Atlas of Genetics and Cytogenetics in Oncology and Haematology


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LPXN (leupaxin)

Identity

Other namesLDPL
HGNC (Hugo) LPXN
LocusID (NCBI) 9404
Atlas_Id 47705
Location 11q12.1
Location_base_pair Starts at 58294344 and ends at 58345639 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Protein

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615

External links

Nomenclature
HGNC (Hugo)LPXN   14061
Cards
Entrez_Gene (NCBI)LPXN  9404  leupaxin
GeneCards (Weizmann)LPXN
Ensembl hg19 (Hinxton)ENSG00000110031 [Gene_View]  chr11:58294344-58345639 [Contig_View]  LPXN [Vega]
Ensembl hg38 (Hinxton)ENSG00000110031 [Gene_View]  chr11:58294344-58345639 [Contig_View]  LPXN [Vega]
ICGC DataPortalENSG00000110031
TCGA cBioPortalLPXN
AceView (NCBI)LPXN
Genatlas (Paris)LPXN
WikiGenes9404
SOURCE (Princeton)LPXN
Genomic and cartography
GoldenPath hg19 (UCSC)LPXN  -     chr11:58294344-58345639 -  11q12.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LPXN  -     11q12.1   [Description]    (hg38-Dec_2013)
EnsemblLPXN - 11q12.1 [CytoView hg19]  LPXN - 11q12.1 [CytoView hg38]
Mapping of homologs : NCBILPXN [Mapview hg19]  LPXN [Mapview hg38]
OMIM605390   
Gene and transcription
Genbank (Entrez)AF062075 AK223165 AK299264 AK300955 AK301093
RefSeq transcript (Entrez)NM_001143995 NM_004811
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)LPXN
Cluster EST : UnigeneHs.125474 [ NCBI ]
CGAP (NCI)Hs.125474
Alternative Splicing : Fast-db (Paris)GSHG0005792
Alternative Splicing GalleryENSG00000110031
Gene ExpressionLPXN [ NCBI-GEO ]     LPXN [ SEEK ]   LPXN [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60711 (Uniprot)
NextProtO60711  [Medical]
With graphics : InterProO60711
Splice isoforms : SwissVarO60711 (Swissvar)
Domaine pattern : Prosite (Expaxy)LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)   
Domains : Interpro (EBI)Tgfb1i1/Leupaxin    Znf_LIM   
Related proteins : CluSTrO60711
Domain families : Pfam (Sanger)LIM (PF00412)   
Domain families : Pfam (NCBI)pfam00412   
Domain families : Smart (EMBL)LIM (SM00132)  
DMDM Disease mutations9404
Blocks (Seattle)O60711
PDB (SRS)1X3H   
PDB (PDBSum)1X3H   
PDB (IMB)1X3H   
PDB (RSDB)1X3H   
Human Protein AtlasENSG00000110031
Peptide AtlasO60711
HPRD05651
IPIIPI00299066   IPI00871430   IPI00983292   
Protein Interaction databases
DIP (DOE-UCLA)O60711
IntAct (EBI)O60711
FunCoupENSG00000110031
BioGRIDLPXN
IntegromeDBLPXN
STRING (EMBL)LPXN
Ontologies - Pathways
QuickGOO60711
Ontology : AmiGOpodosome  transcription cofactor activity  protein binding  nucleus  cytoplasm  plasma membrane  focal adhesion  transcription, DNA-templated  regulation of transcription, DNA-templated  protein complex assembly  cell adhesion  negative regulation of cell adhesion  signal transduction  zinc ion binding  membrane  regulation of cell adhesion mediated by integrin  cell projection  perinuclear region of cytoplasm  negative regulation of B cell receptor signaling pathway  
Ontology : EGO-EBIpodosome  transcription cofactor activity  protein binding  nucleus  cytoplasm  plasma membrane  focal adhesion  transcription, DNA-templated  regulation of transcription, DNA-templated  protein complex assembly  cell adhesion  negative regulation of cell adhesion  signal transduction  zinc ion binding  membrane  regulation of cell adhesion mediated by integrin  cell projection  perinuclear region of cytoplasm  negative regulation of B cell receptor signaling pathway  
Protein Interaction DatabaseLPXN
DoCM (Curated mutations)LPXN
Wikipedia pathwaysLPXN
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerLPXN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LPXN
dbVarLPXN
ClinVarLPXN
1000_GenomesLPXN 
Exome Variant ServerLPXN
SNP (GeneSNP Utah)LPXN
SNP : HGBaseLPXN
Genetic variants : HAPMAPLPXN
Genomic Variants (DGV)LPXN [DGVbeta]
Mutations
ICGC Data PortalLPXN 
TCGA Data PortalLPXN 
Tumor PortalLPXN
Somatic Mutations in Cancer : COSMICLPXN 
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:58294344-58345639
CONAN: Copy Number AnalysisLPXN 
Mutations and Diseases : HGMDLPXN
OMIM605390   
MedgenLPXN
NextProtO60711 [Medical]
GENETestsLPXN
Disease Genetic AssociationLPXN
Huge Navigator LPXN [HugePedia]  LPXN [HugeCancerGEM]
snp3D : Map Gene to Disease9404
DGIdb (Drug Gene Interaction db)LPXN
General knowledge
Homologs : HomoloGeneLPXN
Homology/Alignments : Family Browser (UCSC)LPXN
Phylogenetic Trees/Animal Genes : TreeFamLPXN
Chemical/Protein Interactions : CTD9404
Chemical/Pharm GKB GenePA30441
Clinical trialLPXN
Cancer Resource (Charite)ENSG00000110031
Other databases
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
CoreMineLPXN
GoPubMedLPXN
iHOPLPXN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Apr 13 14:43:15 CEST 2015

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