Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

LRRC4 (leucine rich repeat containing 4)

Identity

Other namesNAG14
NGL-2
HGNC (Hugo) LRRC4
LocusID (NCBI) 64101
Atlas_Id 41203
Location 7q32.1
Location_base_pair Starts at 127667124 and ends at 127671002 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LRRC4   15586
Cards
Entrez_Gene (NCBI)LRRC4  64101  leucine rich repeat containing 4
GeneCards (Weizmann)LRRC4
Ensembl hg19 (Hinxton)ENSG00000128594 [Gene_View]  chr7:127667124-127671002 [Contig_View]  LRRC4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000128594 [Gene_View]  chr7:127667124-127671002 [Contig_View]  LRRC4 [Vega]
ICGC DataPortalENSG00000128594
TCGA cBioPortalLRRC4
AceView (NCBI)LRRC4
Genatlas (Paris)LRRC4
WikiGenes64101
SOURCE (Princeton)LRRC4
Genomic and cartography
GoldenPath hg19 (UCSC)LRRC4  -     chr7:127667124-127671002 -  7q32.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LRRC4  -     7q32.1   [Description]    (hg38-Dec_2013)
EnsemblLRRC4 - 7q32.1 [CytoView hg19]  LRRC4 - 7q32.1 [CytoView hg38]
Mapping of homologs : NCBILRRC4 [Mapview hg19]  LRRC4 [Mapview hg38]
OMIM610486   
Gene and transcription
Genbank (Entrez)AF196976 AI568859 AJ297858 AK172751 AK314047
RefSeq transcript (Entrez)NM_022143
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)LRRC4
Cluster EST : UnigeneHs.655003 [ NCBI ]
CGAP (NCI)Hs.655003
Alternative Splicing : Fast-db (Paris)GSHG0028555
Alternative Splicing GalleryENSG00000128594
Gene ExpressionLRRC4 [ NCBI-GEO ]     LRRC4 [ SEEK ]   LRRC4 [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)64101
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HBW1 (Uniprot)
NextProtQ9HBW1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HBW1
Splice isoforms : SwissVarQ9HBW1 (Swissvar)
PhosPhoSitePlusQ9HBW1
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    LRR (PS51450)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub2    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR-contain_N    LRR_5    Lrrc4   
Domain families : Pfam (Sanger)I-set (PF07679)    LRR_5 (PF13306)    LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam07679    pfam13306    pfam13855   
Domain families : Smart (EMBL)IGc2 (SM00408)  LRR_TYP (SM00369)  LRRCT (SM00082)  LRRNT (SM00013)  
DMDM Disease mutations64101
Blocks (Seattle)LRRC4
PDB (SRS)2DL9    3ZYI   
PDB (PDBSum)2DL9    3ZYI   
PDB (IMB)2DL9    3ZYI   
PDB (RSDB)2DL9    3ZYI   
Structural Biology KnowledgeBase2DL9    3ZYI   
SCOP (Structural Classification of Proteins)2DL9    3ZYI   
CATH (Classification of proteins structures)2DL9    3ZYI   
Human Protein AtlasENSG00000128594
Peptide AtlasQ9HBW1
HPRD10060
IPIIPI00005516   IPI00947006   IPI00947170   IPI00946827   
Protein Interaction databases
DIP (DOE-UCLA)Q9HBW1
IntAct (EBI)Q9HBW1
FunCoupENSG00000128594
BioGRIDLRRC4
IntegromeDBLRRC4
STRING (EMBL)LRRC4
ZODIACLRRC4
Ontologies - Pathways
QuickGOQ9HBW1
Ontology : AmiGOprotein kinase inhibitor activity  protein binding  cytoplasm  negative regulation of protein kinase activity  integral component of membrane  cytokine-mediated signaling pathway  cell junction  dendritic spine  postsynaptic membrane  negative regulation of JAK-STAT cascade  regulation of synapse organization  excitatory synapse  postsynaptic density protein 95 clustering  negative regulation of cyclin-dependent protein kinase activity  
Ontology : EGO-EBIprotein kinase inhibitor activity  protein binding  cytoplasm  negative regulation of protein kinase activity  integral component of membrane  cytokine-mediated signaling pathway  cell junction  dendritic spine  postsynaptic membrane  negative regulation of JAK-STAT cascade  regulation of synapse organization  excitatory synapse  postsynaptic density protein 95 clustering  negative regulation of cyclin-dependent protein kinase activity  
Pathways : KEGGAxon guidance    Cell adhesion molecules (CAMs)   
Protein Interaction DatabaseLRRC4
Atlas of Cancer Signalling NetworkLRRC4
Wikipedia pathwaysLRRC4
Orthology - Evolution
OrthoDB64101
GeneTree (enSembl)ENSG00000128594
Phylogenetic Trees/Animal Genes : TreeFamLRRC4
Homologs : HomoloGeneLRRC4
Homology/Alignments : Family Browser (UCSC)LRRC4
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerLRRC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRRC4
dbVarLRRC4
ClinVarLRRC4
1000_GenomesLRRC4 
Exome Variant ServerLRRC4
Exome Aggregation Consortium (ExAC)ENSG00000128594
SNP (GeneSNP Utah)LRRC4
SNP : HGBaseLRRC4
Genetic variants : HAPMAPLRRC4
Genomic Variants (DGV)LRRC4 [DGVbeta]
Mutations
ICGC Data PortalLRRC4 
TCGA Data PortalLRRC4 
Tumor PortalLRRC4
TCGA Copy Number PortalLRRC4
Somatic Mutations in Cancer : COSMICLRRC4 
BioMutasearch LRRC4
DgiDB (Drug Gene Interaction Database)LRRC4
DoCM (Curated mutations)LRRC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRRC4 (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:127667124-127671002
CONAN: Copy Number AnalysisLRRC4 
Mutations and Diseases : HGMDLRRC4
OMIM610486   
MedgenLRRC4
NextProtQ9HBW1 [Medical]
TSGene64101
GENETestsLRRC4
Huge Navigator LRRC4 [HugePedia]  LRRC4 [HugeCancerGEM]
snp3D : Map Gene to Disease64101
BioCentury BCIQLRRC4
General knowledge
Chemical/Protein Interactions : CTD64101
Chemical/Pharm GKB GenePA30463
Clinical trialLRRC4
Other databases
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRRC4
GoPubMedLRRC4
iHOPLRRC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jan 16 18:57:19 CET 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.