LRRC4 (leucine rich repeat containing 4)

2003-12-01  

Identity

HGNC
LRRC4
LOCATION
7q32.1
LOCUSID
64101
ALIAS
NAG14,NGL-2

Other Information

Locus ID:

NCBI: 64101
MIM: 610486
HGNC: 15586
Ensembl: ENSG00000128594

Variants:

dbSNP: 64101
ClinVar: 64101
TCGA: ENSG00000128594
COSMIC: LRRC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128594ENST00000249363Q9HBW1
ENSG00000128594ENST00000476782C9JA92
ENSG00000128594ENST00000478726C9J7K7
ENSG00000128594ENST00000494115C9J7V8

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Cell adhesion molecules (CAMs)KEGGko04514
Axon guidanceKEGGhsa04360
Cell adhesion molecules (CAMs)KEGGhsa04514

References

Pubmed IDYearTitleCitations
214353362011Interaction of hsa-miR-381 and glioma suppressor LRRC4 is involved in glioma growth.39
228346852012LRRC4 inhibits glioma cell growth and invasion through a miR-185-dependent pathway.23
244041522014Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4.22
278841602016The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells.17
276124242016Low expression of miR-381 is a favorite prognosis factor and enhances the chemosensitivity of osteosarcoma.15
189765072008Promoter hypermethylation-mediated inactivation of LRRC4 in gliomas.14
167235032006LRRC4, a putative tumor suppressor gene, requires a functional leucine-rich repeat cassette domain to inhibit proliferation of glioma cells in vitro by modulating the extracellular signal-regulated kinase/protein kinase B/nuclear factor-kappaB pathway.12
175419392008LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downregulating pleiotropic cytokine expression and responses.12
159674422005Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily.10
169410762006LRRC4 controls in vitro invasion of glioblastoma cells through inhibiting RPTP-zeta expression.5

Citation

Dessen P

LRRC4 (leucine rich repeat containing 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41203/lrrc4