LRFN4 (leucine rich repeat and fibronectin type III domain containing 4)

2021-06-01  

Identity

HGNC
LOCATION
11q13.2
LOCUSID
ALIAS
FIGLER6,SALM3,SALM3.

Other Information

Locus ID:

NCBI: 78999
MIM: 612810
HGNC: 28456
Ensembl: ENSG00000173621

Variants:

dbSNP: 78999
ClinVar: 78999
TCGA: ENSG00000173621
COSMIC: LRFN4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173621ENST00000309602Q6PJG9
ENSG00000173621ENST00000309602A0A024R5I6
ENSG00000173621ENST00000393952E7ENX6

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
SALM protein interactions at the synapsesREACTOMER-HSA-8849932
Protein-protein interactions at synapsesREACTOMER-HSA-6794362

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
263216372015Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion.29
226771682012A neuronal transmembrane protein LRFN4 complexes with 14-3-3s and NCK1 to induce morphological change in monocytic cells via Rac1-mediated actin cytoskeleton reorganization.7
217046182011A neuronal transmembrane protein LRFN4 induces monocyte/macrophage migration via actin cytoskeleton reorganization.5
310893992019High SALM3 Expression in Tumor Cells and Fibroblasts Is Correlated with Poor Prognosis in Gastric Cancer Patients.0

Citation

Dessen P

LRFN4 (leucine rich repeat and fibronectin type III domain containing 4)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58231/lrfn4