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LRRFIP1 (LRR binding FLII interacting protein 1)

Identity

Alias (NCBI)FLAP-1
FLAP1
FLIIAP1
GCF-2
GCF2
HUFI-1
TRIP
HGNC (Hugo) LRRFIP1
HGNC Alias symbFLAP-1
FLIIAP1
TRIP
GCF-2
HUFI-1
GCF2
HGNC Alias nameGC-binding factor 2
HGNC Previous nameleucine rich repeat (in FLII) interacting protein 1
LocusID (NCBI) 9208
Atlas_Id 53021
Location 2q37.3  [Link to chromosome band 2q37]
Location_base_pair Starts at 237692205 and ends at 237765915 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARMC9 (2q37.1) / LRRFIP1 (2q37.3)C19orf43 (19p13.2) / LRRFIP1 (2q37.3)COPA (1q23.2) / LRRFIP1 (2q37.3)
EIF3A (10q26.11) / LRRFIP1 (2q37.3)LRRFIP1 (2q37.3) / CALCOCO2 (17q21.32)LRRFIP1 (2q37.3) / FGFR1 (8p11.23)
LRRFIP1 (2q37.3) / KIAA0319L (1p34.3)LRRFIP1 (2q37.3) / LRRFIP1 (2q37.3)LRRFIP1 (2q37.3) / MLPH (2q37.3)
LRRFIP1 (2q37.3) / NR3C1 (5q31.3)OLA1 (2q31.1) / LRRFIP1 (2q37.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  8p11 myeloproliferative syndrome (FGFR1)
t(2;8)(q37;p11) LRRFIP1/FGFR1


External links

 

