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LRRC4 (leucine rich repeat containing 4)

Identity

Other namesNAG14
NGL-2
HGNC (Hugo) LRRC4
LocusID (NCBI) 64101
Atlas_Id 41203
Location 7q32.1  [Link to chromosome band 7q32]
Location_base_pair Starts at 127667124 and ends at 127671002 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LRRC4   15586
Cards
Entrez_Gene (NCBI)LRRC4  64101  leucine rich repeat containing 4
AliasesNAG14; NGL-2
GeneCards (Weizmann)LRRC4
Ensembl hg19 (Hinxton)ENSG00000128594 [Gene_View]  chr7:127667124-127671002 [Contig_View]  LRRC4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000128594 [Gene_View]  chr7:127667124-127671002 [Contig_View]  LRRC4 [Vega]
ICGC DataPortalENSG00000128594
TCGA cBioPortalLRRC4
AceView (NCBI)LRRC4
Genatlas (Paris)LRRC4
WikiGenes64101
SOURCE (Princeton)LRRC4
Genomic and cartography
GoldenPath hg19 (UCSC)LRRC4  -     chr7:127667124-127671002 -  7q32.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LRRC4  -     7q32.1   [Description]    (hg38-Dec_2013)
EnsemblLRRC4 - 7q32.1 [CytoView hg19]  LRRC4 - 7q32.1 [CytoView hg38]
Mapping of homologs : NCBILRRC4 [Mapview hg19]  LRRC4 [Mapview hg38]
OMIM610486   
Gene and transcription
Genbank (Entrez)AF196976 AI568859 AJ297858 AK172751 AK314047
RefSeq transcript (Entrez)NM_022143
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)LRRC4
Cluster EST : UnigeneHs.655003 [ NCBI ]
CGAP (NCI)Hs.655003
Alternative Splicing GalleryENSG00000128594
Gene ExpressionLRRC4 [ NCBI-GEO ]   LRRC4 [ EBI - ARRAY_EXPRESS ]   LRRC4 [ SEEK ]   LRRC4 [ MEM ]
Gene Expression Viewer (FireBrowse)LRRC4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64101
GTEX Portal (Tissue expression)LRRC4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HBW1 (Uniprot)
NextProtQ9HBW1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HBW1
Splice isoforms : SwissVarQ9HBW1 (Swissvar)
PhosPhoSitePlusQ9HBW1
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    LRR (PS51450)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub2    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    Lrrc4    LRRNT   
Domain families : Pfam (Sanger)I-set (PF07679)    LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam07679    pfam13855   
Domain families : Smart (EMBL)IGc2 (SM00408)  LRR_TYP (SM00369)  LRRCT (SM00082)  LRRNT (SM00013)  
DMDM Disease mutations64101
Blocks (Seattle)LRRC4
PDB (SRS)2DL9    3ZYI   
PDB (PDBSum)2DL9    3ZYI   
PDB (IMB)2DL9    3ZYI   
PDB (RSDB)2DL9    3ZYI   
Structural Biology KnowledgeBase2DL9    3ZYI   
SCOP (Structural Classification of Proteins)2DL9    3ZYI   
CATH (Classification of proteins structures)2DL9    3ZYI   
SuperfamilyQ9HBW1
Human Protein AtlasENSG00000128594
Peptide AtlasQ9HBW1
HPRD10060
IPIIPI00005516   IPI00947006   IPI00947170   IPI00946827   
Protein Interaction databases
DIP (DOE-UCLA)Q9HBW1
IntAct (EBI)Q9HBW1
FunCoupENSG00000128594
BioGRIDLRRC4
STRING (EMBL)LRRC4
ZODIACLRRC4
Ontologies - Pathways
QuickGOQ9HBW1
Ontology : AmiGOprotein kinase inhibitor activity  protein binding  cytoplasm  negative regulation of protein kinase activity  integral component of membrane  cytokine-mediated signaling pathway  cell junction  dendritic spine  postsynaptic membrane  negative regulation of JAK-STAT cascade  regulation of synapse organization  excitatory synapse  postsynaptic density protein 95 clustering  
Ontology : EGO-EBIprotein kinase inhibitor activity  protein binding  cytoplasm  negative regulation of protein kinase activity  integral component of membrane  cytokine-mediated signaling pathway  cell junction  dendritic spine  postsynaptic membrane  negative regulation of JAK-STAT cascade  regulation of synapse organization  excitatory synapse  postsynaptic density protein 95 clustering  
Pathways : KEGGAxon guidance    Cell adhesion molecules (CAMs)   
NDEx Network
Atlas of Cancer Signalling NetworkLRRC4
Wikipedia pathwaysLRRC4
Orthology - Evolution
OrthoDB64101
GeneTree (enSembl)ENSG00000128594
Phylogenetic Trees/Animal Genes : TreeFamLRRC4
Homologs : HomoloGeneLRRC4
Homology/Alignments : Family Browser (UCSC)LRRC4
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerLRRC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRRC4
dbVarLRRC4
ClinVarLRRC4
1000_GenomesLRRC4 
Exome Variant ServerLRRC4
ExAC (Exome Aggregation Consortium)LRRC4 (select the gene name)
Genetic variants : HAPMAP64101
Genomic Variants (DGV)LRRC4 [DGVbeta]
Mutations
ICGC Data PortalLRRC4 
TCGA Data PortalLRRC4 
Broad Tumor PortalLRRC4
OASIS PortalLRRC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRRC4 
BioMutasearch LRRC4
DgiDB (Drug Gene Interaction Database)LRRC4
DoCM (Curated mutations)LRRC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRRC4 (select a term)
intoGenLRRC4
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:127667124-127671002  ENSG00000128594
CONAN: Copy Number AnalysisLRRC4 
Mutations and Diseases : HGMDLRRC4
OMIM610486   
MedgenLRRC4
Genetic Testing Registry LRRC4
NextProtQ9HBW1 [Medical]
TSGene64101
GENETestsLRRC4
Huge Navigator LRRC4 [HugePedia]
snp3D : Map Gene to Disease64101
BioCentury BCIQLRRC4
ClinGenLRRC4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64101
Chemical/Pharm GKB GenePA30463
Clinical trialLRRC4
Miscellaneous
canSAR (ICR)LRRC4 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRRC4
EVEXLRRC4
GoPubMedLRRC4
iHOPLRRC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 9 19:26:25 CEST 2016

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