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LPA (lipoprotein, Lp(a))

Identity

Other namesAK38
APOA
LP
HGNC (Hugo) LPA
LocusID (NCBI) 4018
Location 6q25.3
Location_base_pair Starts at 160952515 and ends at 161087407 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LPA   6667
Entrez_Gene (NCBI)LPA  4018  lipoprotein, Lp(a)
Cards
GeneCards (Weizmann)LPA
Ensembl (Hinxton)ENSG00000198670 [Gene_View]  chr6:160952515-161087407 [Contig_View]  LPA [Vega]
AceView (NCBI)LPA
Genatlas (Paris)LPA
SOURCE (Stanford)NM_005577
Genomic and cartography
GoldenPath (UCSC)LPA  -  6q25.3   chr6:160952515-161087407 -  6q25.3   [Description]    (hg19-Feb_2009)
EnsemblLPA - 6q25.3 [CytoView]
Mapping of homologs : NCBILPA [Mapview]
OMIM152200   
Gene and transcription
Genbank (Entrez)AY039748 X06290
RefSeq transcript (SRS)NM_005577
RefSeq transcript (Entrez)NM_005577
RefSeq genomic (SRS)AC_000138 NC_000006 NC_018917 NG_016147 NT_025741 NW_001838991 NW_001838992 NW_004078028
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NG_016147 NT_025741 NW_001838991 NW_001838992 NW_004078028
Consensus coding sequences : CCDS (NCBI)LPA
Cluster EST : UnigeneHs.520120 [ SRS ] Hs.520120 [ NCBI ]
CGAP (NCI)Hs.520120
Alternative Splicing : Fast-db (Paris)GSHG0043507
Alternative Splicing GalleryENSG00000198670
Gene ExpressionLPA [ NCBI-GEO ]   LPA [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08519 (SRS) P08519 (Uniprot)
NextProtP08519
With graphics : InterProP08519
Splice isoforms : SwissVarP08519(Swissvar)
Domaine pattern : Prosite (SRS)KRINGLE_1 (PS00021)    KRINGLE_2 (PS50070)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domaine pattern : Prosite (Expaxy)KRINGLE_1 (PS00021)    KRINGLE_2 (PS50070)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (SRS)Kringle    Kringle-like    Kringle_CS    Pept_cys/ser_Trypsin-like    Peptidase_S1/S6_AS    Peptidase_S1_S6    Peptidase_S1A   
Domains : Interpro (EBI)Kringle    Kringle-like    Kringle_CS    Pept_cys/ser_Trypsin-like    Peptidase_S1/S6_AS    Peptidase_S1_S6    Peptidase_S1A   
Related proteins : CluSTrP08519
Domain families : Pfam (SRS)Kringle (PF00051)    Trypsin (PF00089)   
Domain families : Pfam (Sanger)Kringle (PF00051)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00051    pfam00089   
Domain families : Smart (EMBL)KR (SM00130)  Tryp_SPc (SM00020)  
DMDM4018
Blocks (Seattle)P08519
PDB (SRS)1I71    1JFN    1KIV    2FEB    3KIV    4KIV   
PDB (PDBSum)1I71    1JFN    1KIV    2FEB    3KIV    4KIV   
PDB (IMB)1I71    1JFN    1KIV    2FEB    3KIV    4KIV   
PDB (RSDB)1I71    1JFN    1KIV    2FEB    3KIV    4KIV   
Human Protein AtlasENSG00000198670
HPRD01063
IPIIPI00029168   IPI00164229   
Protein Interaction databases
DIP (DOE-UCLA)P08519
IntAct (EBI)P08519
FunCoupENSG00000198670
REACTOMELPA
Protein Interaction Database4018
BioGRIDLPA
InParanoidP08519
Interologous Interaction database P08519
IntegromeDBLPA
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)LPA
SNP (GeneSNP Utah)LPA
SNP : HGBaseLPA
Genetic variants : HAPMAPLPA
Somatic Mutations in Cancer : COSMICLPA 
CONAN: Copy Number AnalysisLPA 
Mutations and Diseases : HGMDLPA
OMIM152200   
GENETests152200   
Disease Genetic AssociationLPA
Huge Navigator LPA [HugePedia]  LPA [HugeCancerGEM]
Genomic VariantsLPA  LPA [DGVbeta]
snp3D : Map Gene to Disease4018
General knowledge
Homologs : HomoloGeneLPA
Homology/Alignments : Family Browser (UCSC)LPA
Phylogenetic Trees/Animal Genes : TreeFamLPA
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.- [ Enzyme-SRS ]   3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
Chemical/Protein Interactions : CTD4018
Chemical/Pharm GKB GenePA30432
Clinical trialLPA
Cancer Resource (Charite)ENSG00000198670
Ontology : AmiGOfibronectin binding  serine-type endopeptidase activity  endopeptidase inhibitor activity  extracellular region  extracellular region  proteolysis  lipid metabolic process  lipid transport  receptor-mediated endocytosis  blood circulation  heparin binding  negative regulation of endopeptidase activity  apolipoprotein binding  plasma lipoprotein particle  lipoprotein metabolic process  small molecule metabolic process  
Ontology : EGO-EBIfibronectin binding  serine-type endopeptidase activity  endopeptidase inhibitor activity  extracellular region  extracellular region  proteolysis  lipid metabolic process  lipid transport  receptor-mediated endocytosis  blood circulation  heparin binding  negative regulation of endopeptidase activity  apolipoprotein binding  plasma lipoprotein particle  lipoprotein metabolic process  small molecule metabolic process  
Other databases
Probes
Litterature
PubMed188 Pubmed reference(s) in Entrez
PubGeneLPA
iHOPLPA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:47:12 CEST 2013
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