Atlas of Genetics and Cytogenetics in Oncology and Haematology


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LPIN1 (lipin 1)

Identity

Alias_symbol (synonym)KIAA0188
Other aliasPAP1
HGNC (Hugo) LPIN1
LocusID (NCBI) 23175
Atlas_Id 54427
Location 2p25.1  [Link to chromosome band 2p25]
Location_base_pair Starts at 11724315 and ends at 11827407 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ANKS1B (12q23.1) / LPIN1 (2p25.1)ARGLU1 (13q33.3) / LPIN1 (2p25.1)ARL16 (17q25.3) / LPIN1 (2p25.1)
LPIN1 (2p25.1) / C3orf67 (3p14.2)LPIN1 (2p25.1) / LPIN1 (2p25.1)NTNG2 (9q34.13) / LPIN1 (2p25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LPIN1   13345
Cards
Entrez_Gene (NCBI)LPIN1  23175  lipin 1
AliasesPAP1
GeneCards (Weizmann)LPIN1
Ensembl hg19 (Hinxton)ENSG00000134324 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134324 [Gene_View]  chr2:11724315-11827407 [Contig_View]  LPIN1 [Vega]
ICGC DataPortalENSG00000134324
TCGA cBioPortalLPIN1
AceView (NCBI)LPIN1
Genatlas (Paris)LPIN1
WikiGenes23175
SOURCE (Princeton)LPIN1
Genetics Home Reference (NIH)LPIN1
Genomic and cartography
GoldenPath hg38 (UCSC)LPIN1  -     chr2:11724315-11827407 +  2p25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LPIN1  -     2p25.1   [Description]    (hg19-Feb_2009)
EnsemblLPIN1 - 2p25.1 [CytoView hg19]  LPIN1 - 2p25.1 [CytoView hg38]
Mapping of homologs : NCBILPIN1 [Mapview hg19]  LPIN1 [Mapview hg38]
OMIM268200   605518   
Gene and transcription
Genbank (Entrez)AF147446 AI379040 AK127039 AK290235 AK293787
RefSeq transcript (Entrez)NM_001261427 NM_001261428 NM_001261429 NM_001349199 NM_001349200 NM_001349201 NM_001349202 NM_001349203 NM_001349204 NM_001349205 NM_001349206 NM_001349207 NM_001349208 NM_145693
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LPIN1
Cluster EST : UnigeneHs.739141 [ NCBI ]
CGAP (NCI)Hs.739141
Alternative Splicing GalleryENSG00000134324
Gene ExpressionLPIN1 [ NCBI-GEO ]   LPIN1 [ EBI - ARRAY_EXPRESS ]   LPIN1 [ SEEK ]   LPIN1 [ MEM ]
Gene Expression Viewer (FireBrowse)LPIN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23175
GTEX Portal (Tissue expression)LPIN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14693   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14693  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14693
Splice isoforms : SwissVarQ14693
Catalytic activity : Enzyme3.1.3.4 [ Enzyme-Expasy ]   3.1.3.43.1.3.4 [ IntEnz-EBI ]   3.1.3.4 [ BRENDA ]   3.1.3.4 [ KEGG ]   
PhosPhoSitePlusQ14693
Domains : Interpro (EBI)HAD-like_dom    Lipin_mid    Lipin_N    LNS2    LNS2/PITP    LPIN1   
Domain families : Pfam (Sanger)Lipin_mid (PF16876)    Lipin_N (PF04571)    LNS2 (PF08235)   
Domain families : Pfam (NCBI)pfam16876    pfam04571    pfam08235   
Domain families : Smart (EMBL)LNS2 (SM00775)  
Conserved Domain (NCBI)LPIN1
DMDM Disease mutations23175
Blocks (Seattle)LPIN1
SuperfamilyQ14693
Human Protein AtlasENSG00000134324
Peptide AtlasQ14693
HPRD09271
IPIIPI01009658   IPI00909107   IPI00790250   IPI00032388   IPI00796961   IPI00788897   IPI00790924   IPI00789470   IPI00788867   
Protein Interaction databases
DIP (DOE-UCLA)Q14693
IntAct (EBI)Q14693
FunCoupENSG00000134324
BioGRIDLPIN1
STRING (EMBL)LPIN1
ZODIACLPIN1
Ontologies - Pathways
QuickGOQ14693
