LRFN2 (leucine rich repeat and fibronectin type III domain containing 2)

2014-11-01  

Identity

HGNC
LOCATION
6p21.2
LOCUSID
ALIAS
FIGLER2,KIAA1246,SALM1
FUSION GENES

Other Information

Locus ID:

NCBI: 57497
MIM: 612808
HGNC: 21226
Ensembl: ENSG00000156564

Variants:

dbSNP: 57497
ClinVar: 57497
TCGA: ENSG00000156564
COSMIC: LRFN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156564ENST00000338305Q9ULH4

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
SALM protein interactions at the synapsesREACTOMER-HSA-8849932
Protein-protein interactions at synapsesREACTOMER-HSA-6794362

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
264864732016Heterozygous deletion of the LRFN2 gene is associated with working memory deficits.7
221744182012Dileucine and PDZ-binding motifs mediate synaptic adhesion-like molecule 1 (SALM1) trafficking in hippocampal neurons.5
310531152019Intronic polymorphisms in genes LRFN2 (rs2494938) and DNAH11 (rs2285947) are prognostic indicators of esophageal squamous cell carcinoma.0
316056282020Genetic variants of DNAH11 and LRFN2 genes and their association with ovarian and breast cancer.0

Citation

Dessen P

LRFN2 (leucine rich repeat and fibronectin type III domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68577/lrfn2