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LRRC4 (leucine rich repeat containing 4)

Identity

Other namesNAG14
NGL-2
HGNC (Hugo) LRRC4
LocusID (NCBI) 64101
Atlas_Id 41203
Location 7q32.1
Location_base_pair Starts at 127667124 and ends at 127671002 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LRRC4   15586
Cards
Entrez_Gene (NCBI)LRRC4  64101  leucine rich repeat containing 4
GeneCards (Weizmann)LRRC4
Ensembl hg19 (Hinxton)ENSG00000128594 [Gene_View]  chr7:127667124-127671002 [Contig_View]  LRRC4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000128594 [Gene_View]  chr7:127667124-127671002 [Contig_View]  LRRC4 [Vega]
ICGC DataPortalENSG00000128594
TCGA cBioPortalLRRC4
AceView (NCBI)LRRC4
Genatlas (Paris)LRRC4
WikiGenes64101
SOURCE (Princeton)LRRC4
Genomic and cartography
GoldenPath hg19 (UCSC)LRRC4  -     chr7:127667124-127671002 -  7q32.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LRRC4  -     7q32.1   [Description]    (hg38-Dec_2013)
EnsemblLRRC4 - 7q32.1 [CytoView hg19]  LRRC4 - 7q32.1 [CytoView hg38]
Mapping of homologs : NCBILRRC4 [Mapview hg19]  LRRC4 [Mapview hg38]
OMIM610486   
Gene and transcription
Genbank (Entrez)AF196976 AI568859 AJ297858 AK172751 AK314047
RefSeq transcript (Entrez)NM_022143
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)LRRC4
Cluster EST : UnigeneHs.655003 [ NCBI ]
CGAP (NCI)Hs.655003
Alternative Splicing : Fast-db (Paris)GSHG0028555
Alternative Splicing GalleryENSG00000128594
Gene ExpressionLRRC4 [ NCBI-GEO ]     LRRC4 [ SEEK ]   LRRC4 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HBW1 (Uniprot)
NextProtQ9HBW1  [Medical]
With graphics : InterProQ9HBW1
Splice isoforms : SwissVarQ9HBW1 (Swissvar)
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    LRR (PS51450)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub2    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR-contain_N    LRR_5    Lrrc4   
Related proteins : CluSTrQ9HBW1
Domain families : Pfam (Sanger)I-set (PF07679)    LRR_5 (PF13306)    LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam07679    pfam13306    pfam13855   
Domain families : Smart (EMBL)IGc2 (SM00408)  LRR_TYP (SM00369)  LRRCT (SM00082)  LRRNT (SM00013)  
DMDM Disease mutations64101
Blocks (Seattle)Q9HBW1
PDB (SRS)2DL9    3ZYI   
PDB (PDBSum)2DL9    3ZYI   
PDB (IMB)2DL9    3ZYI   
PDB (RSDB)2DL9    3ZYI   
Human Protein AtlasENSG00000128594
Peptide AtlasQ9HBW1
HPRD10060
IPIIPI00005516   IPI00947006   IPI00947170   IPI00946827   
Protein Interaction databases
DIP (DOE-UCLA)Q9HBW1
IntAct (EBI)Q9HBW1
FunCoupENSG00000128594
BioGRIDLRRC4
IntegromeDBLRRC4
STRING (EMBL)LRRC4
Ontologies - Pathways
QuickGOQ9HBW1
Ontology : AmiGOprotein binding  integral component of membrane  cell junction  dendritic spine  postsynaptic membrane  regulation of synapse organization  synapse organization  excitatory synapse  postsynaptic density protein 95 clustering  
Ontology : EGO-EBIprotein binding  integral component of membrane  cell junction  dendritic spine  postsynaptic membrane  regulation of synapse organization  synapse organization  excitatory synapse  postsynaptic density protein 95 clustering  
Pathways : KEGGAxon guidance    Cell adhesion molecules (CAMs)   
Protein Interaction DatabaseLRRC4
DoCM (Curated mutations)LRRC4
Wikipedia pathwaysLRRC4
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerLRRC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRRC4
dbVarLRRC4
ClinVarLRRC4
1000_GenomesLRRC4 
Exome Variant ServerLRRC4
SNP (GeneSNP Utah)LRRC4
SNP : HGBaseLRRC4
Genetic variants : HAPMAPLRRC4
Genomic Variants (DGV)LRRC4 [DGVbeta]
Mutations
ICGC Data PortalLRRC4 
TCGA Data PortalLRRC4 
Tumor PortalLRRC4
Somatic Mutations in Cancer : COSMICLRRC4 
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:127667124-127671002
CONAN: Copy Number AnalysisLRRC4 
Mutations and Diseases : HGMDLRRC4
OMIM610486   
MedgenLRRC4
NextProtQ9HBW1 [Medical]
GENETestsLRRC4
Disease Genetic AssociationLRRC4
Huge Navigator LRRC4 [HugePedia]  LRRC4 [HugeCancerGEM]
snp3D : Map Gene to Disease64101
DGIdb (Drug Gene Interaction db)LRRC4
General knowledge
Homologs : HomoloGeneLRRC4
Homology/Alignments : Family Browser (UCSC)LRRC4
Phylogenetic Trees/Animal Genes : TreeFamLRRC4
Chemical/Protein Interactions : CTD64101
Chemical/Pharm GKB GenePA30463
Clinical trialLRRC4
Cancer Resource (Charite)ENSG00000128594
Other databases
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
CoreMineLRRC4
GoPubMedLRRC4
iHOPLRRC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 20 19:35:15 CEST 2015

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