LPCAT3 (lysophosphatidylcholine acyltransferase 3)

2003-12-01  

Identity

HGNC
LPCAT3
LOCATION
12p13.31
LOCUSID
10162
ALIAS
C3F,LPCAT,LPLAT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10162
MIM: 611950
HGNC: 30244
Ensembl: ENSG00000111684

Variants:

dbSNP: 10162
ClinVar: 10162
TCGA: ENSG00000111684
COSMIC: LPCAT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111684ENST00000261407Q6P1A2
ENSG00000111684ENST00000535479F5H0M4
ENSG00000111684ENST00000536797F5GYT3
ENSG00000111684ENST00000538910F5H680
ENSG00000111684ENST00000540090F5H7K7
ENSG00000111684ENST00000543794B7Z3N5

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Glycerophospholipid metabolismKEGGhsa00564
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Acyl chain remodelling of PEREACTOMER-HSA-1482839
Acyl chain remodelling of PCREACTOMER-HSA-1482788
Acyl chain remodelling of PSREACTOMER-HSA-1482801
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

References

Pubmed IDYearTitleCitations
187721282008Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils.55
181950192008Identification and characterization of a major liver lysophosphatidylcholine acyltransferase.54
187822252008Member of the membrane-bound O-acyltransferase (MBOAT) family encodes a lysophospholipid acyltransferase with broad substrate specificity.22
235801422013Liver x receptor regulates arachidonic acid distribution and eicosanoid release in human macrophages: a key role for lysophosphatidylcholine acyltransferase 3.18
200186182007Immunopathogenesis of dengue hemorrhagic fever and shock syndrome: role of TAP and HPA gene polymorphism.16
187813502008Substrate preferences of a lysophosphatidylcholine acyltransferase highlight its role in phospholipid remodeling.11
208371152011Regulation of LPCAT3 by LXR.9
193519712009Characterization of human lysophospholipid acyltransferase 3.8
279136212017Identification of Hepatic Lysophosphatidylcholine Acyltransferase 3 as a Novel Target Gene Regulated by Peroxisome Proliferator-activated Receptor δ.7
259949022015Essential Role of Lysophosphatidylcholine Acyltransferase 3 in the Induction of Macrophage Polarization in PMA-Treated U937 Cells.6

Citation

Dessen P

LPCAT3 (lysophosphatidylcholine acyltransferase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/887/lpcat3