Nomenclature
HGNC (Hugo)LRRFIP1   6702
Cards
Entrez_Gene (NCBI)LRRFIP1    LRR binding FLII interacting protein 1
AliasesFLAP-1; FLAP1; FLIIAP1; GCF-2; 
GCF2; HUFI-1; TRIP
GeneCards (Weizmann)LRRFIP1
Ensembl hg19 (Hinxton)ENSG00000124831 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124831 [Gene_View]  ENSG00000124831 [Sequence]  chr2:237692205-237765915 [Contig_View]  LRRFIP1 [Vega]
ICGC DataPortalENSG00000124831
TCGA cBioPortalLRRFIP1
AceView (NCBI)LRRFIP1
Genatlas (Paris)LRRFIP1
SOURCE (Princeton)LRRFIP1
Genetics Home Reference (NIH)LRRFIP1
Genomic and cartography
GoldenPath hg38 (UCSC)LRRFIP1  -     chr2:237692205-237765915 +  2q37.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LRRFIP1  -     2q37.3   [Description]    (hg19-Feb_2009)
GoldenPathLRRFIP1 - 2q37.3 [CytoView hg19]  LRRFIP1 - 2q37.3 [CytoView hg38]
ImmunoBaseENSG00000124831
Genome Data Viewer NCBILRRFIP1 [Mapview hg19]  
OMIM603256   
Gene and transcription
Genbank (Entrez)AA975133 AF115510 AJ223075 AK000884 AK298270
RefSeq transcript (Entrez)NM_001137550 NM_001137551 NM_001137552 NM_001137553 NM_004735
Consensus coding sequences : CCDS (NCBI)LRRFIP1
Gene ExpressionLRRFIP1 [ NCBI-GEO ]   LRRFIP1 [ EBI - ARRAY_EXPRESS ]   LRRFIP1 [ SEEK ]   LRRFIP1 [ MEM ]
Gene Expression Viewer (FireBrowse)LRRFIP1 [ Firebrowse - Broad ]
GenevisibleExpression of LRRFIP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9208
GTEX Portal (Tissue expression)LRRFIP1
Human Protein AtlasENSG00000124831-LRRFIP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ32MZ4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ32MZ4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ32MZ4
PhosPhoSitePlusQ32MZ4
Domains : Interpro (EBI)LRRFIP1/2   
Domain families : Pfam (Sanger)LRRFIP (PF09738)   
Domain families : Pfam (NCBI)pfam09738   
Conserved Domain (NCBI)LRRFIP1
PDB (RSDB)4H22   
PDB Europe4H22   
PDB (PDBSum)4H22   
PDB (IMB)4H22   
Structural Biology KnowledgeBase4H22   
SCOP (Structural Classification of Proteins)4H22   
CATH (Classification of proteins structures)4H22   
SuperfamilyQ32MZ4
AlphaFold pdb e-kbQ32MZ4   
Human Protein Atlas [tissue]ENSG00000124831-LRRFIP1 [tissue]
HPRD04460
Protein Interaction databases
DIP (DOE-UCLA)Q32MZ4
IntAct (EBI)Q32MZ4
BioGRIDLRRFIP1
STRING (EMBL)LRRFIP1
ZODIACLRRFIP1
Ontologies - Pathways
QuickGOQ32MZ4
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA binding  double-stranded RNA binding  protein binding  nucleus  cytoplasm  cytosol  cytosol  cytoskeleton  plasma membrane  regulation of transcription by RNA polymerase II  positive regulation of type I interferon production  protein homodimerization activity  cadherin binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA binding  double-stranded RNA binding  protein binding  nucleus  cytoplasm  cytosol  cytosol  cytoskeleton  plasma membrane  regulation of transcription by RNA polymerase II  positive regulation of type I interferon production  protein homodimerization activity  cadherin binding  
NDEx NetworkLRRFIP1
Atlas of Cancer Signalling NetworkLRRFIP1
Wikipedia pathwaysLRRFIP1
Orthology - Evolution
OrthoDB9208
GeneTree (enSembl)ENSG00000124831
Phylogenetic Trees/Animal Genes : TreeFamLRRFIP1
Homologs : HomoloGeneLRRFIP1
Homology/Alignments : Family Browser (UCSC)LRRFIP1
Gene fusions - Rearrangements
Fusion : QuiverLRRFIP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRRFIP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRRFIP1
dbVarLRRFIP1
ClinVarLRRFIP1
MonarchLRRFIP1
1000_GenomesLRRFIP1 
Exome Variant ServerLRRFIP1
GNOMAD BrowserENSG00000124831
Varsome BrowserLRRFIP1
ACMGLRRFIP1 variants
VarityQ32MZ4
Genomic Variants (DGV)LRRFIP1 [DGVbeta]
DECIPHERLRRFIP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLRRFIP1 
Mutations
ICGC Data PortalLRRFIP1 
TCGA Data PortalLRRFIP1 
Broad Tumor PortalLRRFIP1
OASIS PortalLRRFIP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRRFIP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLRRFIP1
Mutations and Diseases : HGMDLRRFIP1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLRRFIP1
DgiDB (Drug Gene Interaction Database)LRRFIP1
DoCM (Curated mutations)LRRFIP1
CIViC (Clinical Interpretations of Variants in Cancer)LRRFIP1
Cancer3DLRRFIP1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603256   
Orphanet
DisGeNETLRRFIP1
MedgenLRRFIP1
Genetic Testing Registry LRRFIP1
NextProtQ32MZ4 [Medical]
GENETestsLRRFIP1
Target ValidationLRRFIP1
Huge Navigator LRRFIP1 [HugePedia]
ClinGenLRRFIP1
Clinical trials, drugs, therapy
MyCancerGenomeLRRFIP1
Protein Interactions : CTDLRRFIP1
Pharm GKB GenePA30465
PharosQ32MZ4
Clinical trialLRRFIP1
Miscellaneous
canSAR (ICR)LRRFIP1
HarmonizomeLRRFIP1
DataMed IndexLRRFIP1
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLRRFIP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:17:09 CEST 2021

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