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LRRC4B (leucine rich repeat containing 4B)

Identity

Alias_namesLRIG4
leucine-rich repeats and immunoglobulin-like domains 4
Alias_symbol (synonym)DKFZp761A179
HSM
Other aliasNGL-3
HGNC (Hugo) LRRC4B
LocusID (NCBI) 94030
Atlas_Id 68634
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 50516893 and ends at 50568045 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EEF2 (19p13.3) / LRRC4B (19q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LRRC4B   25042
Cards
Entrez_Gene (NCBI)LRRC4B  94030  leucine rich repeat containing 4B
AliasesHSM; LRIG4; NGL-3
GeneCards (Weizmann)LRRC4B
Ensembl hg19 (Hinxton)ENSG00000131409 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000131409 [Gene_View]  chr19:50516893-50568045 [Contig_View]  LRRC4B [Vega]
ICGC DataPortalENSG00000131409
TCGA cBioPortalLRRC4B
AceView (NCBI)LRRC4B
Genatlas (Paris)LRRC4B
WikiGenes94030
SOURCE (Princeton)LRRC4B
Genetics Home Reference (NIH)LRRC4B
Genomic and cartography
GoldenPath hg38 (UCSC)LRRC4B  -     chr19:50516893-50568045 -  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LRRC4B  -     19q13.33   [Description]    (hg19-Feb_2009)
EnsemblLRRC4B - 19q13.33 [CytoView hg19]  LRRC4B - 19q13.33 [CytoView hg38]
Mapping of homologs : NCBILRRC4B [Mapview hg19]  LRRC4B [Mapview hg38]
Gene and transcription
Genbank (Entrez)AL137451 BC019687 BC032460 BC056207 BC131897
RefSeq transcript (Entrez)NM_001080457 NM_001348568
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LRRC4B
Cluster EST : UnigeneHs.120873 [ NCBI ]
CGAP (NCI)Hs.120873
Alternative Splicing GalleryENSG00000131409
Gene ExpressionLRRC4B [ NCBI-GEO ]   LRRC4B [ EBI - ARRAY_EXPRESS ]   LRRC4B [ SEEK ]   LRRC4B [ MEM ]
Gene Expression Viewer (FireBrowse)LRRC4B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)94030
GTEX Portal (Tissue expression)LRRC4B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NT99   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NT99  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NT99
Splice isoforms : SwissVarQ9NT99
PhosPhoSitePlusQ9NT99
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    LRR (PS51450)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRRC4B    LRRNT   
Domain families : Pfam (Sanger)I-set (PF07679)    LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam07679    pfam13855   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  LRR_TYP (SM00369)  LRRCT (SM00082)  LRRNT (SM00013)  
Conserved Domain (NCBI)LRRC4B
DMDM Disease mutations94030
Blocks (Seattle)LRRC4B
SuperfamilyQ9NT99
Human Protein AtlasENSG00000131409
Peptide AtlasQ9NT99
IPIIPI00300241   IPI00976655   
Protein Interaction databases
DIP (DOE-UCLA)Q9NT99
IntAct (EBI)Q9NT99
FunCoupENSG00000131409
BioGRIDLRRC4B
STRING (EMBL)LRRC4B
ZODIACLRRC4B
Ontologies - Pathways
QuickGOQ9NT99
Ontology : AmiGOprotein kinase inhibitor activity  receptor binding  cytoplasm  negative regulation of protein kinase activity  integral component of membrane  cytokine-mediated signaling pathway  cell junction  presynaptic membrane  cerebellar mossy fiber  negative regulation of JAK-STAT cascade  positive regulation of synapse assembly  
Ontology : EGO-EBIprotein kinase inhibitor activity  receptor binding  cytoplasm  negative regulation of protein kinase activity  integral component of membrane  cytokine-mediated signaling pathway  cell junction  presynaptic membrane  cerebellar mossy fiber  negative regulation of JAK-STAT cascade  positive regulation of synapse assembly  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkLRRC4B
Atlas of Cancer Signalling NetworkLRRC4B
Wikipedia pathwaysLRRC4B
Orthology - Evolution
OrthoDB94030
GeneTree (enSembl)ENSG00000131409
Phylogenetic Trees/Animal Genes : TreeFamLRRC4B
HOVERGENQ9NT99
HOGENOMQ9NT99
Homologs : HomoloGeneLRRC4B
Homology/Alignments : Family Browser (UCSC)LRRC4B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRRC4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRRC4B
dbVarLRRC4B
ClinVarLRRC4B
1000_GenomesLRRC4B 
Exome Variant ServerLRRC4B
ExAC (Exome Aggregation Consortium)LRRC4B (select the gene name)
Genetic variants : HAPMAP94030
Genomic Variants (DGV)LRRC4B [DGVbeta]
DECIPHERLRRC4B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLRRC4B 
Mutations
ICGC Data PortalLRRC4B 
TCGA Data PortalLRRC4B 
Broad Tumor PortalLRRC4B
OASIS PortalLRRC4B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRRC4B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLRRC4B
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LRRC4B
DgiDB (Drug Gene Interaction Database)LRRC4B
DoCM (Curated mutations)LRRC4B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRRC4B (select a term)
intoGenLRRC4B
Cancer3DLRRC4B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenLRRC4B
Genetic Testing Registry LRRC4B
NextProtQ9NT99 [Medical]
TSGene94030
GENETestsLRRC4B
Target ValidationLRRC4B
Huge Navigator LRRC4B [HugePedia]
snp3D : Map Gene to Disease94030
BioCentury BCIQLRRC4B
ClinGenLRRC4B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD94030
Chemical/Pharm GKB GenePA134890612
Clinical trialLRRC4B
Miscellaneous
canSAR (ICR)LRRC4B (select the gene name)
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRRC4B
EVEXLRRC4B
GoPubMedLRRC4B
iHOPLRRC4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:24:56 CEST 2017

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