Ontology : AmiGOmolecular_function  transcription coactivator activity  nucleus  nucleus  nuclear envelope  nucleoplasm  cytoplasm  mitochondrial outer membrane  endoplasmic reticulum membrane  cytosol  transcription, DNA-templated  triglyceride mobilization  phosphatidylethanolamine biosynthetic process  phosphatidylcholine biosynthetic process  mitotic nuclear envelope disassembly  phosphatidate phosphatase activity  phosphatidate phosphatase activity  fatty acid catabolic process  fatty acid catabolic process  dephosphorylation  triglyceride biosynthetic process  triglyceride biosynthetic process  animal organ regeneration  nuclear membrane  cellular response to insulin stimulus  positive regulation of transcription from RNA polymerase II promoter  
Ontology : EGO-EBImolecular_function  transcription coactivator activity  nucleus  nucleus  nuclear envelope  nucleoplasm  cytoplasm  mitochondrial outer membrane  endoplasmic reticulum membrane  cytosol  transcription, DNA-templated  triglyceride mobilization  phosphatidylethanolamine biosynthetic process  phosphatidylcholine biosynthetic process  mitotic nuclear envelope disassembly  phosphatidate phosphatase activity  phosphatidate phosphatase activity  fatty acid catabolic process  fatty acid catabolic process  dephosphorylation  triglyceride biosynthetic process  triglyceride biosynthetic process  animal organ regeneration  nuclear membrane  cellular response to insulin stimulus  positive regulation of transcription from RNA polymerase II promoter  
Pathways : KEGGGlycerolipid metabolism    Glycerophospholipid metabolism   
NDEx NetworkLPIN1
Atlas of Cancer Signalling NetworkLPIN1
Wikipedia pathwaysLPIN1
Orthology - Evolution
OrthoDB23175
GeneTree (enSembl)ENSG00000134324
Phylogenetic Trees/Animal Genes : TreeFamLPIN1
HOVERGENQ14693
HOGENOMQ14693
Homologs : HomoloGeneLPIN1
Homology/Alignments : Family Browser (UCSC)LPIN1
Gene fusions - Rearrangements
Fusion : MitelmanLPIN1/C3orf67 [2p25.1/3p14.2]  
Fusion : MitelmanNTNG2/LPIN1 [9q34.13/2p25.1]  [t(2;9)(p25;q34)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLPIN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LPIN1
dbVarLPIN1
ClinVarLPIN1
1000_GenomesLPIN1 
Exome Variant ServerLPIN1
ExAC (Exome Aggregation Consortium)LPIN1 (select the gene name)
Genetic variants : HAPMAP23175
Genomic Variants (DGV)LPIN1 [DGVbeta]
DECIPHERLPIN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLPIN1 
Mutations
ICGC Data PortalLPIN1 
TCGA Data PortalLPIN1 
Broad Tumor PortalLPIN1
OASIS PortalLPIN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLPIN1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLPIN1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LPIN1
DgiDB (Drug Gene Interaction Database)LPIN1
DoCM (Curated mutations)LPIN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LPIN1 (select a term)
intoGenLPIN1
Cancer3DLPIN1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM268200    605518   
Orphanet14418   
MedgenLPIN1
Genetic Testing Registry LPIN1
NextProtQ14693 [Medical]
TSGene23175
GENETestsLPIN1
Target ValidationLPIN1
Huge Navigator LPIN1 [HugePedia]
snp3D : Map Gene to Disease23175
BioCentury BCIQLPIN1
ClinGenLPIN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23175
Chemical/Pharm GKB GenePA30436
Clinical trialLPIN1
Miscellaneous
canSAR (ICR)LPIN1 (select the gene name)
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLPIN1
EVEXLPIN1
GoPubMedLPIN1
iHOPLPIN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:41:28 CEST 2017

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