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LRRC4C (leucine rich repeat containing 4C)

Identity

Alias_symbol (synonym)KIAA1580
NGL-1
Other aliasNGL1
HGNC (Hugo) LRRC4C
LocusID (NCBI) 57689
Atlas_Id 68635
Location 11p12  [Link to chromosome band 11p12]
Location_base_pair Starts at 40114201 and ends at 41459636 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LRRC4C (11p12) / RPS8 (1p34.1)NUDCD3 (7p13) / LRRC4C (11p12)RASGRP1 (15q14) / LRRC4C (11p12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LRRC4C   29317
Cards
Entrez_Gene (NCBI)LRRC4C  57689  leucine rich repeat containing 4C
AliasesNGL-1; NGL1
GeneCards (Weizmann)LRRC4C
Ensembl hg19 (Hinxton)ENSG00000148948 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148948 [Gene_View]  chr11:40114201-41459636 [Contig_View]  LRRC4C [Vega]
ICGC DataPortalENSG00000148948
TCGA cBioPortalLRRC4C
AceView (NCBI)LRRC4C
Genatlas (Paris)LRRC4C
WikiGenes57689
SOURCE (Princeton)LRRC4C
Genetics Home Reference (NIH)LRRC4C
Genomic and cartography
GoldenPath hg38 (UCSC)LRRC4C  -     chr11:40114201-41459636 -  11p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LRRC4C  -     11p12   [Description]    (hg19-Feb_2009)
EnsemblLRRC4C - 11p12 [CytoView hg19]  LRRC4C - 11p12 [CytoView hg38]
Mapping of homologs : NCBILRRC4C [Mapview hg19]  LRRC4C [Mapview hg38]
OMIM608817   
Gene and transcription
Genbank (Entrez)AB046800 AI806109 AK289646 AY358293 BC041374
RefSeq transcript (Entrez)NM_001258419 NM_020929
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LRRC4C
Cluster EST : UnigeneHs.745123 [ NCBI ]
CGAP (NCI)Hs.745123
Alternative Splicing GalleryENSG00000148948
Gene ExpressionLRRC4C [ NCBI-GEO ]   LRRC4C [ EBI - ARRAY_EXPRESS ]   LRRC4C [ SEEK ]   LRRC4C [ MEM ]
Gene Expression Viewer (FireBrowse)LRRC4C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57689
GTEX Portal (Tissue expression)LRRC4C
Human Protein AtlasENSG00000148948-LRRC4C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCJ2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCJ2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCJ2
Splice isoforms : SwissVarQ9HCJ2
PhosPhoSitePlusQ9HCJ2
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    LRR (PS51450)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    Ig_V-set    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR_5    LRRC4C    LRRNT   
Domain families : Pfam (Sanger)I-set (PF07679)    LRR_5 (PF13306)    LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam07679    pfam13306    pfam13855   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  IGv (SM00406)  LRR_TYP (SM00369)  LRRNT (SM00013)  
Conserved Domain (NCBI)LRRC4C
DMDM Disease mutations57689
Blocks (Seattle)LRRC4C
PDB (SRS)3ZYJ   
PDB (PDBSum)3ZYJ   
PDB (IMB)3ZYJ   
PDB (RSDB)3ZYJ   
Structural Biology KnowledgeBase3ZYJ   
SCOP (Structural Classification of Proteins)3ZYJ   
CATH (Classification of proteins structures)3ZYJ   
SuperfamilyQ9HCJ2
Human Protein Atlas [tissue]ENSG00000148948-LRRC4C [tissue]
Peptide AtlasQ9HCJ2
HPRD12303
IPIIPI00014223   IPI00977241   
Protein Interaction databases
DIP (DOE-UCLA)Q9HCJ2
IntAct (EBI)Q9HCJ2
FunCoupENSG00000148948
BioGRIDLRRC4C
STRING (EMBL)LRRC4C
ZODIACLRRC4C
Ontologies - Pathways
QuickGOQ9HCJ2
Ontology : AmiGOprotein kinase inhibitor activity  protein binding  extracellular space  cytoplasm  negative regulation of protein kinase activity  membrane  integral component of membrane  cytokine-mediated signaling pathway  cell junction  postsynaptic membrane  negative regulation of JAK-STAT cascade  regulation of axonogenesis  
Ontology : EGO-EBIprotein kinase inhibitor activity  protein binding  extracellular space  cytoplasm  negative regulation of protein kinase activity  membrane  integral component of membrane  cytokine-mediated signaling pathway  cell junction  postsynaptic membrane  negative regulation of JAK-STAT cascade  regulation of axonogenesis  
Pathways : KEGGAxon guidance    Cell adhesion molecules (CAMs)   
NDEx NetworkLRRC4C
Atlas of Cancer Signalling NetworkLRRC4C
Wikipedia pathwaysLRRC4C
Orthology - Evolution
OrthoDB57689
GeneTree (enSembl)ENSG00000148948
Phylogenetic Trees/Animal Genes : TreeFamLRRC4C
HOVERGENQ9HCJ2
HOGENOMQ9HCJ2
Homologs : HomoloGeneLRRC4C
Homology/Alignments : Family Browser (UCSC)LRRC4C
Gene fusions - Rearrangements
Fusion: Tumor Portal LRRC4C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRRC4C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRRC4C
dbVarLRRC4C
ClinVarLRRC4C
1000_GenomesLRRC4C 
Exome Variant ServerLRRC4C
ExAC (Exome Aggregation Consortium)ENSG00000148948
GNOMAD BrowserENSG00000148948
Genetic variants : HAPMAP57689
Genomic Variants (DGV)LRRC4C [DGVbeta]
DECIPHERLRRC4C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLRRC4C 
Mutations
ICGC Data PortalLRRC4C 
TCGA Data PortalLRRC4C 
Broad Tumor PortalLRRC4C
OASIS PortalLRRC4C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRRC4C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLRRC4C
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch LRRC4C
DgiDB (Drug Gene Interaction Database)LRRC4C
DoCM (Curated mutations)LRRC4C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRRC4C (select a term)
intoGenLRRC4C
Cancer3DLRRC4C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608817   
Orphanet
MedgenLRRC4C
Genetic Testing Registry LRRC4C
NextProtQ9HCJ2 [Medical]
TSGene57689
GENETestsLRRC4C
Target ValidationLRRC4C
Huge Navigator LRRC4C [HugePedia]
snp3D : Map Gene to Disease57689
BioCentury BCIQLRRC4C
ClinGenLRRC4C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57689
Chemical/Pharm GKB GenePA142671534
Clinical trialLRRC4C
Miscellaneous
canSAR (ICR)LRRC4C (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRRC4C
EVEXLRRC4C
GoPubMedLRRC4C
iHOPLRRC4C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:11:42 CET 2017

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