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LRP11 (LDL receptor related protein 11)

Identity

Alias (NCBI)MANSC3
bA350J20.3
HGNC (Hugo) LRP11
HGNC Alias symbbA350J20.3
MANSC3
HGNC Previous namelow density lipoprotein receptor-related protein 11
LocusID (NCBI) 84918
Atlas_Id 68587
Location 6q25.1  [Link to chromosome band 6q25]
Location_base_pair Starts at 149818758 and ends at 149864344 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DHCR24 (1p32.3) / LRP11 (6q25.1)LRP11 (6q25.1) / FSD1 (19p13.3)LRP11 (6q25.1) / MTMR11 (1q21.2)
LRP11 (6q25.1) / ULBP2 (6q25.1)SMARCD3 (7q36.1) / LRP11 (6q25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;6)(p32;q25) DHCR24/LRP11
LRP11/ULBP2 (6q25)


External links

Nomenclature
HGNC (Hugo)LRP11   16936
Cards
Entrez_Gene (NCBI)LRP11  84918  LDL receptor related protein 11
AliasesMANSC3; bA350J20.3
GeneCards (Weizmann)LRP11
Ensembl hg19 (Hinxton)ENSG00000120256 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120256 [Gene_View]  ENSG00000120256 [Sequence]  chr6:149818758-149864344 [Contig_View]  LRP11 [Vega]
ICGC DataPortalENSG00000120256
TCGA cBioPortalLRP11
AceView (NCBI)LRP11
Genatlas (Paris)LRP11
WikiGenes84918
SOURCE (Princeton)LRP11
Genetics Home Reference (NIH)LRP11
Genomic and cartography
GoldenPath hg38 (UCSC)LRP11  -     chr6:149818758-149864344 -  6q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LRP11  -     6q25.1   [Description]    (hg19-Feb_2009)
GoldenPathLRP11 - 6q25.1 [CytoView hg19]  LRP11 - 6q25.1 [CytoView hg38]
ImmunoBaseENSG00000120256
genome Data Viewer NCBILRP11 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AK027641 AK223134 AK299599 BC025239 BC043141
RefSeq transcript (Entrez)NM_032832
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LRP11
Alternative Splicing GalleryENSG00000120256
Gene ExpressionLRP11 [ NCBI-GEO ]   LRP11 [ EBI - ARRAY_EXPRESS ]   LRP11 [ SEEK ]   LRP11 [ MEM ]
Gene Expression Viewer (FireBrowse)LRP11 [ Firebrowse - Broad ]
GenevisibleExpression of LRP11 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84918
GTEX Portal (Tissue expression)LRP11
Human Protein AtlasENSG00000120256-LRP11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86VZ4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86VZ4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86VZ4
Splice isoforms : SwissVarQ86VZ4
PhosPhoSitePlusQ86VZ4
Domaine pattern : Prosite (Expaxy)LDLRA_1 (PS01209)    LDLRA_2 (PS50068)    MANSC (PS50986)    PKD (PS50093)   
Domains : Interpro (EBI)Ig-like_fold    LDL_receptor-like_sf    LDLR_class-A_CS    LDrepeatLR_classA_rpt    LRP11    MANSC_dom    MANSC_N    PKD/Chitinase_dom    PKD_dom    PKD_dom_sf   
Domain families : Pfam (Sanger)Ldl_recept_a (PF00057)    MANEC (PF07502)   
Domain families : Pfam (NCBI)pfam00057    pfam07502   
Domain families : Smart (EMBL)LDLa (SM00192)  MANEC (SM00765)  PKD (SM00089)  
Conserved Domain (NCBI)LRP11
DMDM Disease mutations84918
Blocks (Seattle)LRP11
SuperfamilyQ86VZ4
Human Protein Atlas [tissue]ENSG00000120256-LRP11 [tissue]
Peptide AtlasQ86VZ4
HPRD17446
IPIIPI00045841   IPI00739809   IPI01016038   IPI00477270   
Protein Interaction databases
DIP (DOE-UCLA)Q86VZ4
IntAct (EBI)Q86VZ4
FunCoupENSG00000120256
BioGRIDLRP11
STRING (EMBL)LRP11
ZODIACLRP11
Ontologies - Pathways
QuickGOQ86VZ4
Ontology : AmiGOplasma membrane  response to heat  response to cold  response to water deprivation  response to mechanical stimulus  integral component of membrane  multicellular organismal response to stress  response to immobilization stress  response to starvation  phosphoprotein binding  
Ontology : EGO-EBIplasma membrane  response to heat  response to cold  response to water deprivation  response to mechanical stimulus  integral component of membrane  multicellular organismal response to stress  response to immobilization stress  response to starvation  phosphoprotein binding  
NDEx NetworkLRP11
Atlas of Cancer Signalling NetworkLRP11
Wikipedia pathwaysLRP11
Orthology - Evolution
OrthoDB84918
GeneTree (enSembl)ENSG00000120256
Phylogenetic Trees/Animal Genes : TreeFamLRP11
HOGENOMQ86VZ4
Homologs : HomoloGeneLRP11
Homology/Alignments : Family Browser (UCSC)LRP11
Gene fusions - Rearrangements
Fusion : QuiverLRP11
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRP11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRP11
dbVarLRP11
ClinVarLRP11
1000_GenomesLRP11 
Exome Variant ServerLRP11
GNOMAD BrowserENSG00000120256
Varsome BrowserLRP11
Genetic variants : HAPMAP84918
Genomic Variants (DGV)LRP11 [DGVbeta]
DECIPHERLRP11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLRP11 
Mutations
ICGC Data PortalLRP11 
TCGA Data PortalLRP11 
Broad Tumor PortalLRP11
OASIS PortalLRP11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRP11  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLRP11
Mutations and Diseases : HGMDLRP11
BioMutasearch LRP11
DgiDB (Drug Gene Interaction Database)LRP11
DoCM (Curated mutations)LRP11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRP11 (select a term)
intoGenLRP11
Cancer3DLRP11(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETLRP11
MedgenLRP11
Genetic Testing Registry LRP11
NextProtQ86VZ4 [Medical]
TSGene84918
GENETestsLRP11
Target ValidationLRP11
Huge Navigator LRP11 [HugePedia]
snp3D : Map Gene to Disease84918
BioCentury BCIQLRP11
ClinGenLRP11
Clinical trials, drugs, therapy
Protein Interactions : CTD84918
Pharm GKB GenePA134880462
Clinical trialLRP11
Miscellaneous
canSAR (ICR)LRP11 (select the gene name)
HarmonizomeLRP11
DataMed IndexLRP11
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRP11
EVEXLRP11
GoPubMedLRP11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Aug 22 19:23:59 CEST 2020

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