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LRRC27 (leucine rich repeat containing 27)

Identity

Alias_symbol (synonym)KIAA1674
Other alias-
HGNC (Hugo) LRRC27
LocusID (NCBI) 80313
Atlas_Id 68604
Location 10q26.3  [Link to chromosome band 10q26]
Location_base_pair Starts at 132332237 and ends at 132381506 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HIST1H2BD (6p22.2) / LRRC27 (10q26.3)LRRC27 (10q26.3) / MAGI1 (3p14.1)RPAIN (17p13.2) / LRRC27 (10q26.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;17)(q26;p13) RPAIN/LRRC27

External links

Nomenclature
HGNC (Hugo)LRRC27   29346
Cards
Entrez_Gene (NCBI)LRRC27  80313  leucine rich repeat containing 27
Aliases
GeneCards (Weizmann)LRRC27
Ensembl hg19 (Hinxton)ENSG00000148814 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148814 [Gene_View]  ENSG00000148814 [Sequence]  chr10:132332237-132381506 [Contig_View]  LRRC27 [Vega]
ICGC DataPortalENSG00000148814
TCGA cBioPortalLRRC27
AceView (NCBI)LRRC27
Genatlas (Paris)LRRC27
WikiGenes80313
SOURCE (Princeton)LRRC27
Genetics Home Reference (NIH)LRRC27
Genomic and cartography
GoldenPath hg38 (UCSC)LRRC27  -     chr10:132332237-132381506 +  10q26.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LRRC27  -     10q26.3   [Description]    (hg19-Feb_2009)
EnsemblLRRC27 - 10q26.3 [CytoView hg19]  LRRC27 - 10q26.3 [CytoView hg38]
Mapping of homologs : NCBILRRC27 [Mapview hg19]  LRRC27 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB051461 AK091472 AK093250 AK097418 AK098652
RefSeq transcript (Entrez)NM_001143757 NM_001143758 NM_001143759 NM_001309474 NM_030626
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LRRC27
Cluster EST : UnigeneHs.119897 [ NCBI ]
CGAP (NCI)Hs.119897
Alternative Splicing GalleryENSG00000148814
Gene ExpressionLRRC27 [ NCBI-GEO ]   LRRC27 [ EBI - ARRAY_EXPRESS ]   LRRC27 [ SEEK ]   LRRC27 [ MEM ]
Gene Expression Viewer (FireBrowse)LRRC27 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80313
GTEX Portal (Tissue expression)LRRC27
Human Protein AtlasENSG00000148814-LRRC27 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9C0I9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9C0I9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9C0I9
Splice isoforms : SwissVarQ9C0I9
PhosPhoSitePlusQ9C0I9
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp   
Domain families : Pfam (Sanger)LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam13855   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  
Conserved Domain (NCBI)LRRC27
DMDM Disease mutations80313
Blocks (Seattle)LRRC27
SuperfamilyQ9C0I9
Human Protein Atlas [tissue]ENSG00000148814-LRRC27 [tissue]
Peptide AtlasQ9C0I9
HPRD17451
IPIIPI00646883   IPI00028501   IPI00297690   IPI00384591   IPI00910663   IPI00908830   IPI00514839   
Protein Interaction databases
DIP (DOE-UCLA)Q9C0I9
IntAct (EBI)Q9C0I9
FunCoupENSG00000148814
BioGRIDLRRC27
STRING (EMBL)LRRC27
ZODIACLRRC27
Ontologies - Pathways
QuickGOQ9C0I9
Ontology : AmiGOplasma membrane  signal transduction  
Ontology : EGO-EBIplasma membrane  signal transduction  
NDEx NetworkLRRC27
Atlas of Cancer Signalling NetworkLRRC27
Wikipedia pathwaysLRRC27
Orthology - Evolution
OrthoDB80313
GeneTree (enSembl)ENSG00000148814
Phylogenetic Trees/Animal Genes : TreeFamLRRC27
HOVERGENQ9C0I9
HOGENOMQ9C0I9
Homologs : HomoloGeneLRRC27
Homology/Alignments : Family Browser (UCSC)LRRC27
Gene fusions - Rearrangements
Fusion : QuiverLRRC27
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRRC27 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRRC27
dbVarLRRC27
ClinVarLRRC27
1000_GenomesLRRC27 
Exome Variant ServerLRRC27
ExAC (Exome Aggregation Consortium)ENSG00000148814
GNOMAD BrowserENSG00000148814
Varsome BrowserLRRC27
Genetic variants : HAPMAP80313
Genomic Variants (DGV)LRRC27 [DGVbeta]
DECIPHERLRRC27 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLRRC27 
Mutations
ICGC Data PortalLRRC27 
TCGA Data PortalLRRC27 
Broad Tumor PortalLRRC27
OASIS PortalLRRC27 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRRC27  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLRRC27
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch LRRC27
DgiDB (Drug Gene Interaction Database)LRRC27
DoCM (Curated mutations)LRRC27 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRRC27 (select a term)
intoGenLRRC27
Cancer3DLRRC27(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETLRRC27
MedgenLRRC27
Genetic Testing Registry LRRC27
NextProtQ9C0I9 [Medical]
TSGene80313
GENETestsLRRC27
Target ValidationLRRC27
Huge Navigator LRRC27 [HugePedia]
snp3D : Map Gene to Disease80313
BioCentury BCIQLRRC27
ClinGenLRRC27
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80313
Chemical/Pharm GKB GenePA134904045
Clinical trialLRRC27
Miscellaneous
canSAR (ICR)LRRC27 (select the gene name)
Probes
Litterature
PubMed6 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRRC27
EVEXLRRC27
GoPubMedLRRC27
iHOPLRRC27
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 14:11:40 CEST 2018
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