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LRRC8B (leucine rich repeat containing 8 VRAC subunit B)

Identity

Alias (NCBI)TA-LRRP
TALRRP
HGNC (Hugo) LRRC8B
HGNC Alias symbTA-LRRP
KIAA0231
HGNC Alias nameT cell activation leucine repeat rich protein
LocusID (NCBI) 23507
Atlas_Id 68657
Location 1p22.2  [Link to chromosome band 1p22]
Location_base_pair Starts at 89524829 and ends at 89597861 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LRRC8B (1p22.2) / LRRC8C (1p22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)LRRC8B   30692
Cards
Entrez_Gene (NCBI)LRRC8B    leucine rich repeat containing 8 VRAC subunit B
AliasesTA-LRRP; TALRRP
GeneCards (Weizmann)LRRC8B
Ensembl hg19 (Hinxton)ENSG00000197147 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197147 [Gene_View]  ENSG00000197147 [Sequence]  chr1:89524829-89597861 [Contig_View]  LRRC8B [Vega]
ICGC DataPortalENSG00000197147
TCGA cBioPortalLRRC8B
AceView (NCBI)LRRC8B
Genatlas (Paris)LRRC8B
SOURCE (Princeton)LRRC8B
Genetics Home Reference (NIH)LRRC8B
Genomic and cartography
GoldenPath hg38 (UCSC)LRRC8B  -     chr1:89524829-89597861 +  1p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LRRC8B  -     1p22.2   [Description]    (hg19-Feb_2009)
GoldenPathLRRC8B - 1p22.2 [CytoView hg19]  LRRC8B - 1p22.2 [CytoView hg38]
ImmunoBaseENSG00000197147
Genome Data Viewer NCBILRRC8B [Mapview hg19]  
OMIM612888   
Gene and transcription
Genbank (Entrez)AF385436 AW022123 AY358112 AY640232 BC030607
RefSeq transcript (Entrez)NM_001134476 NM_001369817 NM_001369819 NM_015350
Consensus coding sequences : CCDS (NCBI)LRRC8B
Gene ExpressionLRRC8B [ NCBI-GEO ]   LRRC8B [ EBI - ARRAY_EXPRESS ]   LRRC8B [ SEEK ]   LRRC8B [ MEM ]
Gene Expression Viewer (FireBrowse)LRRC8B [ Firebrowse - Broad ]
GenevisibleExpression of LRRC8B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23507
GTEX Portal (Tissue expression)LRRC8B
Human Protein AtlasENSG00000197147-LRRC8B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6P9F7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6P9F7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6P9F7
PhosPhoSitePlusQ6P9F7
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR_5    LRR_dom_sf    LRRC8_Pannexin-like   
Domain families : Pfam (Sanger)LRR_5 (PF13306)    LRR_8 (PF13855)    Pannexin_like (PF12534)   
Domain families : Pfam (NCBI)pfam13306    pfam13855    pfam12534   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  
Conserved Domain (NCBI)LRRC8B
SuperfamilyQ6P9F7
AlphaFold pdb e-kbQ6P9F7   
Human Protein Atlas [tissue]ENSG00000197147-LRRC8B [tissue]
HPRD18145
Protein Interaction databases
DIP (DOE-UCLA)Q6P9F7
IntAct (EBI)Q6P9F7
BioGRIDLRRC8B
STRING (EMBL)LRRC8B
ZODIACLRRC8B
Ontologies - Pathways
QuickGOQ6P9F7
Ontology : AmiGOvolume-sensitive anion channel activity  protein binding  cytoplasm  endoplasmic reticulum membrane  plasma membrane  plasma membrane  integral component of plasma membrane  inorganic anion transport  ion channel complex  transmembrane transport  anion transmembrane transport  
Ontology : EGO-EBIvolume-sensitive anion channel activity  protein binding  cytoplasm  endoplasmic reticulum membrane  plasma membrane  plasma membrane  integral component of plasma membrane  inorganic anion transport  ion channel complex  transmembrane transport  anion transmembrane transport  
NDEx NetworkLRRC8B
Atlas of Cancer Signalling NetworkLRRC8B
Wikipedia pathwaysLRRC8B
Orthology - Evolution
OrthoDB23507
GeneTree (enSembl)ENSG00000197147
Phylogenetic Trees/Animal Genes : TreeFamLRRC8B
Homologs : HomoloGeneLRRC8B
Homology/Alignments : Family Browser (UCSC)LRRC8B
Gene fusions - Rearrangements
Fusion : QuiverLRRC8B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRRC8B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRRC8B
dbVarLRRC8B
ClinVarLRRC8B
MonarchLRRC8B
1000_GenomesLRRC8B 
Exome Variant ServerLRRC8B
GNOMAD BrowserENSG00000197147
Varsome BrowserLRRC8B
ACMGLRRC8B variants
VarityQ6P9F7
Genomic Variants (DGV)LRRC8B [DGVbeta]
DECIPHERLRRC8B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLRRC8B 
Mutations
ICGC Data PortalLRRC8B 
TCGA Data PortalLRRC8B 
Broad Tumor PortalLRRC8B
OASIS PortalLRRC8B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRRC8B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLRRC8B
Mutations and Diseases : HGMDLRRC8B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLRRC8B
DgiDB (Drug Gene Interaction Database)LRRC8B
DoCM (Curated mutations)LRRC8B
CIViC (Clinical Interpretations of Variants in Cancer)LRRC8B
Cancer3DLRRC8B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612888   
Orphanet
DisGeNETLRRC8B
MedgenLRRC8B
Genetic Testing Registry LRRC8B
NextProtQ6P9F7 [Medical]
GENETestsLRRC8B
Target ValidationLRRC8B
Huge Navigator LRRC8B [HugePedia]
ClinGenLRRC8B
Clinical trials, drugs, therapy
MyCancerGenomeLRRC8B
Protein Interactions : CTDLRRC8B
Pharm GKB GenePA142671535
PharosQ6P9F7
Clinical trialLRRC8B
Miscellaneous
canSAR (ICR)LRRC8B
HarmonizomeLRRC8B
DataMed IndexLRRC8B
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLRRC8B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:06:25 CEST 2021

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