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LRP12 (LDL receptor related protein 12)

Identity

Alias_nameslow density lipoprotein receptor-related protein 12
Alias_symbol (synonym)ST7
FLJ12929
Other alias
HGNC (Hugo) LRP12
LocusID (NCBI) 29967
Atlas_Id 42424
Location 8q22.3  [Link to chromosome band 8q22]
Location_base_pair Starts at 105501459 and ends at 105601252 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATAD2 (8q24.13) / LRP12 (8q22.3)LRP12 (8q22.3) / KCNB2 (8q13.3)LRP12 (8q22.3) / LAPTM4B (8q22.1)
LRP12 (8q22.3) / RIMS2 (8q22.3)LRP12 (8q22.3) / TRAPPC9 (8q24.3)LRP12 (8q22.3) / VPS13B (8q22.2)
TRPS1 (8q23.3) / LRP12 (8q22.3)ATAD2 8q24.13 / LRP12 8q22.3LRP12 8q22.3 / KCNB2 8q13.3
LRP12 8q22.3 / LAPTM4B 8q22.1LRP12 8q22.3 / RIMS2 8q22.3LRP12 8q22.3 / TRAPPC9 8q24.3
LRP12 8q22.3 / VPS13B 8q22.2TRPS1 8q23.3 / LRP12 8q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LRP12   31708
Cards
Entrez_Gene (NCBI)LRP12  29967  LDL receptor related protein 12
AliasesST7
GeneCards (Weizmann)LRP12
Ensembl hg19 (Hinxton)ENSG00000147650 [Gene_View]  chr8:105501459-105601252 [Contig_View]  LRP12 [Vega]
Ensembl hg38 (Hinxton)ENSG00000147650 [Gene_View]  chr8:105501459-105601252 [Contig_View]  LRP12 [Vega]
ICGC DataPortalENSG00000147650
TCGA cBioPortalLRP12
AceView (NCBI)LRP12
Genatlas (Paris)LRP12
WikiGenes29967
SOURCE (Princeton)LRP12
Genetics Home Reference (NIH)LRP12
Genomic and cartography
GoldenPath hg19 (UCSC)LRP12  -     chr8:105501459-105601252 -  8q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LRP12  -     8q22.3   [Description]    (hg38-Dec_2013)
EnsemblLRP12 - 8q22.3 [CytoView hg19]  LRP12 - 8q22.3 [CytoView hg38]
Mapping of homologs : NCBILRP12 [Mapview hg19]  LRP12 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB208957 AF064841 AF166350 AI828757 AK022991
RefSeq transcript (Entrez)NM_001135703 NM_013437
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_008046 NW_004929340
Consensus coding sequences : CCDS (NCBI)LRP12
Cluster EST : UnigeneHs.715867 [ NCBI ]
CGAP (NCI)Hs.715867
Alternative Splicing GalleryENSG00000147650
Gene ExpressionLRP12 [ NCBI-GEO ]   LRP12 [ EBI - ARRAY_EXPRESS ]   LRP12 [ SEEK ]   LRP12 [ MEM ]
Gene Expression Viewer (FireBrowse)LRP12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29967
GTEX Portal (Tissue expression)LRP12
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y561   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y561  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y561
Splice isoforms : SwissVarQ9Y561
PhosPhoSitePlusQ9Y561
Domaine pattern : Prosite (Expaxy)CUB (PS01180)    LDLRA_1 (PS01209)    LDLRA_2 (PS50068)   
Domains : Interpro (EBI)CUB_dom    LDLR_class-A_CS    LDrepeatLR_classA_rpt   
Domain families : Pfam (Sanger)CUB (PF00431)    Ldl_recept_a (PF00057)   
Domain families : Pfam (NCBI)pfam00431    pfam00057   
Domain families : Smart (EMBL)CUB (SM00042)  LDLa (SM00192)  
Conserved Domain (NCBI)LRP12
DMDM Disease mutations29967
Blocks (Seattle)LRP12
SuperfamilyQ9Y561
Human Protein AtlasENSG00000147650
Peptide AtlasQ9Y561
HPRD17447
IPIIPI00021027   IPI00914038   IPI00979660   IPI00982632   IPI00974398   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y561
