGC DataPortalENSG00000198670
TCGA cBioPortalLPA
AceView (NCBI)LPA
Genatlas (Paris)LPA
WikiGenes4018
SOURCE (Princeton)LPA
Genetics Home Reference (NIH)LPA
Genomic and cartography
GoldenPath hg38 (UCSC)LPA  -     chr6:160531483-160666375 -  6q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LPA  -     6q25.3   [Description]    (hg19-Feb_2009)
EnsemblLPA - 6q25.3 [CytoView hg19]  LPA - 6q25.3 [CytoView hg38]
Mapping of homologs : NCBILPA [Mapview hg19]  LPA [Mapview hg38]
OMIM152200   
Gene and transcription
Genbank (Entrez)AY039748 X06290
RefSeq transcript (Entrez)NM_005577
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LPA
Cluster EST : UnigeneHs.520120 [ NCBI ]
CGAP (NCI)Hs.520120
Alternative Splicing GalleryENSG00000198670
Gene ExpressionLPA [ NCBI-GEO ]   LPA [ EBI - ARRAY_EXPRESS ]   LPA [ SEEK ]   LPA [ MEM ]
Gene Expression Viewer (FireBrowse)LPA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4018
GTEX Portal (Tissue expression)LPA
Human Protein AtlasENSG00000198670-LPA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08519   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08519  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08519
Splice isoforms : SwissVarP08519
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
PhosPhoSitePlusP08519
Domaine pattern : Prosite (Expaxy)KRINGLE_1 (PS00021)    KRINGLE_2 (PS50070)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Kringle    Kringle-like    Kringle_CS    Kringle_sf    Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Kringle (PF00051)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00051    pfam00089   
Domain families : Smart (EMBL)KR (SM00130)  Tryp_SPc (SM00020)  
Conserved Domain (NCBI)LPA
DMDM Disease mutations4018
Blocks (Seattle)LPA
PDB (SRS)1I71    1JFN    1KIV    2FEB    3KIV    4BV5    4BV7    4BVC    4BVD    4BVV    4BVW    4KIV   
PDB (PDBSum)1I71    1JFN    1KIV    2FEB    3KIV    4BV5    4BV7    4BVC    4BVD    4BVV    4BVW    4KIV   
PDB (IMB)1I71    1JFN    1KIV    2FEB    3KIV    4BV5    4BV7    4BVC    4BVD    4BVV    4BVW    4KIV   
PDB (RSDB)1I71    1JFN    1KIV    2FEB    3KIV    4BV5    4BV7    4BVC    4BVD    4BVV    4BVW    4KIV   
Structural Biology KnowledgeBase1I71    1JFN    1KIV    2FEB    3KIV    4BV5    4BV7    4BVC    4BVD    4BVV    4BVW    4KIV   
SCOP (Structural Classification of Proteins)1I71    1JFN    1KIV    2FEB    3KIV    4BV5    4BV7    4BVC    4BVD    4BVV    4BVW    4KIV   
CATH (Classification of proteins structures)1I71    1JFN    1KIV    2FEB    3KIV    4BV5    4BV7    4BVC    4BVD    4BVV    4BVW    4KIV   
SuperfamilyP08519
Human Protein Atlas [tissue]ENSG00000198670-LPA [tissue]
Peptide AtlasP08519
HPRD01063
IPIIPI00029168   IPI00164229   
Protein Interaction databases
DIP (DOE-UCLA)P08519
IntAct (EBI)P08519
FunCoupENSG00000198670
BioGRIDLPA
STRING (EMBL)LPA
ZODIACLPA
Ontologies - Pathways
QuickGOP08519
Ontology : AmiGOfibronectin binding  serine-type endopeptidase activity  serine-type endopeptidase activity  endopeptidase inhibitor activity  protein binding  extracellular region  extracellular region  proteolysis  lipid metabolic process  lipid transport  blood circulation  heparin binding  negative regulation of endopeptidase activity  apolipoprotein binding  plasma lipoprotein particle  low-density lipoprotein particle remodeling  
Ontology : EGO-EBIfibronectin binding  serine-type endopeptidase activity  serine-type endopeptidase activity  endopeptidase inhibitor activity  protein binding  extracellular region  extracellular region  proteolysis  lipid metabolic process  lipid transport  blood circulation  heparin binding  negative regulation of endopeptidase activity  apolipoprotein binding  plasma lipoprotein particle  low-density lipoprotein particle remodeling  
NDEx NetworkLPA
Atlas of Cancer Signalling NetworkLPA
Wikipedia pathwaysLPA
Orthology - Evolution
OrthoDB4018
GeneTree (enSembl)ENSG00000198670
Phylogenetic Trees/Animal Genes : TreeFamLPA
HOVERGENP08519
HOGENOMP08519
Homologs : HomoloGeneLPA
Homology/Alignments : Family Browser (UCSC)LPA
Gene fusions - Rearrangements
Fusion : QuiverLPA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLPA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LPA
dbVarLPA
ClinVarLPA
1000_GenomesLPA 
Exome Variant ServerLPA
ExAC (Exome Aggregation Consortium)ENSG00000198670
GNOMAD BrowserENSG00000198670
Varsome BrowserLPA
Genetic variants : HAPMAP4018
Genomic Variants (DGV)LPA [DGVbeta]
DECIPHERLPA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLPA 
Mutations
ICGC Data PortalLPA 
TCGA Data PortalLPA 
Broad Tumor PortalLPA
OASIS PortalLPA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLPA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLPA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LPA
DgiDB (Drug Gene Interaction Database)LPA
DoCM (Curated mutations)LPA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LPA (select a term)
intoGenLPA
Cancer3DLPA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM152200   
Orphanet
DisGeNETLPA
MedgenLPA
Genetic Testing Registry LPA
NextProtP08519 [Medical]
TSGene4018
GENETestsLPA
Target ValidationLPA
Huge Navigator LPA [HugePedia]
snp3D : Map Gene to Disease4018
BioCentury BCIQLPA
ClinGenLPA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4018
Chemical/Pharm GKB GenePA30432
Clinical trialLPA
Miscellaneous
canSAR (ICR)LPA (select the gene name)
Probes
Litterature
PubMed343 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLPA
EVEXLPA
GoPubMedLPA
iHOPLPA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:17:44 CET 2018

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