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LRP1 (LDL receptor related protein 1)

Identity

Other namesA2MR
APOER
APR
CD91
IGFBP3R
LRP
LRP1A
TGFBR5
HGNC (Hugo) LRP1
LocusID (NCBI) 4035
Atlas_Id 41199
Location 12q13.3
Location_base_pair Starts at 57522282 and ends at 57607125 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
HBP1 (7q22.3) / LRP1 (12q13.3)LRP1 (12q13.3) / LRP1 (12q13.3)LRP1 (12q13.3) / NEMP1 (12q13.3)
LRP1 (12q13.3) / SNRNP25 (16p13.3)LRP1 (12q13.3) / XPO5 (6p21.1)LRP1 (12q13.3) / ZNF3 (7q22.1)
SLPI (20q13.12) / LRP1 (12q13.3)ZNF692 (1q44) / LRP1 (12q13.3)LRP1 12q13.3 TMEM194A
LRP1 12q13.3 / XPO5 6p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LRP1   6692
Cards
Entrez_Gene (NCBI)LRP1  4035  LDL receptor related protein 1
AliasesA2MR; APOER; APR; CD91; 
IGFBP3R; LRP; LRP1A; TGFBR5
GeneCards (Weizmann)LRP1
Ensembl hg19 (Hinxton)ENSG00000123384 [Gene_View]  chr12:57522282-57607125 [Contig_View]  LRP1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000123384 [Gene_View]  chr12:57522282-57607125 [Contig_View]  LRP1 [Vega]
ICGC DataPortalENSG00000123384
TCGA cBioPortalLRP1
AceView (NCBI)LRP1
Genatlas (Paris)LRP1
WikiGenes4035
SOURCE (Princeton)LRP1
Genomic and cartography
GoldenPath hg19 (UCSC)LRP1  -     chr12:57522282-57607125 +  12q13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LRP1  -     12q13.3   [Description]    (hg38-Dec_2013)
EnsemblLRP1 - 12q13.3 [CytoView hg19]  LRP1 - 12q13.3 [CytoView hg38]
Mapping of homologs : NCBILRP1 [Mapview hg19]  LRP1 [Mapview hg38]
OMIM107770   
Gene and transcription
Genbank (Entrez)AB209498 AF370375 AK122840 BC021204 BC045107
RefSeq transcript (Entrez)NM_002332
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_016444 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)LRP1
Cluster EST : UnigeneHs.162757 [ NCBI ]
CGAP (NCI)Hs.162757
Alternative Splicing GalleryENSG00000123384
Gene ExpressionLRP1 [ NCBI-GEO ]   LRP1 [ EBI - ARRAY_EXPRESS ]   LRP1 [ SEEK ]   LRP1 [ MEM ]
Gene Expression Viewer (FireBrowse)LRP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4035
GTEX Portal (Tissue expression)LRP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07954 (Uniprot)
NextProtQ07954  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ07954
Splice isoforms : SwissVarQ07954 (Swissvar)
PhosPhoSitePlusQ07954
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    LDLRA_1 (PS01209)    LDLRA_2 (PS50068)    LDLRB (PS51120)   
Domains : Interpro (EBI)6-blade_b-propeller_TolB-like    cEGF    DUF5050    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    Growth_fac_rcpt_    LDLR_class-A_CS    LDLR_classB_rpt    LDrepeatLR_classA_rpt   
Domain families : Pfam (Sanger)cEGF (PF12662)    DUF5050 (PF16472)    EGF_CA (PF07645)    Ldl_recept_a (PF00057)    Ldl_recept_b (PF00058)   
Domain families : Pfam (NCBI)pfam12662    pfam16472    pfam07645    pfam00057    pfam00058   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  LDLa (SM00192)  LY (SM00135)  
DMDM Disease mutations4035
Blocks (Seattle)LRP1
PDB (SRS)1CR8    1D2L    1J8E    2FYJ    2FYL    2KNX    2KNY   
PDB (PDBSum)1CR8    1D2L    1J8E    2FYJ    2FYL    2KNX    2KNY   
PDB (IMB)1CR8    1D2L    1J8E    2FYJ    2FYL    2KNX    2KNY   
PDB (RSDB)1CR8    1D2L    1J8E    2FYJ    2FYL    2KNX    2KNY   
Structural Biology KnowledgeBase1CR8    1D2L    1J8E    2FYJ    2FYL    2KNX    2KNY   
SCOP (Structural Classification of Proteins)1CR8    1D2L    1J8E    2FYJ    2FYL    2KNX    2KNY   
CATH (Classification of proteins structures)1CR8    1D2L    1J8E    2FYJ    2FYL    2KNX    2KNY   
SuperfamilyQ07954
Human Protein AtlasENSG00000123384
Peptide AtlasQ07954
HPRD00138
IPIIPI00020557   IPI00435973   IPI00797187   IPI01025312   IPI00385568   IPI01025576   IPI00448904   
Protein Interaction databases
DIP (DOE-UCLA)Q07954
IntAct (EBI)Q07954
FunCoupENSG00000123384
BioGRIDLRP1
STRING (EMBL)LRP1
ZODIACLRP1
Ontologies - Pathways
QuickGOQ07954
