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LPXN (leupaxin)

Identity

Other namesLDPL
HGNC (Hugo) LPXN
LocusID (NCBI) 9404
Atlas_Id 47705
Location 11q12.1
Location_base_pair Starts at 58294344 and ends at 58345712 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LPXN (11q12.1) / LAMA3 (18q11.2)LPXN (11q12.1) / PAM16 (16p13.3)LPXN (11q12.1) / RUNX1 (21q22.12)
PTPRJ (11p11.2) / LPXN (11q12.1)RUNX1 (21q22.12) / LPXN (11q12.1)ZFP91 (11q12.1) / LPXN (11q12.1)
ZFP91 11q12.1 / LPXN 11q12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Protein

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;21)(q21;q22) RUNX1/LPXN

External links

Nomenclature
HGNC (Hugo)LPXN   14061
Cards
Entrez_Gene (NCBI)LPXN  9404  leupaxin
AliasesLDPL
GeneCards (Weizmann)LPXN
Ensembl hg19 (Hinxton)ENSG00000110031 [Gene_View]  chr11:58294344-58345712 [Contig_View]  LPXN [Vega]
Ensembl hg38 (Hinxton)ENSG00000110031 [Gene_View]  chr11:58294344-58345712 [Contig_View]  LPXN [Vega]
ICGC DataPortalENSG00000110031
TCGA cBioPortalLPXN
AceView (NCBI)LPXN
Genatlas (Paris)LPXN
WikiGenes9404
SOURCE (Princeton)LPXN
Genomic and cartography
GoldenPath hg19 (UCSC)LPXN  -     chr11:58294344-58345712 -  11q12.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LPXN  -     11q12.1   [Description]    (hg38-Dec_2013)
EnsemblLPXN - 11q12.1 [CytoView hg19]  LPXN - 11q12.1 [CytoView hg38]
Mapping of homologs : NCBILPXN [Mapview hg19]  LPXN [Mapview hg38]
OMIM605390   
Gene and transcription
Genbank (Entrez)AA848029 AF062075 AK223165 AK299264 AK300955
RefSeq transcript (Entrez)NM_001143995 NM_001307951 NM_004811
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)LPXN
Cluster EST : UnigeneHs.125474 [ NCBI ]
CGAP (NCI)Hs.125474
Alternative Splicing GalleryENSG00000110031
Gene ExpressionLPXN [ NCBI-GEO ]   LPXN [ EBI - ARRAY_EXPRESS ]   LPXN [ SEEK ]   LPXN [ MEM ]
Gene Expression Viewer (FireBrowse)LPXN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9404
GTEX Portal (Tissue expression)LPXN
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60711 (Uniprot)
NextProtO60711  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60711
Splice isoforms : SwissVarO60711 (Swissvar)
PhosPhoSitePlusO60711
Domaine pattern : Prosite (Expaxy)LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)   
Domains : Interpro (EBI)Tgfb1i1/Leupaxin    Znf_LIM   
Domain families : Pfam (Sanger)LIM (PF00412)   
Domain families : Pfam (NCBI)pfam00412   
Domain families : Smart (EMBL)LIM (SM00132)  
DMDM Disease mutations9404
Blocks (Seattle)LPXN
PDB (SRS)1X3H    4XEF    4XEK    4XEV   
PDB (PDBSum)1X3H    4XEF    4XEK    4XEV   
PDB (IMB)1X3H    4XEF    4XEK    4XEV   
PDB (RSDB)1X3H    4XEF    4XEK    4XEV   
Structural Biology KnowledgeBase1X3H    4XEF    4XEK    4XEV   
SCOP (Structural Classification of Proteins)1X3H    4XEF    4XEK    4XEV   
CATH (Classification of proteins structures)1X3H    4XEF    4XEK    4XEV   
SuperfamilyO60711
Human Protein AtlasENSG00000110031
Peptide AtlasO60711
HPRD05651
IPIIPI00299066   IPI00871430   IPI00983292   
Protein Interaction databases
DIP (DOE-UCLA)O60711
IntAct (EBI)O60711
FunCoupENSG00000110031
BioGRIDLPXN
STRING (EMBL)LPXN
ZODIACLPXN
Ontologies - Pathways
QuickGOO60711
Ontology : AmiGOpodosome  transcription cofactor activity  protein binding  nucleus  cytoplasm  plasma membrane  focal adhesion  transcription, DNA-templated  regulation of transcription, DNA-templated  protein complex assembly  cell adhesion  negative regulation of cell adhesion  signal transduction  zinc ion binding  membrane  regulation of cell adhesion mediated by integrin  cell projection  perinuclear region of cytoplasm  negative regulation of B cell receptor signaling pathway  
Ontology : EGO-EBIpodosome  transcription cofactor activity  protein binding  nucleus  cytoplasm  plasma membrane  focal adhesion  transcription, DNA-templated  regulation of transcription, DNA-templated  protein complex assembly  cell adhesion  negative regulation of cell adhesion  signal transduction  zinc ion binding  membrane  regulation of cell adhesion mediated by integrin  cell projection  perinuclear region of cytoplasm  negative regulation of B cell receptor signaling pathway  
NDEx Network
Atlas of Cancer Signalling NetworkLPXN
Wikipedia pathwaysLPXN
Orthology - Evolution
OrthoDB9404
GeneTree (enSembl)ENSG00000110031
Phylogenetic Trees/Animal Genes : TreeFamLPXN
Homologs : HomoloGeneLPXN
Homology/Alignments : Family Browser (UCSC)LPXN
Gene fusions - Rearrangements
Fusion: TCGAZFP91 11q12.1 LPXN 11q12.1 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerLPXN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LPXN
dbVarLPXN
ClinVarLPXN
1000_GenomesLPXN 
Exome Variant ServerLPXN
ExAC (Exome Aggregation Consortium)LPXN (select the gene name)
Genetic variants : HAPMAP9404
Genomic Variants (DGV)LPXN [DGVbeta]
Mutations
ICGC Data PortalLPXN 
TCGA Data PortalLPXN 
Broad Tumor PortalLPXN
OASIS PortalLPXN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLPXN 
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch LPXN
DgiDB (Drug Gene Interaction Database)LPXN
DoCM (Curated mutations)LPXN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LPXN (select a term)
intoGenLPXN
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:58294344-58345712  ENSG00000110031
CONAN: Copy Number AnalysisLPXN 
Mutations and Diseases : HGMDLPXN
OMIM605390   
MedgenLPXN
Genetic Testing Registry LPXN
NextProtO60711 [Medical]
TSGene9404
GENETestsLPXN
Huge Navigator LPXN [HugePedia]
snp3D : Map Gene to Disease9404
BioCentury BCIQLPXN
ClinGenLPXN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9404
Chemical/Pharm GKB GenePA30441
Clinical trialLPXN
Miscellaneous
canSAR (ICR)LPXN (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLPXN
EVEXLPXN
GoPubMedLPXN
iHOPLPXN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:09:30 CEST 2016

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