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LPXN (leupaxin)

Identity

Alias (NCBI)LDPL
HGNC (Hugo) LPXN
HGNC Alias symbLDPL
LocusID (NCBI) 9404
Atlas_Id 47705
Location 11q12.1  [Link to chromosome band 11q12]
Location_base_pair Starts at 58526871 and ends at 58575917 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LPXN (11q12.1) / LAMA3 (18q11.2)LPXN (11q12.1) / PAM16 (16p13.3)LPXN (11q12.1) / RUNX1 (21q22.12)
PTPRJ (11p11.2) / LPXN (11q12.1)RUNX1 (21q22.12) / LPXN (11q12.1)ZFP91 (11q12.1) / LPXN (11q12.1)
ZFP91 11q12.1 / LPXN 11q12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Protein

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(11;21)(q21;q22) RUNX1/LPXN
t(11;12)(q12;p13) ETV6/LPXN


External links

 

Nomenclature
HGNC (Hugo)LPXN   14061
Cards
Entrez_Gene (NCBI)LPXN    leupaxin
AliasesLDPL
GeneCards (Weizmann)LPXN
Ensembl hg19 (Hinxton)ENSG00000110031 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110031 [Gene_View]  ENSG00000110031 [Sequence]  chr11:58526871-58575917 [Contig_View]  LPXN [Vega]
ICGC DataPortalENSG00000110031
TCGA cBioPortalLPXN
AceView (NCBI)LPXN
Genatlas (Paris)LPXN
SOURCE (Princeton)LPXN
Genetics Home Reference (NIH)LPXN
Genomic and cartography
GoldenPath hg38 (UCSC)LPXN  -     chr11:58526871-58575917 -  11q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LPXN  -     11q12.1   [Description]    (hg19-Feb_2009)
GoldenPathLPXN - 11q12.1 [CytoView hg19]  LPXN - 11q12.1 [CytoView hg38]
ImmunoBaseENSG00000110031
Genome Data Viewer NCBILPXN [Mapview hg19]  
OMIM605390   
Gene and transcription
Genbank (Entrez)AA848029 AF062075 AK223165 AK299264 AK300955
RefSeq transcript (Entrez)NM_001143995 NM_001307951 NM_004811
Consensus coding sequences : CCDS (NCBI)LPXN
Gene ExpressionLPXN [ NCBI-GEO ]   LPXN [ EBI - ARRAY_EXPRESS ]   LPXN [ SEEK ]   LPXN [ MEM ]
Gene Expression Viewer (FireBrowse)LPXN [ Firebrowse - Broad ]
GenevisibleExpression of LPXN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9404
GTEX Portal (Tissue expression)LPXN
Human Protein AtlasENSG00000110031-LPXN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60711   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60711  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60711
PhosPhoSitePlusO60711
Domaine pattern : Prosite (Expaxy)LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)   
Domains : Interpro (EBI)Tgfb1i1/Leupaxin/TGFB1I1    Znf_LIM   
Domain families : Pfam (Sanger)LIM (PF00412)   
Domain families : Pfam (NCBI)pfam00412   
Domain families : Smart (EMBL)LIM (SM00132)  
Conserved Domain (NCBI)LPXN
PDB (RSDB)1X3H    4XEF    4XEK    4XEV   
PDB Europe1X3H    4XEF    4XEK    4XEV   
PDB (PDBSum)1X3H    4XEF    4XEK    4XEV   
PDB (IMB)1X3H    4XEF    4XEK    4XEV   
Structural Biology KnowledgeBase1X3H    4XEF    4XEK    4XEV   
SCOP (Structural Classification of Proteins)1X3H    4XEF    4XEK    4XEV   
CATH (Classification of proteins structures)1X3H    4XEF    4XEK    4XEV   
SuperfamilyO60711
AlphaFold pdb e-kbO60711   
Human Protein Atlas [tissue]ENSG00000110031-LPXN [tissue]
HPRD05651
Protein Interaction databases
DIP (DOE-UCLA)O60711
IntAct (EBI)O60711
BioGRIDLPXN
STRING (EMBL)LPXN
ZODIACLPXN
Ontologies - Pathways
QuickGOO60711
Ontology : AmiGOpodosome  transcription coregulator activity  transcription coregulator activity  protein binding  nucleus  cytoplasm  cytosol  cytosol  plasma membrane  plasma membrane  focal adhesion  focal adhesion  regulation of transcription, DNA-templated  cell adhesion  negative regulation of cell adhesion  signal transduction  transforming growth factor beta receptor signaling pathway  membrane  nuclear speck  regulation of cell adhesion mediated by integrin  substrate adhesion-dependent cell spreading  cell projection  endothelial cell migration  metal ion binding  perinuclear region of cytoplasm  negative regulation of B cell receptor signaling pathway  negative regulation of B cell receptor signaling pathway  protein-containing complex assembly  
Ontology : EGO-EBIpodosome  transcription coregulator activity  transcription coregulator activity  protein binding  nucleus  cytoplasm  cytosol  cytosol  plasma membrane  plasma membrane  focal adhesion  focal adhesion  regulation of transcription, DNA-templated  cell adhesion  negative regulation of cell adhesion  signal transduction  transforming growth factor beta receptor signaling pathway  membrane  nuclear speck  regulation of cell adhesion mediated by integrin  substrate adhesion-dependent cell spreading  cell projection  endothelial cell migration  metal ion binding  perinuclear region of cytoplasm  negative regulation of B cell receptor signaling pathway  negative regulation of B cell receptor signaling pathway  protein-containing complex assembly  
NDEx NetworkLPXN
Atlas of Cancer Signalling NetworkLPXN
Wikipedia pathwaysLPXN
Orthology - Evolution
OrthoDB9404
GeneTree (enSembl)ENSG00000110031
Phylogenetic Trees/Animal Genes : TreeFamLPXN
Homologs : HomoloGeneLPXN
Homology/Alignments : Family Browser (UCSC)LPXN
Gene fusions - Rearrangements
Fusion : MitelmanRUNX1/LPXN [21q22.12/11q12.1]  
Fusion : MitelmanZFP91/LPXN [11q12.1/11q12.1]  
Fusion : QuiverLPXN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLPXN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LPXN
dbVarLPXN
ClinVarLPXN
MonarchLPXN
1000_GenomesLPXN 
Exome Variant ServerLPXN
GNOMAD BrowserENSG00000110031
Varsome BrowserLPXN
ACMGLPXN variants
VarityO60711
Genomic Variants (DGV)LPXN [DGVbeta]
DECIPHERLPXN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLPXN 
Mutations
ICGC Data PortalLPXN 
TCGA Data PortalLPXN 
Broad Tumor PortalLPXN
OASIS PortalLPXN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLPXN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLPXN
Mutations and Diseases : HGMDLPXN
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLPXN
DgiDB (Drug Gene Interaction Database)LPXN
DoCM (Curated mutations)LPXN
CIViC (Clinical Interpretations of Variants in Cancer)LPXN
Cancer3DLPXN
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605390   
Orphanet
DisGeNETLPXN
MedgenLPXN
Genetic Testing Registry LPXN
NextProtO60711 [Medical]
GENETestsLPXN
Target ValidationLPXN
Huge Navigator LPXN [HugePedia]
ClinGenLPXN
Clinical trials, drugs, therapy
MyCancerGenomeLPXN
Protein Interactions : CTDLPXN
Pharm GKB GenePA30441
PharosO60711
Clinical trialLPXN
Miscellaneous
canSAR (ICR)LPXN
HarmonizomeLPXN
DataMed IndexLPXN
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLPXN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:17:02 CEST 2021

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