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LRP4 (LDL receptor related protein 4)

Identity

Alias_nameslow density lipoprotein receptor-related protein 4
Alias_symbol (synonym)MEGF7
CLSS
LRP-4
SOST2
Other aliasCMS17
LRP10
HGNC (Hugo) LRP4
LocusID (NCBI) 4038
Atlas_Id 68589
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 46856717 and ends at 46918622 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LRP4 (11p11.2) / C14orf37 (14q23.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LRP4   6696
Cards
Entrez_Gene (NCBI)LRP4  4038  LDL receptor related protein 4
AliasesCLSS; CMS17; LRP-4; LRP10; 
MEGF7; SOST2
GeneCards (Weizmann)LRP4
Ensembl hg19 (Hinxton)ENSG00000134569 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134569 [Gene_View]  chr11:46856717-46918622 [Contig_View]  LRP4 [Vega]
ICGC DataPortalENSG00000134569
TCGA cBioPortalLRP4
AceView (NCBI)LRP4
Genatlas (Paris)LRP4
WikiGenes4038
SOURCE (Princeton)LRP4
Genetics Home Reference (NIH)LRP4
Genomic and cartography
GoldenPath hg38 (UCSC)LRP4  -     chr11:46856717-46918622 -  11p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LRP4  -     11p11.2   [Description]    (hg19-Feb_2009)
EnsemblLRP4 - 11p11.2 [CytoView hg19]  LRP4 - 11p11.2 [CytoView hg38]
Mapping of homologs : NCBILRP4 [Mapview hg19]  LRP4 [Mapview hg38]
OMIM212780   604270   614305   616304   
Gene and transcription
Genbank (Entrez)AB011540 AB084910 AB231861 AK027175 BC037360
RefSeq transcript (Entrez)NM_002334
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LRP4
Cluster EST : UnigeneHs.4930 [ NCBI ]
CGAP (NCI)Hs.4930
Alternative Splicing GalleryENSG00000134569
Gene ExpressionLRP4 [ NCBI-GEO ]   LRP4 [ EBI - ARRAY_EXPRESS ]   LRP4 [ SEEK ]   LRP4 [ MEM ]
Gene Expression Viewer (FireBrowse)LRP4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4038
GTEX Portal (Tissue expression)LRP4
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75096   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75096  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75096
Splice isoforms : SwissVarO75096
PhosPhoSitePlusO75096
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_2 (PS01186)    EGF_CA (PS01187)    LDLRA_1 (PS01209)    LDLRA_2 (PS50068)    LDLRB (PS51120)   
Domains : Interpro (EBI)6-blade_b-propeller_TolB-like    cEGF    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    Growth_fac_rcpt_    LDLR_class-A_CS    LDLR_classB_rpt    LDrepeatLR_classA_rpt    LRP4   
Domain families : Pfam (Sanger)cEGF (PF12662)    Ldl_recept_a (PF00057)    Ldl_recept_b (PF00058)   
Domain families : Pfam (NCBI)pfam12662    pfam00057    pfam00058   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  LDLa (SM00192)  LY (SM00135)  
Conserved Domain (NCBI)LRP4
DMDM Disease mutations4038
Blocks (Seattle)LRP4
SuperfamilyO75096
Human Protein AtlasENSG00000134569
Peptide AtlasO75096
HPRD18517
IPIIPI00930747   IPI00977258   
Protein Interaction databases
DIP (DOE-UCLA)O75096
IntAct (EBI)O75096
FunCoupENSG00000134569
BioGRIDLRP4
STRING (EMBL)LRP4
ZODIACLRP4
Ontologies - Pathways
QuickGOO75096
Ontology : AmiGOkidney development  hair follicle development  calcium ion binding  protein binding  plasma membrane  endocytosis  proximal/distal pattern formation  cell surface  cell surface  postsynaptic density  integral component of membrane  flotillin complex  Wnt-protein binding  negative regulation of ossification  dendrite  BMP signaling pathway  receptor tyrosine kinase binding  neuromuscular junction  apolipoprotein binding  odontogenesis of dentin-containing tooth  embryonic digit morphogenesis  protein homodimerization activity  Wnt-activated receptor activity  neuronal cell body  receptor complex  Wnt signaling pathway involved in dorsal/ventral axis specification  dendrite morphogenesis  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of axonogenesis  synapse organization  synaptic growth at neuromuscular junction  protein heterotetramerization  limb development  skeletal muscle acetylcholine-gated channel clustering  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  synaptic membrane  postsynaptic membrane assembly  presynaptic membrane assembly  scaffold protein binding  positive regulation of presynaptic membrane organization  positive regulation of skeletal muscle acetylcholine-gated channel clustering  
Ontology : EGO-EBIkidney development  hair follicle development  calcium ion binding  protein binding  plasma membrane  endocytosis  proximal/distal pattern formation  cell surface  cell surface  postsynaptic density  integral component of membrane  flotillin complex  Wnt-protein binding  negative regulation of ossification  dendrite  BMP signaling pathway  receptor tyrosine kinase binding  neuromuscular junction  apolipoprotein binding  odontogenesis of dentin-containing tooth  embryonic digit morphogenesis  protein homodimerization activity  Wnt-activated receptor activity  neuronal cell body  receptor complex  Wnt signaling pathway involved in dorsal/ventral axis specification  dendrite morphogenesis  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of axonogenesis  synapse organization  synaptic growth at neuromuscular junction  protein heterotetramerization  limb development  skeletal muscle acetylcholine-gated channel clustering  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  synaptic membrane  postsynaptic membrane assembly  presynaptic membrane assembly  scaffold protein binding  positive regulation of presynaptic membrane organization  positive regulation of skeletal muscle acetylcholine-gated channel clustering  
NDEx NetworkLRP4
Atlas of Cancer Signalling NetworkLRP4
Wikipedia pathwaysLRP4
Orthology - Evolution
OrthoDB4038
GeneTree (enSembl)ENSG00000134569
Phylogenetic Trees/Animal Genes : TreeFamLRP4
HOVERGENO75096
HOGENOMO75096
Homologs : HomoloGeneLRP4
Homology/Alignments : Family Browser (UCSC)LRP4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRP4
dbVarLRP4
ClinVarLRP4
1000_GenomesLRP4 
Exome Variant ServerLRP4
ExAC (Exome Aggregation Consortium)LRP4 (select the gene name)
Genetic variants : HAPMAP4038
Genomic Variants (DGV)LRP4 [DGVbeta]
DECIPHERLRP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLRP4 
Mutations
ICGC Data PortalLRP4 
TCGA Data PortalLRP4 
Broad Tumor PortalLRP4
OASIS PortalLRP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRP4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLRP4
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch LRP4
DgiDB (Drug Gene Interaction Database)LRP4
DoCM (Curated mutations)LRP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRP4 (select a term)
intoGenLRP4
Cancer3DLRP4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM212780    604270    614305    616304   
Orphanet2819    2913    13930   
MedgenLRP4
Genetic Testing Registry LRP4
NextProtO75096 [Medical]
TSGene4038
GENETestsLRP4
Target ValidationLRP4
Huge Navigator LRP4 [HugePedia]
snp3D : Map Gene to Disease4038
BioCentury BCIQLRP4
ClinGenLRP4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4038
Chemical/Pharm GKB GenePA30454
Clinical trialLRP4
Miscellaneous
canSAR (ICR)LRP4 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRP4
EVEXLRP4
GoPubMedLRP4
iHOPLRP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:26:26 CEST 2017

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