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LRRFIP1 (LRR binding FLII interacting protein 1)

Identity

Alias_namesleucine rich repeat (in FLII) interacting protein 1
Alias_symbol (synonym)FLAP-1
FLIIAP1
TRIP
GCF-2
HUFI-1
Other aliasFLAP1
GCF2
HGNC (Hugo) LRRFIP1
LocusID (NCBI) 9208
Atlas_Id 53021
Location 2q37.3  [Link to chromosome band 2q37]
Location_base_pair Starts at 237627581 and ends at 237781647 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARMC9 (2q37.1) / LRRFIP1 (2q37.3)C19orf43 (19p13.2) / LRRFIP1 (2q37.3)COPA (1q23.2) / LRRFIP1 (2q37.3)
EIF3A (10q26.11) / LRRFIP1 (2q37.3)LRRFIP1 (2q37.3) / CALCOCO2 (17q21.32)LRRFIP1 (2q37.3) / FGFR1 (8p11.23)
LRRFIP1 (2q37.3) / KIAA0319L (1p34.3)LRRFIP1 (2q37.3) / LRRFIP1 (2q37.3)LRRFIP1 (2q37.3) / MLPH (2q37.3)
LRRFIP1 (2q37.3) / NR3C1 (5q31.3)OLA1 (2q31.1) / LRRFIP1 (2q37.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  8p11 myeloproliferative syndrome (FGFR1)


