Atlas of Genetics and Cytogenetics in Oncology and Haematology

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LPL (lipoprotein lipase)

Identity

Alias (NCBI)HDLCQ11
LIPD
HGNC (Hugo) LPL
HGNC Previous nameLIPD
LocusID (NCBI) 4023
Atlas_Id 46016
Location 8p21.3  [Link to chromosome band 8p21]
Location_base_pair Starts at 19939253 and ends at 19967259 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PEX5 (12p13.31) / LPL (8p21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(8;12)(p21;p13) PEX5/LPL

External links

Nomenclature
HGNC (Hugo)LPL   6677
Cards
Entrez_Gene (NCBI)LPL    lipoprotein lipase
AliasesHDLCQ11; LIPD
GeneCards (Weizmann)LPL
Ensembl hg19 (Hinxton)ENSG00000175445 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175445 [Gene_View]  ENSG00000175445 [Sequence]  chr8:19939253-19967259 [Contig_View]  LPL [Vega]
ICGC DataPortalENSG00000175445
TCGA cBioPortalLPL
AceView (NCBI)LPL
Genatlas (Paris)LPL
SOURCE (Princeton)LPL
Genetics Home Reference (NIH)LPL
Genomic and cartography
GoldenPath hg38 (UCSC)LPL  -     chr8:19939253-19967259 +  8p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LPL  -     8p21.3   [Description]    (hg19-Feb_2009)
GoldenPathLPL - 8p21.3 [CytoView hg19]  LPL - 8p21.3 [CytoView hg38]
ImmunoBaseENSG00000175445
genome Data Viewer NCBILPL [Mapview hg19]  
OMIM144250   238600   609708   
Gene and transcription
Genbank (Entrez)AK092286 AK222464 AK290290 AK297164 AK312311
RefSeq transcript (Entrez)NM_000237
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LPL
Alternative Splicing GalleryENSG00000175445
Gene ExpressionLPL [ NCBI-GEO ]   LPL [ EBI - ARRAY_EXPRESS ]   LPL [ SEEK ]   LPL [ MEM ]
Gene Expression Viewer (FireBrowse)LPL [ Firebrowse - Broad ]
GenevisibleExpression of LPL in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4023
GTEX Portal (Tissue expression)LPL
Human Protein AtlasENSG00000175445-LPL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06858   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP06858  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP06858
Splice isoforms : SwissVarP06858
PhosPhoSitePlusP06858
Domaine pattern : Prosite (Expaxy)LIPASE_SER (PS00120)    PLAT (PS50095)   
Domains : Interpro (EBI)AB_hydrolase    Lipase/vitellogenin    Lipase_LIPH    Lipase_N    Lipo_Lipase    PLAT/LH2_dom    PLAT/LH2_dom_sf    TAG_lipase   
Domain families : Pfam (Sanger)Lipase (PF00151)    PLAT (PF01477)   
Domain families : Pfam (NCBI)pfam00151    pfam01477   
Domain families : Smart (EMBL)LH2 (SM00308)  
Conserved Domain (NCBI)LPL
Blocks (Seattle)LPL
PDB (RSDB)6E7K    6OAU    6OAZ    6OB0   
PDB Europe6E7K    6OAU    6OAZ    6OB0   
PDB (PDBSum)6E7K    6OAU    6OAZ    6OB0   
PDB (IMB)6E7K    6OAU    6OAZ    6OB0   
Structural Biology KnowledgeBase6E7K    6OAU    6OAZ    6OB0   
SCOP (Structural Classification of Proteins)6E7K    6OAU    6OAZ    6OB0   
CATH (Classification of proteins structures)6E7K    6OAU    6OAZ    6OB0   
SuperfamilyP06858
Human Protein Atlas [tissue]ENSG00000175445-LPL [tissue]
Peptide AtlasP06858
HPRD01999
IPIIPI00027847   IPI01011504   IPI00972962   IPI00981202   IPI00984529   IPI00973971   
Protein Interaction databases
DIP (DOE-UCLA)P06858
IntAct (EBI)P06858
BioGRIDLPL
STRING (EMBL)LPL
ZODIACLPL
Ontologies - Pathways
QuickGOP06858
Ontology : AmiGOretinoid metabolic process  lipoprotein lipase activity  lipoprotein lipase activity  lipoprotein lipase activity  lipoprotein lipase activity  phospholipase activity  phospholipase activity  triglyceride lipase activity  triglyceride lipase activity  signaling receptor binding  calcium ion binding  protein binding  extracellular region  extracellular space  extracellular space  extracellular space  plasma membrane  fatty acid metabolic process  fatty acid biosynthetic process  fatty acid biosynthetic process  fatty acid biosynthetic process  fatty acid biosynthetic process  triglyceride metabolic process  phospholipid metabolic process  heparin binding  phospholipase A1 activity  response to cold  response to bacterium  response to glucose  cell surface  positive regulation of macrophage derived foam cell differentiation  positive regulation of lipid storage  positive regulation of cholesterol storage  positive regulation of sequestering of triglyceride  lipid catabolic process  lipase activity  triglyceride binding  triglyceride biosynthetic process  triglyceride catabolic process  triglyceride catabolic process  triglyceride catabolic process  cellular response to nutrient  apolipoprotein binding  apolipoprotein binding  very-low-density lipoprotein particle  chylomicron remodeling  chylomicron remodeling  chylomicron remodeling  very-low-density lipoprotein particle remodeling  very-low-density lipoprotein particle remodeling  response to drug  chylomicron  cholesterol homeostasis  protein homodimerization activity  heparan sulfate proteoglycan binding  protein membrane anchor  positive regulation of fat cell differentiation  positive regulation of interleukin-1 beta secretion  positive regulation of inflammatory response  positive regulation of inflammatory response  regulation of lipoprotein lipase activity  phosphatidylserine 1-acylhydrolase activity  1-acyl-2-lysophosphatidylserine acylhydrolase activity  low-density lipoprotein particle mediated signaling  triglyceride homeostasis  cellular response to fatty acid  lipoprotein particle binding  positive regulation of chemokine secretion  negative regulation of cellular response to insulin stimulus  positive regulation of tumor necrosis factor secretion  positive regulation of chemokine (C-X-C motif) ligand 2 production  positive regulation of interleukin-6 secretion  
