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LRPAP1 (LDL receptor related protein associated protein 1)

Identity

Alias_namesA2MRAP
low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)
low density lipoprotein receptor-related protein associated protein 1
Alias_symbol (synonym)HBP44
Other aliasA2RAP
MRAP
MYP23
RAP
alpha-2-MRAP
HGNC (Hugo) LRPAP1
LocusID (NCBI) 4043
Atlas_Id 50604
Location 4p16.3  [Link to chromosome band 4p16]
Location_base_pair Starts at 3505324 and ends at 3534224 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LRPAP1 (4p16.3) / HNRNPM (19p13.2)LRPAP1 (4p16.3) / LRPAP1 (4p16.3)NCBP3 (17p13.2) / LRPAP1 (4p16.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LRPAP1   6701
Cards
Entrez_Gene (NCBI)LRPAP1  4043  LDL receptor related protein associated protein 1
AliasesA2MRAP; A2RAP; HBP44; MRAP; 
MYP23; RAP; alpha-2-MRAP
GeneCards (Weizmann)LRPAP1
Ensembl hg19 (Hinxton)ENSG00000163956 [Gene_View]  chr4:3505324-3534224 [Contig_View]  LRPAP1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000163956 [Gene_View]  chr4:3505324-3534224 [Contig_View]  LRPAP1 [Vega]
ICGC DataPortalENSG00000163956
TCGA cBioPortalLRPAP1
AceView (NCBI)LRPAP1
Genatlas (Paris)LRPAP1
WikiGenes4043
SOURCE (Princeton)LRPAP1
Genetics Home Reference (NIH)LRPAP1
Genomic and cartography
GoldenPath hg19 (UCSC)LRPAP1  -     chr4:3505324-3534224 -  4p16.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LRPAP1  -     4p16.3   [Description]    (hg38-Dec_2013)
EnsemblLRPAP1 - 4p16.3 [CytoView hg19]  LRPAP1 - 4p16.3 [CytoView hg38]
Mapping of homologs : NCBILRPAP1 [Mapview hg19]  LRPAP1 [Mapview hg38]
OMIM104225   615431   
Gene and transcription
Genbank (Entrez)AK222504 AK222527 AK292321 AK310598 AK310851
RefSeq transcript (Entrez)NM_002337
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_033873 NT_006051 NW_004929314
Consensus coding sequences : CCDS (NCBI)LRPAP1
Cluster EST : UnigeneHs.40966 [ NCBI ]
CGAP (NCI)Hs.40966
Alternative Splicing GalleryENSG00000163956
Gene ExpressionLRPAP1 [ NCBI-GEO ]   LRPAP1 [ EBI - ARRAY_EXPRESS ]   LRPAP1 [ SEEK ]   LRPAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)LRPAP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4043
GTEX Portal (Tissue expression)LRPAP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30533   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30533  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30533
Splice isoforms : SwissVarP30533
PhosPhoSitePlusP30533
Domaine pattern : Prosite (Expaxy)ER_TARGET (PS00014)   
Domains : Interpro (EBI)Alpha_2_MRAP_C    MG_RAP_rcpt_1   
Domain families : Pfam (Sanger)Alpha-2-MRAP_C (PF06401)    Alpha-2-MRAP_N (PF06400)   
Domain families : Pfam (NCBI)pfam06401    pfam06400   
Conserved Domain (NCBI)LRPAP1
DMDM Disease mutations4043
Blocks (Seattle)LRPAP1
PDB (SRS)1LRE    1NRE    1OP1    1OV2    2FCW    2FTU    2FYL    2P01    2P03   
PDB (PDBSum)1LRE    1NRE    1OP1    1OV2    2FCW    2FTU    2FYL    2P01    2P03   
PDB (IMB)1LRE    1NRE    1OP1    1OV2    2FCW    2FTU    2FYL    2P01    2P03   
PDB (RSDB)1LRE    1NRE    1OP1    1OV2    2FCW    2FTU    2FYL    2P01    2P03   
Structural Biology KnowledgeBase1LRE    1NRE    1OP1    1OV2    2FCW    2FTU    2FYL    2P01    2P03   
SCOP (Structural Classification of Proteins)1LRE    1NRE    1OP1    1OV2    2FCW    2FTU    2FYL    2P01    2P03   
CATH (Classification of proteins structures)1LRE    1NRE    1OP1    1OV2    2FCW    2FTU    2FYL    2P01    2P03   
SuperfamilyP30533
Human Protein AtlasENSG00000163956
