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LRRCC1 (leucine rich repeat and coiled-coil centrosomal protein 1)

Identity

Alias_namesleucine rich repeat and coiled-coil domain containing 1
Alias_symbol (synonym)KIAA1764
CLERC
VFL1
Other aliasSAP2
HGNC (Hugo) LRRCC1
LocusID (NCBI) 85444
Atlas_Id 68661
Location 8q21.2  [Link to chromosome band 8q21]
Location_base_pair Starts at 85107088 and ends at 85146079 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ASAP1 (8q24.21) / LRRCC1 (8q21.2)LRRCC1 (8q21.2) / CNTN5 (11q22.1)LRRCC1 (8q21.2) / MTG2 (20q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(8;8)(q21;q24) ASAP1/LRRCC1
t(8;20)(q21;q13) LRRCC1/MTG2

External links

Nomenclature
HGNC (Hugo)LRRCC1   29373
Cards
Entrez_Gene (NCBI)LRRCC1  85444  leucine rich repeat and coiled-coil centrosomal protein 1
AliasesCLERC; SAP2; VFL1
GeneCards (Weizmann)LRRCC1
Ensembl hg19 (Hinxton)ENSG00000133739 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133739 [Gene_View]  chr8:85107088-85146079 [Contig_View]  LRRCC1 [Vega]
ICGC DataPortalENSG00000133739
TCGA cBioPortalLRRCC1
AceView (NCBI)LRRCC1
Genatlas (Paris)LRRCC1
WikiGenes85444
SOURCE (Princeton)LRRCC1
Genetics Home Reference (NIH)LRRCC1
Genomic and cartography
GoldenPath hg38 (UCSC)LRRCC1  -     chr8:85107088-85146079 +  8q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LRRCC1  -     8q21.2   [Description]    (hg19-Feb_2009)
EnsemblLRRCC1 - 8q21.2 [CytoView hg19]  LRRCC1 - 8q21.2 [CytoView hg38]
Mapping of homologs : NCBILRRCC1 [Mapview hg19]  LRRCC1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA000990 AB051551 AK056185 AK057990 AK300234
RefSeq transcript (Entrez)NM_001077501 NM_001349636 NM_001349637 NM_001349638 NM_001349639 NM_033402
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LRRCC1
Cluster EST : UnigeneHs.193115 [ NCBI ]
CGAP (NCI)Hs.193115
Alternative Splicing GalleryENSG00000133739
Gene ExpressionLRRCC1 [ NCBI-GEO ]   LRRCC1 [ EBI - ARRAY_EXPRESS ]   LRRCC1 [ SEEK ]   LRRCC1 [ MEM ]
Gene Expression Viewer (FireBrowse)LRRCC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)85444
GTEX Portal (Tissue expression)LRRCC1
Human Protein AtlasENSG00000133739-LRRCC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9C099   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9C099  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9C099
Splice isoforms : SwissVarQ9C099
PhosPhoSitePlusQ9C099
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)L_dom-like    Leu-rich_rpt   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)LRRCC1
DMDM Disease mutations85444
Blocks (Seattle)LRRCC1
SuperfamilyQ9C099
Human Protein Atlas [tissue]ENSG00000133739-LRRCC1 [tissue]
Peptide AtlasQ9C099
HPRD11160
IPIIPI00477245   IPI00893851   IPI00909408   IPI00981788   IPI00984254   
Protein Interaction databases
DIP (DOE-UCLA)Q9C099
IntAct (EBI)Q9C099
FunCoupENSG00000133739
BioGRIDLRRCC1
STRING (EMBL)LRRCC1
ZODIACLRRCC1
Ontologies - Pathways
QuickGOQ9C099
Ontology : AmiGOcentrosome  centriole  cell cycle  cell division  
Ontology : EGO-EBIcentrosome  centriole  cell cycle  cell division  
NDEx NetworkLRRCC1
Atlas of Cancer Signalling NetworkLRRCC1
Wikipedia pathwaysLRRCC1
Orthology - Evolution
OrthoDB85444
GeneTree (enSembl)ENSG00000133739
Phylogenetic Trees/Animal Genes : TreeFamLRRCC1
HOVERGENQ9C099
HOGENOMQ9C099
Homologs : HomoloGeneLRRCC1
Homology/Alignments : Family Browser (UCSC)LRRCC1
Gene fusions - Rearrangements
Fusion : QuiverLRRCC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRRCC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRRCC1
dbVarLRRCC1
ClinVarLRRCC1
1000_GenomesLRRCC1 
Exome Variant ServerLRRCC1
ExAC (Exome Aggregation Consortium)ENSG00000133739
GNOMAD BrowserENSG00000133739
Genetic variants : HAPMAP85444
Genomic Variants (DGV)LRRCC1 [DGVbeta]
DECIPHERLRRCC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLRRCC1 
Mutations
ICGC Data PortalLRRCC1 
TCGA Data PortalLRRCC1 
Broad Tumor PortalLRRCC1
OASIS PortalLRRCC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRRCC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLRRCC1
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch LRRCC1
DgiDB (Drug Gene Interaction Database)LRRCC1
DoCM (Curated mutations)LRRCC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRRCC1 (select a term)
intoGenLRRCC1
Cancer3DLRRCC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETLRRCC1
MedgenLRRCC1
Genetic Testing Registry LRRCC1
NextProtQ9C099 [Medical]
TSGene85444
GENETestsLRRCC1
Target ValidationLRRCC1
Huge Navigator LRRCC1 [HugePedia]
snp3D : Map Gene to Disease85444
BioCentury BCIQLRRCC1
ClinGenLRRCC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD85444
Chemical/Pharm GKB GenePA142671519
Clinical trialLRRCC1
Miscellaneous
canSAR (ICR)LRRCC1 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRRCC1
EVEXLRRCC1
GoPubMedLRRCC1
iHOPLRRCC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Feb 23 18:38:46 CET 2018
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