Ontology : EGO-EBIretinoid metabolic process  lipoprotein lipase activity  lipoprotein lipase activity  lipoprotein lipase activity  lipoprotein lipase activity  phospholipase activity  phospholipase activity  triglyceride lipase activity  triglyceride lipase activity  signaling receptor binding  calcium ion binding  protein binding  extracellular region  extracellular space  extracellular space  extracellular space  plasma membrane  fatty acid metabolic process  fatty acid biosynthetic process  fatty acid biosynthetic process  fatty acid biosynthetic process  fatty acid biosynthetic process  triglyceride metabolic process  phospholipid metabolic process  heparin binding  phospholipase A1 activity  response to cold  response to bacterium  response to glucose  cell surface  positive regulation of macrophage derived foam cell differentiation  positive regulation of lipid storage  positive regulation of cholesterol storage  positive regulation of sequestering of triglyceride  lipid catabolic process  lipase activity  triglyceride binding  triglyceride biosynthetic process  triglyceride catabolic process  triglyceride catabolic process  triglyceride catabolic process  cellular response to nutrient  apolipoprotein binding  apolipoprotein binding  very-low-density lipoprotein particle  chylomicron remodeling  chylomicron remodeling  chylomicron remodeling  very-low-density lipoprotein particle remodeling  very-low-density lipoprotein particle remodeling  response to drug  chylomicron  cholesterol homeostasis  protein homodimerization activity  heparan sulfate proteoglycan binding  protein membrane anchor  positive regulation of fat cell differentiation  positive regulation of interleukin-1 beta secretion  positive regulation of inflammatory response  positive regulation of inflammatory response  regulation of lipoprotein lipase activity  phosphatidylserine 1-acylhydrolase activity  1-acyl-2-lysophosphatidylserine acylhydrolase activity  low-density lipoprotein particle mediated signaling  triglyceride homeostasis  cellular response to fatty acid  lipoprotein particle binding  positive regulation of chemokine secretion  negative regulation of cellular response to insulin stimulus  positive regulation of tumor necrosis factor secretion  positive regulation of chemokine (C-X-C motif) ligand 2 production  positive regulation of interleukin-6 secretion  
Pathways : KEGGGlycerolipid metabolism    PPAR signaling pathway    Alzheimer's disease   
NDEx NetworkLPL
Atlas of Cancer Signalling NetworkLPL
Wikipedia pathwaysLPL
Orthology - Evolution
OrthoDB4023
GeneTree (enSembl)ENSG00000175445
Phylogenetic Trees/Animal Genes : TreeFamLPL
HOGENOMP06858
Homologs : HomoloGeneLPL
Homology/Alignments : Family Browser (UCSC)LPL
Gene fusions - Rearrangements
Fusion : MitelmanPEX5/LPL [12p13.31/8p21.3]  
Fusion : QuiverLPL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLPL [hg38]
dbVarLPL
ClinVarLPL
MonarchLPL
1000_GenomesLPL 
Exome Variant ServerLPL
GNOMAD BrowserENSG00000175445
Varsome BrowserLPL
Genomic Variants (DGV)LPL [DGVbeta]
DECIPHERLPL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLPL 
Mutations
ICGC Data PortalLPL 
TCGA Data PortalLPL 
Broad Tumor PortalLPL
OASIS PortalLPL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLPL  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLPL
Mutations and Diseases : HGMDLPL
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch LPL
DgiDB (Drug Gene Interaction Database)LPL
DoCM (Curated mutations)LPL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LPL (select a term)
intoGenLPL
Cancer3DLPL(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM144250    238600    609708   
Orphanet21336    10944   
DisGeNETLPL
MedgenLPL
Genetic Testing Registry LPL
NextProtP06858 [Medical]
GENETestsLPL
Target ValidationLPL
Huge Navigator LPL [HugePedia]
ClinGenLPL
Clinical trials, drugs, therapy
MyCancerGenomeLPL
Protein Interactions : CTD
Pharm GKB GenePA232
Pharm GKB PathwaysPA2031   
PharosP06858
Clinical trialLPL
Miscellaneous
canSAR (ICR)LPL (select the gene name)
HarmonizomeLPL
DataMed IndexLPL
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLPL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:23:18 CET 2021
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