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LRRK1 (leucine rich repeat kinase 1)

Identity

Alias (NCBI)RIPK6
Roco1
HGNC (Hugo) LRRK1
HGNC Alias symbFLJ23119
KIAA1790
Roco1
RIPK6
LocusID (NCBI) 79705
Atlas_Id 68666
Location 15q26.3  [Link to chromosome band 15q26]
Location_base_pair Starts at 100919357 and ends at 101078256 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LRRK1 (15q26.3) / ADAMTS17 (15q26.3)LRRK1 (15q26.3) / GSTA4 (6p12.2)SLC9B1 (4q24) / LRRK1 (15q26.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)LRRK1   18608
Cards
Entrez_Gene (NCBI)LRRK1    leucine rich repeat kinase 1
AliasesRIPK6; Roco1
GeneCards (Weizmann)LRRK1
Ensembl hg19 (Hinxton)ENSG00000154237 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154237 [Gene_View]  ENSG00000154237 [Sequence]  chr15:100919357-101078256 [Contig_View]  LRRK1 [Vega]
ICGC DataPortalENSG00000154237
TCGA cBioPortalLRRK1
AceView (NCBI)LRRK1
Genatlas (Paris)LRRK1
SOURCE (Princeton)LRRK1
Genetics Home Reference (NIH)LRRK1
Genomic and cartography
GoldenPath hg38 (UCSC)LRRK1  -     chr15:100919357-101078256 +  15q26.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LRRK1  -     15q26.3   [Description]    (hg19-Feb_2009)
GoldenPathLRRK1 - 15q26.3 [CytoView hg19]  LRRK1 - 15q26.3 [CytoView hg38]
ImmunoBaseENSG00000154237
Genome Data Viewer NCBILRRK1 [Mapview hg19]  
OMIM610986   
Gene and transcription
Genbank (Entrez)AB058693 AK026772 AK054662 AK058028 AK094556
RefSeq transcript (Entrez)NM_024652
Consensus coding sequences : CCDS (NCBI)LRRK1
Gene ExpressionLRRK1 [ NCBI-GEO ]   LRRK1 [ EBI - ARRAY_EXPRESS ]   LRRK1 [ SEEK ]   LRRK1 [ MEM ]
Gene Expression Viewer (FireBrowse)LRRK1 [ Firebrowse - Broad ]
GenevisibleExpression of LRRK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79705
GTEX Portal (Tissue expression)LRRK1
Human Protein AtlasENSG00000154237-LRRK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ38SD2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ38SD2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ38SD2
PhosPhoSitePlusQ38SD2
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    LRR (PS51450)    PROTEIN_KINASE_DOM (PS50011)    ROC (PS51424)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Ankyrin_rpt-contain_sf    COR    Kinase-like_dom_sf    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR_dom_sf    P-loop_NTPase    Prot_kinase_dom    ROC_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)COR (PF16095)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam16095    pfam00069   
Domain families : Smart (EMBL)ANK (SM00248)  LRR_TYP (SM00369)  S_TKc (SM00220)  
Conserved Domain (NCBI)LRRK1
SuperfamilyQ38SD2
AlphaFold pdb e-kbQ38SD2   
Human Protein Atlas [tissue]ENSG00000154237-LRRK1 [tissue]
HPRD14319
Protein Interaction databases
DIP (DOE-UCLA)Q38SD2
IntAct (EBI)Q38SD2
BioGRIDLRRK1
STRING (EMBL)LRRK1
ZODIACLRRK1
Ontologies - Pathways
QuickGOQ38SD2
Ontology : AmiGOprotein serine/threonine phosphatase activity  protein binding  ATP binding  GTP binding  cytoplasm  mitochondrion  cytosol  protein phosphorylation  protein dephosphorylation  signal transduction  osteoclast development  identical protein binding  intracellular membrane-bounded organelle  bone resorption  metal ion binding  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of peptidyl-tyrosine phosphorylation  positive regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  protein serine kinase activity  protein threonine kinase activity  positive regulation of intracellular signal transduction  
Ontology : EGO-EBIprotein serine/threonine phosphatase activity  protein binding  ATP binding  GTP binding  cytoplasm  mitochondrion  cytosol  protein phosphorylation  protein dephosphorylation  signal transduction  osteoclast development  identical protein binding  intracellular membrane-bounded organelle  bone resorption  metal ion binding  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of peptidyl-tyrosine phosphorylation  positive regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  protein serine kinase activity  protein threonine kinase activity  positive regulation of intracellular signal transduction  
NDEx NetworkLRRK1
Atlas of Cancer Signalling NetworkLRRK1
Wikipedia pathwaysLRRK1
Orthology - Evolution
OrthoDB79705
GeneTree (enSembl)ENSG00000154237
Phylogenetic Trees/Animal Genes : TreeFamLRRK1
Homologs : HomoloGeneLRRK1
Homology/Alignments : Family Browser (UCSC)LRRK1
Gene fusions - Rearrangements
Fusion : QuiverLRRK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRRK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRRK1
dbVarLRRK1
ClinVarLRRK1
MonarchLRRK1
1000_GenomesLRRK1 
Exome Variant ServerLRRK1
GNOMAD BrowserENSG00000154237
Varsome BrowserLRRK1
ACMGLRRK1 variants
VarityQ38SD2
Genomic Variants (DGV)LRRK1 [DGVbeta]
DECIPHERLRRK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLRRK1 
Mutations
ICGC Data PortalLRRK1 
TCGA Data PortalLRRK1 
Broad Tumor PortalLRRK1
OASIS PortalLRRK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRRK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLRRK1
Mutations and Diseases : HGMDLRRK1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLRRK1
DgiDB (Drug Gene Interaction Database)LRRK1
DoCM (Curated mutations)LRRK1
CIViC (Clinical Interpretations of Variants in Cancer)LRRK1
Cancer3DLRRK1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610986   
Orphanet
DisGeNETLRRK1
MedgenLRRK1
Genetic Testing Registry LRRK1
NextProtQ38SD2 [Medical]
GENETestsLRRK1
Target ValidationLRRK1
Huge Navigator LRRK1 [HugePedia]
ClinGenLRRK1
Clinical trials, drugs, therapy
MyCancerGenomeLRRK1
Protein Interactions : CTDLRRK1
Pharm GKB GenePA134892363
PharosQ38SD2
Clinical trialLRRK1
Miscellaneous
canSAR (ICR)LRRK1
HarmonizomeLRRK1
DataMed IndexLRRK1
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLRRK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:06:27 CEST 2021

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