IntAct (EBI)Q9Y561
FunCoupENSG00000147650
BioGRIDLRP12
STRING (EMBL)LRP12
ZODIACLRP12
Ontologies - Pathways
QuickGOQ9Y561
Ontology : AmiGOlow-density lipoprotein receptor activity  protein binding  integral component of plasma membrane  coated pit  endocytosis  receptor-mediated endocytosis  signal transduction  integral component of membrane  regulation of growth  
Ontology : EGO-EBIlow-density lipoprotein receptor activity  protein binding  integral component of plasma membrane  coated pit  endocytosis  receptor-mediated endocytosis  signal transduction  integral component of membrane  regulation of growth  
NDEx NetworkLRP12
Atlas of Cancer Signalling NetworkLRP12
Wikipedia pathwaysLRP12
Orthology - Evolution
OrthoDB29967
GeneTree (enSembl)ENSG00000147650
Phylogenetic Trees/Animal Genes : TreeFamLRP12
HOVERGENQ9Y561
HOGENOMQ9Y561
Homologs : HomoloGeneLRP12
Homology/Alignments : Family Browser (UCSC)LRP12
Gene fusions - Rearrangements
Fusion : MitelmanATAD2/LRP12 [8q24.13/8q22.3]  [t(8;8)(q22;q24)]  
Fusion : MitelmanLRP12/KCNB2 [8q22.3/8q13.3]  [t(8;8)(q13;q22)]  
Fusion : MitelmanLRP12/LAPTM4B [8q22.3/8q22.1]  [t(8;8)(q22;q22)]  
Fusion : MitelmanLRP12/RIMS2 [8q22.3/8q22.3]  [t(8;8)(q22;q22)]  
Fusion : MitelmanLRP12/TRAPPC9 [8q22.3/8q24.3]  [t(8;8)(q22;q24)]  
Fusion : MitelmanLRP12/VPS13B [8q22.3/8q22.2]  [t(8;8)(q22;q22)]  
Fusion : MitelmanTRPS1/LRP12 [8q23.3/8q22.3]  [t(8;8)(q22;q23)]  
Fusion: TCGAATAD2 8q24.13 LRP12 8q22.3 LUAD
Fusion: TCGALRP12 8q22.3 KCNB2 8q13.3 BRCA
Fusion: TCGALRP12 8q22.3 LAPTM4B 8q22.1 BRCA
Fusion: TCGALRP12 8q22.3 RIMS2 8q22.3 BRCA
Fusion: TCGALRP12 8q22.3 TRAPPC9 8q24.3 BRCA
Fusion: TCGALRP12 8q22.3 VPS13B 8q22.2 BRCA
Fusion: TCGATRPS1 8q23.3 LRP12 8q22.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRP12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRP12
dbVarLRP12
ClinVarLRP12
1000_GenomesLRP12 
Exome Variant ServerLRP12
ExAC (Exome Aggregation Consortium)LRP12 (select the gene name)
Genetic variants : HAPMAP29967
Genomic Variants (DGV)LRP12 [DGVbeta]
DECIPHER (Syndromes)8:105501459-105601252  ENSG00000147650
CONAN: Copy Number AnalysisLRP12 
Mutations
ICGC Data PortalLRP12 
TCGA Data PortalLRP12 
Broad Tumor PortalLRP12
OASIS PortalLRP12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRP12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLRP12
BioMutasearch LRP12
DgiDB (Drug Gene Interaction Database)LRP12
DoCM (Curated mutations)LRP12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRP12 (select a term)
intoGenLRP12
Cancer3DLRP12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenLRP12
Genetic Testing Registry LRP12
NextProtQ9Y561 [Medical]
TSGene29967
GENETestsLRP12
Huge Navigator LRP12 [HugePedia]
snp3D : Map Gene to Disease29967
BioCentury BCIQLRP12
ClinGenLRP12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29967
Chemical/Pharm GKB GenePA134921850
Clinical trialLRP12
Miscellaneous
canSAR (ICR)LRP12 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRP12
EVEXLRP12
GoPubMedLRP12
iHOPLRP12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:13:45 CET 2017

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