Ontology : AmiGOretinoid metabolic process  protease binding  receptor activity  low-density lipoprotein receptor activity  calcium ion binding  protein binding  nucleolus  cytoplasm  lysosomal membrane  endosome  plasma membrane  integral component of plasma membrane  coated pit  focal adhesion  receptor-mediated endocytosis  protein kinase C-activating G-protein coupled receptor signaling pathway  aging  cell proliferation  positive regulation of cholesterol efflux  negative regulation of neuron projection development  negative regulation of smooth muscle cell migration  cerebral cortex development  clathrin-coated vesicle  negative regulation of Wnt signaling pathway  dendrite  endocytic vesicle membrane  positive regulation of lipid transport  regulation of cholesterol transport  protein complex binding  regulation of phospholipase A2 activity  regulation of actin cytoskeleton organization  apolipoprotein binding  apolipoprotein binding  aorta morphogenesis  lipoprotein metabolic process  lipoprotein transport  lipoprotein transporter activity  neuronal cell body  receptor complex  apoptotic cell clearance  negative regulation of neuron apoptotic process  poly(A) RNA binding  positive regulation of protein transport  lipoprotein particle receptor binding  beta-amyloid clearance  negative regulation of platelet-derived growth factor receptor-beta signaling pathway  
Ontology : EGO-EBIretinoid metabolic process  protease binding  receptor activity  low-density lipoprotein receptor activity  calcium ion binding  protein binding  nucleolus  cytoplasm  lysosomal membrane  endosome  plasma membrane  integral component of plasma membrane  coated pit  focal adhesion  receptor-mediated endocytosis  protein kinase C-activating G-protein coupled receptor signaling pathway  aging  cell proliferation  positive regulation of cholesterol efflux  negative regulation of neuron projection development  negative regulation of smooth muscle cell migration  cerebral cortex development  clathrin-coated vesicle  negative regulation of Wnt signaling pathway  dendrite  endocytic vesicle membrane  positive regulation of lipid transport  regulation of cholesterol transport  protein complex binding  regulation of phospholipase A2 activity  regulation of actin cytoskeleton organization  apolipoprotein binding  apolipoprotein binding  aorta morphogenesis  lipoprotein metabolic process  lipoprotein transport  lipoprotein transporter activity  neuronal cell body  receptor complex  apoptotic cell clearance  negative regulation of neuron apoptotic process  poly(A) RNA binding  positive regulation of protein transport  lipoprotein particle receptor binding  beta-amyloid clearance  negative regulation of platelet-derived growth factor receptor-beta signaling pathway  
Pathways : KEGGAlzheimer's disease    Malaria   
NDEx Network
Atlas of Cancer Signalling NetworkLRP1
Wikipedia pathwaysLRP1
Orthology - Evolution
OrthoDB4035
GeneTree (enSembl)ENSG00000123384
Phylogenetic Trees/Animal Genes : TreeFamLRP1
Homologs : HomoloGeneLRP1
Homology/Alignments : Family Browser (UCSC)LRP1
Gene fusions - Rearrangements
Fusion: TCGALRP1 12q13.3 TMEM194A SKCM
Fusion: TCGALRP1 12q13.3 XPO5 6p21.1 GBM
Polymorphisms : SNP, variants
NCBI Variation ViewerLRP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRP1
dbVarLRP1
ClinVarLRP1
1000_GenomesLRP1 
Exome Variant ServerLRP1
ExAC (Exome Aggregation Consortium)LRP1 (select the gene name)
Genetic variants : HAPMAP4035
Genomic Variants (DGV)LRP1 [DGVbeta]
Mutations
ICGC Data PortalLRP1 
TCGA Data PortalLRP1 
Broad Tumor PortalLRP1
OASIS PortalLRP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRP1 
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LRP1
DgiDB (Drug Gene Interaction Database)LRP1
DoCM (Curated mutations)LRP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRP1 (select a term)
intoGenLRP1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:57522282-57607125  ENSG00000123384
CONAN: Copy Number AnalysisLRP1 
Mutations and Diseases : HGMDLRP1
OMIM107770   
MedgenLRP1
Genetic Testing Registry LRP1
NextProtQ07954 [Medical]
TSGene4035
GENETestsLRP1
Huge Navigator LRP1 [HugePedia]
snp3D : Map Gene to Disease4035
BioCentury BCIQLRP1
ClinGenLRP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4035
Chemical/Pharm GKB GenePA233
Clinical trialLRP1
Miscellaneous
canSAR (ICR)LRP1 (select the gene name)
Probes
Litterature
PubMed356 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRP1
EVEXLRP1
GoPubMedLRP1
iHOPLRP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat May 28 11:09:31 CEST 2016

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