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LRCH4 (leucine rich repeats and calponin homology domain containing 4)

Identity

Alias_namesLRN
LRRN1
leucine-rich repeats and calponin homology (CH) domain containing 4
Other aliasLRRN4
PP14183
HGNC (Hugo) LRCH4
LocusID (NCBI) 4034
Atlas_Id 68574
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 100574011 and ends at 100586188 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LRCH4 (7q22.1) / TBC1D1 (4p14)OXR1 (8q23.1) / LRCH4 (7q22.1)SEC31A (4q21.22) / LRCH4 (7q22.1)
TNKS1BP1 (11q12.1) / LRCH4 (7q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LRCH4   6691
Cards
Entrez_Gene (NCBI)LRCH4  4034  leucine rich repeats and calponin homology domain containing 4
AliasesLRN; LRRN1; LRRN4; PP14183
GeneCards (Weizmann)LRCH4
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr7:100574011-100586188 [Contig_View]  LRCH4 [Vega]
TCGA cBioPortalLRCH4
AceView (NCBI)LRCH4
Genatlas (Paris)LRCH4
WikiGenes4034
SOURCE (Princeton)LRCH4
Genetics Home Reference (NIH)LRCH4
Genomic and cartography
GoldenPath hg38 (UCSC)LRCH4  -     chr7:100574011-100586188 -  7q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LRCH4  -     7q22.1   [Description]    (hg19-Feb_2009)
EnsemblLRCH4 - 7q22.1 [CytoView hg19]  LRCH4 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBILRCH4 [Mapview hg19]  LRCH4 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF459638 AI491709 AK074833 AK097420 AK128189
RefSeq transcript (Entrez)NM_001289934 NM_002319
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LRCH4
Cluster EST : UnigeneHs.125742 [ NCBI ]
CGAP (NCI)Hs.125742
Gene ExpressionLRCH4 [ NCBI-GEO ]   LRCH4 [ EBI - ARRAY_EXPRESS ]   LRCH4 [ SEEK ]   LRCH4 [ MEM ]
Gene Expression Viewer (FireBrowse)LRCH4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4034
GTEX Portal (Tissue expression)LRCH4
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75427   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75427  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75427
Splice isoforms : SwissVarO75427
PhosPhoSitePlusO75427
Domaine pattern : Prosite (Expaxy)CH (PS50021)    LRR (PS51450)   
Domains : Interpro (EBI)CH-domain    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp   
Domain families : Pfam (Sanger)CH (PF00307)    LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam00307    pfam13855   
Domain families : Smart (EMBL)CH (SM00033)  LRR_TYP (SM00369)  
Conserved Domain (NCBI)LRCH4
DMDM Disease mutations4034
Blocks (Seattle)LRCH4
SuperfamilyO75427
Peptide AtlasO75427
HPRD10062
IPIIPI00000173   IPI00902958   IPI00945129   IPI00945006   
Protein Interaction databases
DIP (DOE-UCLA)O75427
IntAct (EBI)O75427
BioGRIDLRCH4
STRING (EMBL)LRCH4
ZODIACLRCH4
Ontologies - Pathways
QuickGOO75427
Ontology : AmiGOprotein binding  cytoplasm  signal transduction  nervous system development  basolateral plasma membrane  PML body  maintenance of epithelial cell apical/basal polarity  
Ontology : EGO-EBIprotein binding  cytoplasm  signal transduction  nervous system development  basolateral plasma membrane  PML body  maintenance of epithelial cell apical/basal polarity  
NDEx NetworkLRCH4
Atlas of Cancer Signalling NetworkLRCH4
Wikipedia pathwaysLRCH4
Orthology - Evolution
OrthoDB4034
Phylogenetic Trees/Animal Genes : TreeFamLRCH4
HOVERGENO75427
HOGENOMO75427
Homologs : HomoloGeneLRCH4
Homology/Alignments : Family Browser (UCSC)LRCH4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRCH4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRCH4
dbVarLRCH4
ClinVarLRCH4
1000_GenomesLRCH4 
Exome Variant ServerLRCH4
ExAC (Exome Aggregation Consortium)LRCH4 (select the gene name)
Genetic variants : HAPMAP4034
Genomic Variants (DGV)LRCH4 [DGVbeta]
DECIPHERLRCH4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLRCH4 
Mutations
ICGC Data PortalLRCH4 
TCGA Data PortalLRCH4 
Broad Tumor PortalLRCH4
OASIS PortalLRCH4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRCH4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLRCH4
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch LRCH4
DgiDB (Drug Gene Interaction Database)LRCH4
DoCM (Curated mutations)LRCH4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRCH4 (select a term)
intoGenLRCH4
Cancer3DLRCH4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenLRCH4
Genetic Testing Registry LRCH4
NextProtO75427 [Medical]
TSGene4034
GENETestsLRCH4
Target ValidationLRCH4
Huge Navigator LRCH4 [HugePedia]
snp3D : Map Gene to Disease4034
BioCentury BCIQLRCH4
ClinGenLRCH4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4034
Chemical/Pharm GKB GenePA30467
Clinical trialLRCH4
Miscellaneous
canSAR (ICR)LRCH4 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRCH4
EVEXLRCH4
GoPubMedLRCH4
iHOPLRCH4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:26:24 CEST 2017

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