External links

Nomenclature
HGNC (Hugo)LRRFIP1   6702
Cards
Entrez_Gene (NCBI)LRRFIP1  9208  LRR binding FLII interacting protein 1
AliasesFLAP-1; FLAP1; FLIIAP1; GCF-2; 
GCF2; HUFI-1; TRIP
GeneCards (Weizmann)LRRFIP1
Ensembl hg19 (Hinxton)ENSG00000124831 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124831 [Gene_View]  chr2:237627581-237781647 [Contig_View]  LRRFIP1 [Vega]
ICGC DataPortalENSG00000124831
TCGA cBioPortalLRRFIP1
AceView (NCBI)LRRFIP1
Genatlas (Paris)LRRFIP1
WikiGenes9208
SOURCE (Princeton)LRRFIP1
Genetics Home Reference (NIH)LRRFIP1
Genomic and cartography
GoldenPath hg38 (UCSC)LRRFIP1  -     chr2:237627581-237781647 +  2q37.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LRRFIP1  -     2q37.3   [Description]    (hg19-Feb_2009)
EnsemblLRRFIP1 - 2q37.3 [CytoView hg19]  LRRFIP1 - 2q37.3 [CytoView hg38]
Mapping of homologs : NCBILRRFIP1 [Mapview hg19]  LRRFIP1 [Mapview hg38]
OMIM603256   
Gene and transcription
Genbank (Entrez)AA975133 AF115510 AJ223075 AK000884 AK298270
RefSeq transcript (Entrez)NM_001137550 NM_001137551 NM_001137552 NM_001137553 NM_004735
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LRRFIP1
Cluster EST : UnigeneHs.471779 [ NCBI ]
CGAP (NCI)Hs.471779
Alternative Splicing GalleryENSG00000124831
Gene ExpressionLRRFIP1 [ NCBI-GEO ]   LRRFIP1 [ EBI - ARRAY_EXPRESS ]   LRRFIP1 [ SEEK ]   LRRFIP1 [ MEM ]
Gene Expression Viewer (FireBrowse)LRRFIP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9208
GTEX Portal (Tissue expression)LRRFIP1
Human Protein AtlasENSG00000124831-LRRFIP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ32MZ4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ32MZ4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ32MZ4
Splice isoforms : SwissVarQ32MZ4
PhosPhoSitePlusQ32MZ4
Domains : Interpro (EBI)LRRFIP1/2   
Domain families : Pfam (Sanger)LRRFIP (PF09738)   
Domain families : Pfam (NCBI)pfam09738   
Conserved Domain (NCBI)LRRFIP1
DMDM Disease mutations9208
Blocks (Seattle)LRRFIP1
PDB (SRS)4H22   
PDB (PDBSum)4H22   
PDB (IMB)4H22   
PDB (RSDB)4H22   
Structural Biology KnowledgeBase4H22   
SCOP (Structural Classification of Proteins)4H22   
CATH (Classification of proteins structures)4H22   
SuperfamilyQ32MZ4
Human Protein Atlas [tissue]ENSG00000124831-LRRFIP1 [tissue]
Peptide AtlasQ32MZ4
HPRD04460
IPIIPI00785113   IPI00006207   IPI00382733   IPI00914853   IPI00386687   IPI00853016   
Protein Interaction databases
DIP (DOE-UCLA)Q32MZ4
IntAct (EBI)Q32MZ4
FunCoupENSG00000124831
BioGRIDLRRFIP1
STRING (EMBL)LRRFIP1
ZODIACLRRFIP1
Ontologies - Pathways
QuickGOQ32MZ4
Ontology : AmiGODNA binding  double-stranded RNA binding  protein binding  cellular_component  nucleus  cytoplasm  cytosol  cytosol  cytoskeleton  plasma membrane  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  biological_process  positive regulation of type I interferon production  protein homodimerization activity  cadherin binding  negative regulation of transcription, DNA-templated  positive regulation of NF-kappaB transcription factor activity  
Ontology : EGO-EBIDNA binding  double-stranded RNA binding  protein binding  cellular_component  nucleus  cytoplasm  cytosol  cytosol  cytoskeleton  plasma membrane  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  biological_process  positive regulation of type I interferon production  protein homodimerization activity  cadherin binding  negative regulation of transcription, DNA-templated  positive regulation of NF-kappaB transcription factor activity  
NDEx NetworkLRRFIP1
Atlas of Cancer Signalling NetworkLRRFIP1
Wikipedia pathwaysLRRFIP1
Orthology - Evolution
OrthoDB9208
GeneTree (enSembl)ENSG00000124831
Phylogenetic Trees/Animal Genes : TreeFamLRRFIP1
HOVERGENQ32MZ4
HOGENOMQ32MZ4
Homologs : HomoloGeneLRRFIP1
Homology/Alignments : Family Browser (UCSC)LRRFIP1
Gene fusions - Rearrangements
Tumor Fusion PortalLRRFIP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRRFIP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRRFIP1
dbVarLRRFIP1
ClinVarLRRFIP1
1000_GenomesLRRFIP1 
Exome Variant ServerLRRFIP1
ExAC (Exome Aggregation Consortium)ENSG00000124831
GNOMAD BrowserENSG00000124831
Genetic variants : HAPMAP9208
Genomic Variants (DGV)LRRFIP1 [DGVbeta]
DECIPHERLRRFIP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLRRFIP1 
Mutations
ICGC Data PortalLRRFIP1 
TCGA Data PortalLRRFIP1 
Broad Tumor PortalLRRFIP1
OASIS PortalLRRFIP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRRFIP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLRRFIP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LRRFIP1
DgiDB (Drug Gene Interaction Database)LRRFIP1
DoCM (Curated mutations)LRRFIP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRRFIP1 (select a term)
intoGenLRRFIP1
Cancer3DLRRFIP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603256   
Orphanet
DisGeNETLRRFIP1
MedgenLRRFIP1
Genetic Testing Registry LRRFIP1
NextProtQ32MZ4 [Medical]
TSGene9208
GENETestsLRRFIP1
Target ValidationLRRFIP1
Huge Navigator LRRFIP1 [HugePedia]
snp3D : Map Gene to Disease9208
BioCentury BCIQLRRFIP1
ClinGenLRRFIP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9208
Chemical/Pharm GKB GenePA30465
Clinical trialLRRFIP1
Miscellaneous
canSAR (ICR)LRRFIP1 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRRFIP1
EVEXLRRFIP1
GoPubMedLRRFIP1
iHOPLRRFIP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:20:59 CET 2017

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