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LPCAT3 (lysophosphatidylcholine acyltransferase 3)

Identity

Alias_namesOACT5
MBOAT5
O-acyltransferase (membrane bound) domain containing 5
membrane bound O-acyltransferase domain containing 5
Alias_symbol (synonym)C3F
nessy
Other aliasLPCAT
LPLAT 5
LPSAT
HGNC (Hugo) LPCAT3
LocusID (NCBI) 10162
Atlas_Id 887
Location 12p13.31  [Link to chromosome band 12p13]
Location_base_pair Starts at 6976185 and ends at 7018538 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LPCAT3 (12p13.31) / GSG1L (16p12.1)LPCAT3 (12p13.31) / LRRC23 (12p13.31)LPCAT3 12p13.31 / LRRC23 12p13.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  LPCAT3/LRRC23 (12p13)


External links

Nomenclature
HGNC (Hugo)LPCAT3   30244
Cards
Entrez_Gene (NCBI)LPCAT3  10162  lysophosphatidylcholine acyltransferase 3
AliasesC3F; LPCAT; LPLAT; LPSAT; 
MBOAT5; OACT5; nessy
GeneCards (Weizmann)LPCAT3
Ensembl hg19 (Hinxton)ENSG00000111684 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111684 [Gene_View]  ENSG00000111684 [Sequence]  chr12:6976185-7018538 [Contig_View]  LPCAT3 [Vega]
ICGC DataPortalENSG00000111684
TCGA cBioPortalLPCAT3
AceView (NCBI)LPCAT3
Genatlas (Paris)LPCAT3
WikiGenes10162
SOURCE (Princeton)LPCAT3
Genetics Home Reference (NIH)LPCAT3
Genomic and cartography
GoldenPath hg38 (UCSC)LPCAT3  -     chr12:6976185-7018538 -  12p13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LPCAT3  -     12p13.31   [Description]    (hg19-Feb_2009)
EnsemblLPCAT3 - 12p13.31 [CytoView hg19]  LPCAT3 - 12p13.31 [CytoView hg38]
Mapping of homologs : NCBILPCAT3 [Mapview hg19]  LPCAT3 [Mapview hg38]
OMIM611950   
Gene and transcription
Genbank (Entrez)AK058063 AK096775 AK296145 AK296164 AK296171
RefSeq transcript (Entrez)NM_005768
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LPCAT3
Cluster EST : UnigeneHs.655248 [ NCBI ]
CGAP (NCI)Hs.655248
Alternative Splicing GalleryENSG00000111684
Gene ExpressionLPCAT3 [ NCBI-GEO ]   LPCAT3 [ EBI - ARRAY_EXPRESS ]   LPCAT3 [ SEEK ]   LPCAT3 [ MEM ]
Gene Expression Viewer (FireBrowse)LPCAT3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10162
GTEX Portal (Tissue expression)LPCAT3
Human Protein AtlasENSG00000111684-LPCAT3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6P1A2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6P1A2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6P1A2
Splice isoforms : SwissVarQ6P1A2
Catalytic activity : Enzyme2.3.1.- [ Enzyme-Expasy ]   2.3.1.-2.3.1.- [ IntEnz-EBI ]   2.3.1.- [ BRENDA ]   2.3.1.- [ KEGG ]   
PhosPhoSitePlusQ6P1A2
Domains : Interpro (EBI)MBOAT_fam   
Domain families : Pfam (Sanger)MBOAT (PF03062)   
Domain families : Pfam (NCBI)pfam03062   
Conserved Domain (NCBI)LPCAT3
DMDM Disease mutations10162
Blocks (Seattle)LPCAT3
SuperfamilyQ6P1A2
Human Protein Atlas [tissue]ENSG00000111684-LPCAT3 [tissue]
Peptide AtlasQ6P1A2
HPRD12816
IPIIPI00306419   IPI01010198   IPI01009377   IPI01009749   IPI00921984   IPI01014614   
Protein Interaction databases
DIP (DOE-UCLA)Q6P1A2
IntAct (EBI)Q6P1A2
FunCoupENSG00000111684
BioGRIDLPCAT3
STRING (EMBL)LPCAT3
ZODIACLPCAT3
Ontologies - Pathways
QuickGOQ6P1A2
Ontology : AmiGO1-acylglycerol-3-phosphate O-acyltransferase activity  endoplasmic reticulum membrane  phospholipid biosynthetic process  membrane  integral component of membrane  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  2-acylglycerol-3-phosphate O-acyltransferase activity  1-acylglycerophosphocholine O-acyltransferase activity  regulation of plasma lipoprotein particle levels  
Ontology : EGO-EBI1-acylglycerol-3-phosphate O-acyltransferase activity  endoplasmic reticulum membrane  phospholipid biosynthetic process  membrane  integral component of membrane  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  2-acylglycerol-3-phosphate O-acyltransferase activity  1-acylglycerophosphocholine O-acyltransferase activity  regulation of plasma lipoprotein particle levels  
Pathways : KEGGGlycerophospholipid metabolism   
NDEx NetworkLPCAT3
Atlas of Cancer Signalling NetworkLPCAT3
Wikipedia pathwaysLPCAT3
Orthology - Evolution
OrthoDB10162
GeneTree (enSembl)ENSG00000111684
Phylogenetic Trees/Animal Genes : TreeFamLPCAT3
HOVERGENQ6P1A2
HOGENOMQ6P1A2
Homologs : HomoloGeneLPCAT3
Homology/Alignments : Family Browser (UCSC)LPCAT3
Gene fusions - Rearrangements
Fusion : MitelmanLPCAT3/LRRC23 [12p13.31/12p13.31]  
Fusion PortalLPCAT3 12p13.31 LRRC23 12p13.31 LUAD
Fusion : QuiverLPCAT3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLPCAT3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LPCAT3
dbVarLPCAT3
ClinVarLPCAT3
1000_GenomesLPCAT3 
Exome Variant ServerLPCAT3
ExAC (Exome Aggregation Consortium)ENSG00000111684
GNOMAD BrowserENSG00000111684
Varsome BrowserLPCAT3
Genetic variants : HAPMAP10162
Genomic Variants (DGV)LPCAT3 [DGVbeta]
DECIPHERLPCAT3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLPCAT3 
Mutations
ICGC Data PortalLPCAT3 
TCGA Data PortalLPCAT3 
Broad Tumor PortalLPCAT3
OASIS PortalLPCAT3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLPCAT3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLPCAT3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LPCAT3
DgiDB (Drug Gene Interaction Database)LPCAT3
DoCM (Curated mutations)LPCAT3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LPCAT3 (select a term)
intoGenLPCAT3
Cancer3DLPCAT3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611950   
Orphanet
DisGeNETLPCAT3
MedgenLPCAT3
Genetic Testing Registry LPCAT3
NextProtQ6P1A2 [Medical]
TSGene10162
GENETestsLPCAT3
Target ValidationLPCAT3
Huge Navigator LPCAT3 [HugePedia]
snp3D : Map Gene to Disease10162
BioCentury BCIQLPCAT3
ClinGenLPCAT3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10162
Chemical/Pharm GKB GenePA162394266
Clinical trialLPCAT3
Miscellaneous
canSAR (ICR)LPCAT3 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLPCAT3
EVEXLPCAT3
GoPubMedLPCAT3
iHOPLPCAT3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Aug 27 11:33:11 CEST 2018

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