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LRAT (lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase))

Identity

Alias_symbol (synonym)LCA14
Other alias
HGNC (Hugo) LRAT
LocusID (NCBI) 9227
Atlas_Id 43955
Location 4q32.1  [Link to chromosome band 4q32]
Location_base_pair Starts at 154740841 and ends at 154753119 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AVL9 (7p14.3) / LRAT (4q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LRAT   6685
Cards
Entrez_Gene (NCBI)LRAT  9227  lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
AliasesLCA14
GeneCards (Weizmann)LRAT
Ensembl hg19 (Hinxton)ENSG00000121207 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000121207 [Gene_View]  chr4:154740841-154753119 [Contig_View]  LRAT [Vega]
ICGC DataPortalENSG00000121207
TCGA cBioPortalLRAT
AceView (NCBI)LRAT
Genatlas (Paris)LRAT
WikiGenes9227
SOURCE (Princeton)LRAT
Genetics Home Reference (NIH)LRAT
Genomic and cartography
GoldenPath hg38 (UCSC)LRAT  -     chr4:154740841-154753119 +  4q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LRAT  -     4q32.1   [Description]    (hg19-Feb_2009)
EnsemblLRAT - 4q32.1 [CytoView hg19]  LRAT - 4q32.1 [CytoView hg38]
Mapping of homologs : NCBILRAT [Mapview hg19]  LRAT [Mapview hg38]
OMIM268000   604863   613341   
Gene and transcription
Genbank (Entrez)AF071510 AK056234 AK292598 AY546085 AY546086
RefSeq transcript (Entrez)NM_001301645 NM_004744
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LRAT
Cluster EST : UnigeneHs.736130 [ NCBI ]
CGAP (NCI)Hs.736130
Alternative Splicing GalleryENSG00000121207
Gene ExpressionLRAT [ NCBI-GEO ]   LRAT [ EBI - ARRAY_EXPRESS ]   LRAT [ SEEK ]   LRAT [ MEM ]
Gene Expression Viewer (FireBrowse)LRAT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9227
GTEX Portal (Tissue expression)LRAT
Human Protein AtlasENSG00000121207-LRAT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95237   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95237  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95237
Splice isoforms : SwissVarO95237
Catalytic activity : Enzyme2.3.1.135 [ Enzyme-Expasy ]   2.3.1.1352.3.1.135 [ IntEnz-EBI ]   2.3.1.135 [ BRENDA ]   2.3.1.135 [ KEGG ]   
PhosPhoSitePlusO95237
Domains : Interpro (EBI)LRAT-like_dom   
Domain families : Pfam (Sanger)LRAT (PF04970)   
Domain families : Pfam (NCBI)pfam04970   
Conserved Domain (NCBI)LRAT
DMDM Disease mutations9227
Blocks (Seattle)LRAT
SuperfamilyO95237
Human Protein Atlas [tissue]ENSG00000121207-LRAT [tissue]
Peptide AtlasO95237
HPRD05332
IPIIPI00006231   IPI00965174   
Protein Interaction databases
DIP (DOE-UCLA)O95237
IntAct (EBI)O95237
FunCoupENSG00000121207
BioGRIDLRAT
STRING (EMBL)LRAT
ZODIACLRAT
Ontologies - Pathways
QuickGOO95237
Ontology : AmiGOretinoid metabolic process  retinoic acid binding  multivesicular body  endoplasmic reticulum membrane  rough endoplasmic reticulum  vitamin A metabolic process  visual perception  integral component of membrane  O-palmitoyltransferase activity  transferase activity, transferring acyl groups  retinol binding  positive regulation of lipid transport  retinol metabolic process  retinoic acid metabolic process  phosphatidylcholine-retinol O-acyltransferase activity  perinuclear region of cytoplasm  response to stimulus  lecithin:11-cis retinol acyltransferase activity  
Ontology : EGO-EBIretinoid metabolic process  retinoic acid binding  multivesicular body  endoplasmic reticulum membrane  rough endoplasmic reticulum  vitamin A metabolic process  visual perception  integral component of membrane  O-palmitoyltransferase activity  transferase activity, transferring acyl groups  retinol binding  positive regulation of lipid transport  retinol metabolic process  retinoic acid metabolic process  phosphatidylcholine-retinol O-acyltransferase activity  perinuclear region of cytoplasm  response to stimulus  lecithin:11-cis retinol acyltransferase activity  
Pathways : KEGGRetinol metabolism    Vitamin digestion and absorption   
NDEx NetworkLRAT
Atlas of Cancer Signalling NetworkLRAT
Wikipedia pathwaysLRAT
Orthology - Evolution
OrthoDB9227
GeneTree (enSembl)ENSG00000121207
Phylogenetic Trees/Animal Genes : TreeFamLRAT
HOVERGENO95237
HOGENOMO95237
Homologs : HomoloGeneLRAT
Homology/Alignments : Family Browser (UCSC)LRAT
Gene fusions - Rearrangements
Tumor Fusion PortalLRAT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRAT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRAT
dbVarLRAT
ClinVarLRAT
1000_GenomesLRAT 
Exome Variant ServerLRAT
ExAC (Exome Aggregation Consortium)ENSG00000121207
GNOMAD BrowserENSG00000121207
Genetic variants : HAPMAP9227
Genomic Variants (DGV)LRAT [DGVbeta]
DECIPHERLRAT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLRAT 
Mutations
ICGC Data PortalLRAT 
TCGA Data PortalLRAT 
Broad Tumor PortalLRAT
OASIS PortalLRAT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRAT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLRAT
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
BioMutasearch LRAT
DgiDB (Drug Gene Interaction Database)LRAT
DoCM (Curated mutations)LRAT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRAT (select a term)
intoGenLRAT
Cancer3DLRAT(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM268000    604863    613341   
Orphanet659    3243    22365   
DisGeNETLRAT
MedgenLRAT
Genetic Testing Registry LRAT
NextProtO95237 [Medical]
TSGene9227
GENETestsLRAT
Target ValidationLRAT
Huge Navigator LRAT [HugePedia]
snp3D : Map Gene to Disease9227
BioCentury BCIQLRAT
ClinGenLRAT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9227
Chemical/Pharm GKB GenePA30443
Clinical trialLRAT
Miscellaneous
canSAR (ICR)LRAT (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRAT
EVEXLRAT
GoPubMedLRAT
iHOPLRAT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:20:52 CET 2017

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