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LPAR5 (lysophosphatidic acid receptor 5)

Identity

Alias_namesGPR93
GPR92
G protein-coupled receptor 92
Alias_symbol (synonym)KPG_010
LPA5
Other alias
HGNC (Hugo) LPAR5
LocusID (NCBI) 57121
Atlas_Id 54426
Location 12p13.31  [Link to chromosome band 12p13]
Location_base_pair Starts at 6618835 and ends at 6636131 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LPAR5 (12p13.31) / RPL3 (22q13.1)SCNN1A (12p13.31) / LPAR5 (12p13.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;22)(p13;q13) LPAR5/EP300


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  dup(12)(p13p13) SCNN1A/LPAR5


External links

Nomenclature
HGNC (Hugo)LPAR5   13307
Cards
Entrez_Gene (NCBI)LPAR5  57121  lysophosphatidic acid receptor 5
AliasesGPR92; GPR93; KPG_010; LPA5
GeneCards (Weizmann)LPAR5
Ensembl hg19 (Hinxton)ENSG00000184574 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184574 [Gene_View]  ENSG00000184574 [Sequence]  chr12:6618835-6636131 [Contig_View]  LPAR5 [Vega]
ICGC DataPortalENSG00000184574
TCGA cBioPortalLPAR5
AceView (NCBI)LPAR5
Genatlas (Paris)LPAR5
WikiGenes57121
SOURCE (Princeton)LPAR5
Genetics Home Reference (NIH)LPAR5
Genomic and cartography
GoldenPath hg38 (UCSC)LPAR5  -     chr12:6618835-6636131 -  12p13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LPAR5  -     12p13.31   [Description]    (hg19-Feb_2009)
EnsemblLPAR5 - 12p13.31 [CytoView hg19]  LPAR5 - 12p13.31 [CytoView hg38]
Mapping of homologs : NCBILPAR5 [Mapview hg19]  LPAR5 [Mapview hg38]
OMIM606926   
Gene and transcription
Genbank (Entrez)AB041943 AJ272207 AK313127 BC033571 BC072394
RefSeq transcript (Entrez)NM_001142961 NM_020400
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LPAR5
Cluster EST : UnigeneHs.155538 [ NCBI ]
CGAP (NCI)Hs.155538
Alternative Splicing GalleryENSG00000184574
Gene ExpressionLPAR5 [ NCBI-GEO ]   LPAR5 [ EBI - ARRAY_EXPRESS ]   LPAR5 [ SEEK ]   LPAR5 [ MEM ]
Gene Expression Viewer (FireBrowse)LPAR5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57121
GTEX Portal (Tissue expression)LPAR5
Human Protein AtlasENSG00000184574-LPAR5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H1C0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H1C0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H1C0
Splice isoforms : SwissVarQ9H1C0
PhosPhoSitePlusQ9H1C0
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)LPAR5
DMDM Disease mutations57121
Blocks (Seattle)LPAR5
SuperfamilyQ9H1C0
Human Protein Atlas [tissue]ENSG00000184574-LPAR5 [tissue]
Peptide AtlasQ9H1C0
HPRD09495
IPIIPI00942484   IPI00006962   
Protein Interaction databases
DIP (DOE-UCLA)Q9H1C0
IntAct (EBI)Q9H1C0
FunCoupENSG00000184574
BioGRIDLPAR5
STRING (EMBL)LPAR5
ZODIACLPAR5
Ontologies - Pathways
QuickGOQ9H1C0
Ontology : AmiGOmolecular_function  G protein-coupled receptor activity  cellular_component  plasma membrane  G protein-coupled receptor signaling pathway  biological_process  integral component of membrane  
Ontology : EGO-EBImolecular_function  G protein-coupled receptor activity  cellular_component  plasma membrane  G protein-coupled receptor signaling pathway  biological_process  integral component of membrane  
Pathways : KEGGRap1 signaling pathway    PI3K-Akt signaling pathway   
NDEx NetworkLPAR5
Atlas of Cancer Signalling NetworkLPAR5
Wikipedia pathwaysLPAR5
Orthology - Evolution
OrthoDB57121
GeneTree (enSembl)ENSG00000184574
Phylogenetic Trees/Animal Genes : TreeFamLPAR5
HOVERGENQ9H1C0
HOGENOMQ9H1C0
Homologs : HomoloGeneLPAR5
Homology/Alignments : Family Browser (UCSC)LPAR5
Gene fusions - Rearrangements
Fusion : MitelmanSCNN1A/LPAR5 [12p13.31/12p13.31]  [dup(12)(p13p13)]  
Fusion : QuiverLPAR5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLPAR5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LPAR5
dbVarLPAR5
ClinVarLPAR5
1000_GenomesLPAR5 
Exome Variant ServerLPAR5
ExAC (Exome Aggregation Consortium)ENSG00000184574
GNOMAD BrowserENSG00000184574
Varsome BrowserLPAR5
Genetic variants : HAPMAP57121
Genomic Variants (DGV)LPAR5 [DGVbeta]
DECIPHERLPAR5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLPAR5 
Mutations
ICGC Data PortalLPAR5 
TCGA Data PortalLPAR5 
Broad Tumor PortalLPAR5
OASIS PortalLPAR5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLPAR5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLPAR5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LPAR5
DgiDB (Drug Gene Interaction Database)LPAR5
DoCM (Curated mutations)LPAR5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LPAR5 (select a term)
intoGenLPAR5
Cancer3DLPAR5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606926   
Orphanet
DisGeNETLPAR5
MedgenLPAR5
Genetic Testing Registry LPAR5
NextProtQ9H1C0 [Medical]
TSGene57121
GENETestsLPAR5
Target ValidationLPAR5
Huge Navigator LPAR5 [HugePedia]
snp3D : Map Gene to Disease57121
BioCentury BCIQLPAR5
ClinGenLPAR5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57121
Chemical/Pharm GKB GenePA28935
Clinical trialLPAR5
Miscellaneous
canSAR (ICR)LPAR5 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLPAR5
EVEXLPAR5
GoPubMedLPAR5
iHOPLPAR5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:17:45 CET 2018

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