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LRRK1 (leucine rich repeat kinase 1)

Identity

Alias_symbol (synonym)FLJ23119
KIAA1790
Roco1
RIPK6
Other alias
HGNC (Hugo) LRRK1
LocusID (NCBI) 79705
Atlas_Id 68666
Location 15q26.3  [Link to chromosome band 15q26]
Location_base_pair Starts at 100919215 and ends at 101072889 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LRRK1 (15q26.3) / ADAMTS17 (15q26.3)LRRK1 (15q26.3) / GSTA4 (6p12.2)SLC9B1 (4q24) / LRRK1 (15q26.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LRRK1   18608
Cards
Entrez_Gene (NCBI)LRRK1  79705  leucine rich repeat kinase 1
AliasesRIPK6; Roco1
GeneCards (Weizmann)LRRK1
Ensembl hg19 (Hinxton)ENSG00000154237 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154237 [Gene_View]  chr15:100919215-101072889 [Contig_View]  LRRK1 [Vega]
ICGC DataPortalENSG00000154237
TCGA cBioPortalLRRK1
AceView (NCBI)LRRK1
Genatlas (Paris)LRRK1
WikiGenes79705
SOURCE (Princeton)LRRK1
Genetics Home Reference (NIH)LRRK1
Genomic and cartography
GoldenPath hg38 (UCSC)LRRK1  -     chr15:100919215-101072889 +  15q26.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LRRK1  -     15q26.3   [Description]    (hg19-Feb_2009)
EnsemblLRRK1 - 15q26.3 [CytoView hg19]  LRRK1 - 15q26.3 [CytoView hg38]
Mapping of homologs : NCBILRRK1 [Mapview hg19]  LRRK1 [Mapview hg38]
OMIM610986   
Gene and transcription
Genbank (Entrez)AB058693 AK026772 AK054662 AK058028 AK094556
RefSeq transcript (Entrez)NM_024652
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LRRK1
Cluster EST : UnigeneHs.407918 [ NCBI ]
CGAP (NCI)Hs.407918
Alternative Splicing GalleryENSG00000154237
Gene ExpressionLRRK1 [ NCBI-GEO ]   LRRK1 [ EBI - ARRAY_EXPRESS ]   LRRK1 [ SEEK ]   LRRK1 [ MEM ]
Gene Expression Viewer (FireBrowse)LRRK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79705
GTEX Portal (Tissue expression)LRRK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ38SD2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ38SD2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ38SD2
Splice isoforms : SwissVarQ38SD2
PhosPhoSitePlusQ38SD2
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    LRR (PS51450)    PROTEIN_KINASE_DOM (PS50011)    ROC (PS51424)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    COR    Kinase-like_dom    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    MIRO-like    P-loop_NTPase    Prot_kinase_dom    ROC_dom    WD40_repeat_dom   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    COR (PF16095)    Pkinase (PF00069)    Roc (PF08477)   
Domain families : Pfam (NCBI)pfam12796    pfam16095    pfam00069    pfam08477   
Domain families : Smart (EMBL)ANK (SM00248)  LRR_TYP (SM00369)  S_TKc (SM00220)  
Conserved Domain (NCBI)LRRK1
DMDM Disease mutations79705
Blocks (Seattle)LRRK1
SuperfamilyQ38SD2
Human Protein AtlasENSG00000154237
Peptide AtlasQ38SD2
HPRD14319
IPIIPI00748762   IPI00747813   IPI00980768   IPI01014785   IPI00942256   IPI00979091   IPI00977677   IPI00977243   
Protein Interaction databases
DIP (DOE-UCLA)Q38SD2
IntAct (EBI)Q38SD2
FunCoupENSG00000154237
BioGRIDLRRK1
STRING (EMBL)LRRK1
ZODIACLRRK1
Ontologies - Pathways
QuickGOQ38SD2
Ontology : AmiGOprotein serine/threonine kinase activity  signal transducer activity  protein binding  ATP binding  GTP binding  cytoplasm  mitochondrion  cytosol  protein phosphorylation  small GTPase mediated signal transduction  intracellular signal transduction  osteoclast development  identical protein binding  bone resorption  metal ion binding  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of peptidyl-tyrosine phosphorylation  positive regulation of canonical Wnt signaling pathway  positive regulation of intracellular signal transduction  
Ontology : EGO-EBIprotein serine/threonine kinase activity  signal transducer activity  protein binding  ATP binding  GTP binding  cytoplasm  mitochondrion  cytosol  protein phosphorylation  small GTPase mediated signal transduction  intracellular signal transduction  osteoclast development  identical protein binding  bone resorption  metal ion binding  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of peptidyl-tyrosine phosphorylation  positive regulation of canonical Wnt signaling pathway  positive regulation of intracellular signal transduction  
NDEx NetworkLRRK1
Atlas of Cancer Signalling NetworkLRRK1
Wikipedia pathwaysLRRK1
Orthology - Evolution
OrthoDB79705
GeneTree (enSembl)ENSG00000154237
Phylogenetic Trees/Animal Genes : TreeFamLRRK1
HOVERGENQ38SD2
HOGENOMQ38SD2
Homologs : HomoloGeneLRRK1
Homology/Alignments : Family Browser (UCSC)LRRK1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRRK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRRK1
dbVarLRRK1
ClinVarLRRK1
1000_GenomesLRRK1 
Exome Variant ServerLRRK1
ExAC (Exome Aggregation Consortium)LRRK1 (select the gene name)
Genetic variants : HAPMAP79705
Genomic Variants (DGV)LRRK1 [DGVbeta]
DECIPHERLRRK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLRRK1 
Mutations
ICGC Data PortalLRRK1 
TCGA Data PortalLRRK1 
Broad Tumor PortalLRRK1
OASIS PortalLRRK1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDLRRK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LRRK1
DgiDB (Drug Gene Interaction Database)LRRK1
DoCM (Curated mutations)LRRK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRRK1 (select a term)
intoGenLRRK1
Cancer3DLRRK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610986   
Orphanet
MedgenLRRK1
Genetic Testing Registry LRRK1
NextProtQ38SD2 [Medical]
TSGene79705
GENETestsLRRK1
Target ValidationLRRK1
Huge Navigator LRRK1 [HugePedia]
snp3D : Map Gene to Disease79705
BioCentury BCIQLRRK1
ClinGenLRRK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79705
Chemical/Pharm GKB GenePA134892363
Clinical trialLRRK1
Miscellaneous
canSAR (ICR)LRRK1 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRRK1
EVEXLRRK1
GoPubMedLRRK1
iHOPLRRK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:26:37 CEST 2017

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