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LRRC41 (leucine rich repeat containing 41)

Identity

Alias_symbol (synonym)MUF1
Other aliasPP7759
HGNC (Hugo) LRRC41
LocusID (NCBI) 10489
Atlas_Id 54432
Location 1p34.1  [Link to chromosome band 1p34]
Location_base_pair Starts at 46278400 and ends at 46303366 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LRRC41 (1p34.1) / FAM159A (1p32.3)LRRC41 (1p34.1) / SERPINB6 (6p25.2)MTCL1 (18p11.22) / LRRC41 (1p34.1)
NANS (9q22.33) / LRRC41 (1p34.1)PIK3R3 (1p34.1) / LRRC41 (1p34.1)RAD54L (1p34.1) / LRRC41 (1p34.1)
CCDC165 LRRC41 1p34.1LRRC41 1p34.1 / FAM159A 1p32.3PIK3R3 1p34.1 / LRRC41 1p34.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;1)(p34;p34) PIK3R3/LRRC41
t(1;18)(p34;p11) MTCL1/LRRC41

External links

Nomenclature
HGNC (Hugo)LRRC41   16917
Cards
Entrez_Gene (NCBI)LRRC41  10489  leucine rich repeat containing 41
AliasesMUF1; PP7759
GeneCards (Weizmann)LRRC41
Ensembl hg19 (Hinxton)ENSG00000132128 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132128 [Gene_View]  chr1:46278400-46303366 [Contig_View]  LRRC41 [Vega]
ICGC DataPortalENSG00000132128
TCGA cBioPortalLRRC41
AceView (NCBI)LRRC41
Genatlas (Paris)LRRC41
WikiGenes10489
SOURCE (Princeton)LRRC41
Genetics Home Reference (NIH)LRRC41
Genomic and cartography
GoldenPath hg38 (UCSC)LRRC41  -     chr1:46278400-46303366 -  1p34.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LRRC41  -     1p34.1   [Description]    (hg19-Feb_2009)
EnsemblLRRC41 - 1p34.1 [CytoView hg19]  LRRC41 - 1p34.1 [CytoView hg38]
Mapping of homologs : NCBILRRC41 [Mapview hg19]  LRRC41 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF370430 AK024051 AK125827 AK223420 AK291283
RefSeq transcript (Entrez)NM_006369
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LRRC41
Cluster EST : UnigeneHs.144941 [ NCBI ]
CGAP (NCI)Hs.144941
Alternative Splicing GalleryENSG00000132128
Gene ExpressionLRRC41 [ NCBI-GEO ]   LRRC41 [ EBI - ARRAY_EXPRESS ]   LRRC41 [ SEEK ]   LRRC41 [ MEM ]
Gene Expression Viewer (FireBrowse)LRRC41 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10489
GTEX Portal (Tissue expression)LRRC41
Human Protein AtlasENSG00000132128-LRRC41 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15345   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15345  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15345
Splice isoforms : SwissVarQ15345
PhosPhoSitePlusQ15345
Domains : Interpro (EBI)L_dom-like    Leu_rpt_41   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)LRRC41
DMDM Disease mutations10489
Blocks (Seattle)LRRC41
SuperfamilyQ15345
Human Protein Atlas [tissue]ENSG00000132128-LRRC41 [tissue]
Peptide AtlasQ15345
HPRD10102
IPIIPI01019055   IPI00397577   IPI00397575   IPI00556182   
Protein Interaction databases
DIP (DOE-UCLA)Q15345
IntAct (EBI)Q15345
FunCoupENSG00000132128
BioGRIDLRRC41
STRING (EMBL)LRRC41
ZODIACLRRC41
Ontologies - Pathways
QuickGOQ15345
Ontology : AmiGOnucleus  cytoplasm  cytosol  membrane  protein ubiquitination  protein homodimerization activity  post-translational protein modification  
Ontology : EGO-EBInucleus  cytoplasm  cytosol  membrane  protein ubiquitination  protein homodimerization activity  post-translational protein modification  
NDEx NetworkLRRC41
Atlas of Cancer Signalling NetworkLRRC41
Wikipedia pathwaysLRRC41
Orthology - Evolution
OrthoDB10489
GeneTree (enSembl)ENSG00000132128
Phylogenetic Trees/Animal Genes : TreeFamLRRC41
HOVERGENQ15345
HOGENOMQ15345
Homologs : HomoloGeneLRRC41
Homology/Alignments : Family Browser (UCSC)LRRC41
Gene fusions - Rearrangements
Fusion : MitelmanLRRC41/FAM159A [1p34.1/1p32.3]  
Fusion : MitelmanMTCL1/LRRC41 [18p11.22/1p34.1]  [t(1;18)(p34;p11)]  
Fusion : MitelmanPIK3R3/LRRC41 [1p34.1/1p34.1]  [t(1;1)(p34;p34)]  
Fusion: TCGA_MDACCCCDC165 LRRC41 1p34.1 KIRC
Fusion: TCGA_MDACCLRRC41 1p34.1 FAM159A 1p32.3 KIRC
Fusion: TCGA_MDACCPIK3R3 1p34.1 LRRC41 1p34.1 BRCA
Fusion PortalCCDC165 LRRC41 1p34.1 KIRC
Fusion PortalLRRC41 1p34.1 FAM159A 1p32.3 KIRC
Fusion PortalPIK3R3 1p34.1 LRRC41 1p34.1 BRCA
Fusion : QuiverLRRC41
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRRC41 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRRC41
dbVarLRRC41
ClinVarLRRC41
1000_GenomesLRRC41 
Exome Variant ServerLRRC41
ExAC (Exome Aggregation Consortium)ENSG00000132128
GNOMAD BrowserENSG00000132128
Genetic variants : HAPMAP10489
Genomic Variants (DGV)LRRC41 [DGVbeta]
DECIPHERLRRC41 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLRRC41 
Mutations
ICGC Data PortalLRRC41 
TCGA Data PortalLRRC41 
Broad Tumor PortalLRRC41
OASIS PortalLRRC41 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRRC41  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLRRC41
BioMutasearch LRRC41
DgiDB (Drug Gene Interaction Database)LRRC41
DoCM (Curated mutations)LRRC41 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRRC41 (select a term)
intoGenLRRC41
Cancer3DLRRC41(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETLRRC41
MedgenLRRC41
Genetic Testing Registry LRRC41
NextProtQ15345 [Medical]
TSGene10489
GENETestsLRRC41
Target ValidationLRRC41
Huge Navigator LRRC41 [HugePedia]
snp3D : Map Gene to Disease10489
BioCentury BCIQLRRC41
ClinGenLRRC41
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10489
Chemical/Pharm GKB GenePA142671529
Clinical trialLRRC41
Miscellaneous
canSAR (ICR)LRRC41 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRRC41
EVEXLRRC41
GoPubMedLRRC41
iHOPLRRC41
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon May 14 11:57:38 CEST 2018
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