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LRP2 (low density lipoprotein receptor-related protein 2)

Identity

Other namesDBS
GP330
HGNC (Hugo) LRP2
LocusID (NCBI) 4036
Location 2q31.1
Location_base_pair Starts at 169983619 and ends at 170219122 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LRP2   6694
Cards
Entrez_Gene (NCBI)LRP2  4036  low density lipoprotein receptor-related protein 2
GeneCards (Weizmann)LRP2
Ensembl (Hinxton)ENSG00000081479 [Gene_View]  chr2:169983619-170219122 [Contig_View]  LRP2 [Vega]
ICGC DataPortalENSG00000081479
cBioPortalLRP2
AceView (NCBI)LRP2
Genatlas (Paris)LRP2
WikiGenes4036
SOURCE (Princeton)NM_004525
Genomic and cartography
GoldenPath (UCSC)LRP2  -  2q31.1   chr2:169983619-170219122 -  2q31.1   [Description]    (hg19-Feb_2009)
EnsemblLRP2 - 2q31.1 [CytoView]
Mapping of homologs : NCBILRP2 [Mapview]
OMIM222448   600073   
Gene and transcription
Genbank (Entrez)AK295005 AK302843 AY265357 AY265358 CD673312
RefSeq transcript (Entrez)NM_004525
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_012634 NT_005403 NW_001838860 NW_004929305
Consensus coding sequences : CCDS (NCBI)LRP2
Cluster EST : UnigeneHs.657729 [ NCBI ]
CGAP (NCI)Hs.657729
Alternative Splicing : Fast-db (Paris)GSHG0018134
Alternative Splicing GalleryENSG00000081479
Gene ExpressionLRP2 [ NCBI-GEO ]     LRP2 [ SEEK ]   LRP2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP98164 (Uniprot)
NextProtP98164  [Medical]
With graphics : InterProP98164
Splice isoforms : SwissVarP98164 (Swissvar)
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    LDLRA_1 (PS01209)    LDLRA_2 (PS50068)    LDLRB (PS51120)   
Domains : Interpro (EBI)6-blade_b-propeller_TolB-like [organisation]   cEGF [organisation]   EG-like_dom [organisation]   EGF-like_Ca-bd_dom [organisation]   EGF-like_CS [organisation]   EGF-type_Asp/Asn_hydroxyl_site [organisation]   EGF_Ca-bd_CS [organisation]   Growth_fac_rcpt_N_dom [organisation]   LDLR_class-A_CS [organisation]   LDLR_classB_rpt [organisation]   LDrepeatLR_classA_rpt [organisation]   Lectin_legB_Mn/Ca_BS [organisation]  
Related proteins : CluSTrP98164
Domain families : Pfam (Sanger)cEGF (PF12662)    EGF_CA (PF07645)    Ldl_recept_a (PF00057)    Ldl_recept_b (PF00058)   
Domain families : Pfam (NCBI)pfam12662    pfam07645    pfam00057    pfam00058   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  LDLa (SM00192)  LY (SM00135)  
DMDM Disease mutations4036
Blocks (Seattle)P98164
PDB (SRS)2M0P   
PDB (PDBSum)2M0P   
PDB (IMB)2M0P   
PDB (RSDB)2M0P   
Human Protein AtlasENSG00000081479 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP98164
HPRD02509
IPIIPI00024292   IPI00909411   IPI00924951   
Protein Interaction databases
DIP (DOE-UCLA)P98164
IntAct (EBI)P98164
FunCoupENSG00000081479
BioGRIDLRP2
InParanoidP98164
Interologous Interaction database P98164
IntegromeDBLRP2
STRING (EMBL)LRP2
Ontologies - Pathways
Ontology : AmiGOretinoid metabolic process  calcium ion binding  protein binding  lysosome  lysosomal membrane  endosome  endoplasmic reticulum  Golgi apparatus  plasma membrane  coated pit  protein glycosylation  lipid metabolic process  endocytosis  receptor-mediated endocytosis  phototransduction, visible light  steroid metabolic process  cell proliferation  integral component of membrane  apical plasma membrane  SH3 domain binding  endocytic vesicle  forebrain development  brush border membrane  vitamin D metabolic process  receptor complex  small molecule metabolic process  extracellular vesicular exosome  
Ontology : EGO-EBIretinoid metabolic process  calcium ion binding  protein binding  lysosome  lysosomal membrane  endosome  endoplasmic reticulum  Golgi apparatus  plasma membrane  coated pit  protein glycosylation  lipid metabolic process  endocytosis  receptor-mediated endocytosis  phototransduction, visible light  steroid metabolic process  cell proliferation  integral component of membrane  apical plasma membrane  SH3 domain binding  endocytic vesicle  forebrain development  brush border membrane  vitamin D metabolic process  receptor complex  small molecule metabolic process  extracellular vesicular exosome  
Pathways : KEGGHedgehog signaling pathway    Thyroid hormone synthesis   
Protein Interaction DatabaseLRP2
Wikipedia pathwaysLRP2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)LRP2
snp3D : Map Gene to Disease4036
SNP (GeneSNP Utah)LRP2
SNP : HGBaseLRP2
Genetic variants : HAPMAPLRP2
Exome VariantLRP2
1000_GenomesLRP2 
ICGC programENSG00000081479 
Somatic Mutations in Cancer : COSMICLRP2 
CONAN: Copy Number AnalysisLRP2 
Mutations and Diseases : HGMDLRP2
Mutations and Diseases : intOGenLRP2
Genomic VariantsLRP2  LRP2 [DGVbeta]
dbVarLRP2
ClinVarLRP2
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM222448    600073   
MedgenLRP2
GENETestsLRP2
Disease Genetic AssociationLRP2
Huge Navigator LRP2 [HugePedia]  LRP2 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneLRP2
Homology/Alignments : Family Browser (UCSC)LRP2
Phylogenetic Trees/Animal Genes : TreeFamLRP2
Chemical/Protein Interactions : CTD4036
Chemical/Pharm GKB GenePA30452
Clinical trialLRP2
Cancer Resource (Charite)ENSG00000081479
Other databases
Probes
Litterature
PubMed101 Pubmed reference(s) in Entrez
CoreMineLRP2
iHOPLRP2
OncoSearchLRP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 22 19:00:42 CEST 2014

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