Peptide AtlasP30533
HPRD00082
IPIIPI00026848   IPI00936873   IPI00966982   
Protein Interaction databases
DIP (DOE-UCLA)P30533
IntAct (EBI)P30533
FunCoupENSG00000163956
BioGRIDLRPAP1
STRING (EMBL)LRPAP1
ZODIACLRPAP1
Ontologies - Pathways
QuickGOP30533
Ontology : AmiGOasialoglycoprotein receptor activity  protein binding  extracellular region  endoplasmic reticulum  plasma membrane  protein folding  receptor-mediated endocytosis  heparin binding  cell surface  negative regulation of very-low-density lipoprotein particle clearance  integral component of membrane  vesicle-mediated transport  vesicle  negative regulation of protein binding  lipase binding  receptor antagonist activity  rough endoplasmic reticulum lumen  low-density lipoprotein particle receptor binding  unfolded protein binding  very-low-density lipoprotein particle receptor binding  extracellular negative regulation of signal transduction  negative regulation of beta-amyloid clearance  
Ontology : EGO-EBIasialoglycoprotein receptor activity  protein binding  extracellular region  endoplasmic reticulum  plasma membrane  protein folding  receptor-mediated endocytosis  heparin binding  cell surface  negative regulation of very-low-density lipoprotein particle clearance  integral component of membrane  vesicle-mediated transport  vesicle  negative regulation of protein binding  lipase binding  receptor antagonist activity  rough endoplasmic reticulum lumen  low-density lipoprotein particle receptor binding  unfolded protein binding  very-low-density lipoprotein particle receptor binding  extracellular negative regulation of signal transduction  negative regulation of beta-amyloid clearance  
NDEx NetworkLRPAP1
Atlas of Cancer Signalling NetworkLRPAP1
Wikipedia pathwaysLRPAP1
Orthology - Evolution
OrthoDB4043
GeneTree (enSembl)ENSG00000163956
Phylogenetic Trees/Animal Genes : TreeFamLRPAP1
HOVERGENP30533
HOGENOMP30533
Homologs : HomoloGeneLRPAP1
Homology/Alignments : Family Browser (UCSC)LRPAP1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRPAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRPAP1
dbVarLRPAP1
ClinVarLRPAP1
1000_GenomesLRPAP1 
Exome Variant ServerLRPAP1
ExAC (Exome Aggregation Consortium)LRPAP1 (select the gene name)
Genetic variants : HAPMAP4043
Genomic Variants (DGV)LRPAP1 [DGVbeta]
DECIPHER (Syndromes)4:3505324-3534224  ENSG00000163956
CONAN: Copy Number AnalysisLRPAP1 
Mutations
ICGC Data PortalLRPAP1 
TCGA Data PortalLRPAP1 
Broad Tumor PortalLRPAP1
OASIS PortalLRPAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRPAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLRPAP1
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch LRPAP1
DgiDB (Drug Gene Interaction Database)LRPAP1
DoCM (Curated mutations)LRPAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRPAP1 (select a term)
intoGenLRPAP1
Cancer3DLRPAP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM104225    615431   
Orphanet13636   
MedgenLRPAP1
Genetic Testing Registry LRPAP1
NextProtP30533 [Medical]
TSGene4043
GENETestsLRPAP1
Huge Navigator LRPAP1 [HugePedia]
snp3D : Map Gene to Disease4043
BioCentury BCIQLRPAP1
ClinGenLRPAP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4043
Chemical/Pharm GKB GenePA30458
Clinical trialLRPAP1
Miscellaneous
canSAR (ICR)LRPAP1 (select the gene name)
Probes
Litterature
PubMed95 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRPAP1
EVEXLRPAP1
GoPubMedLRPAP1
iHOPLRPAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:13:46 CET 2017

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