LRRC32 (leucine rich repeat containing 32)

2016-08-01  

Identity

HGNC
LRRC32
LOCATION
11q13.5
LOCUSID
2615
ALIAS
CPPRDD,D11S833E,GARP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2615
MIM: 137207
HGNC: 4161
Ensembl: ENSG00000137507

Variants:

dbSNP: 2615
ClinVar: 2615
TCGA: ENSG00000137507
COSMIC: LRRC32

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137507ENST00000260061Q14392
ENSG00000137507ENST00000260061A0A024R5J7
ENSG00000137507ENST00000404995Q14392
ENSG00000137507ENST00000404995A0A024R5J7
ENSG00000137507ENST00000407242Q14392
ENSG00000137507ENST00000407242A0A024R5J7
ENSG00000137507ENST00000421973C9JYU3

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
196516192009GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.171
219078642011Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.136
196665732009Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells.105
197504842009Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg.93
186289822008Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression.70
222787422012GARP regulates the bioavailability and activation of TGFβ.53
194535212009GARP: a key receptor controlling FOXP3 in human regulatory T cells.44
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
279134372016Surface Expression of TGFβ Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer.23
263570162015The GARP complex is required for cellular sphingolipid homeostasis.21

Citation

Dessen P

LRRC32 (leucine rich repeat containing 32)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55825/lrrc32