Atlas of Genetics and Cytogenetics in Oncology and Haematology


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LRTOMT (leucine rich transmembrane and O-methyltransferase domain containing)

Identity

Alias (NCBI)CFAP111
DFNB63
LRRC51
HGNC (Hugo) LRTOMT
HGNC Alias symbCOMT2
CFAP111
HGNC Previous nameLRRC51
 DFNB63
HGNC Previous nameleucine rich repeat containing 51
 deafness, autosomal recessive 63
LocusID (NCBI) 220074
Atlas_Id 68678
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 72080850 and ends at 72096892 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LRTOMT (11q13.4)::LRTOMT (11q13.4)LRTOMT (11q13.4)::METTL25 (12q21.31)LRTOMT (11q13.4)::MTSS1L (16q22.1)
LRTOMT (11q13.4)::NFIC (19p13.3)LRTOMT (11q13.4)::TOMM40 (19q13.32)LRTOMT (11q13.4)::UVRAG (11q13.5)
MDH1 (2p15)::LRTOMT (11q13.4)SHANK2 (11q13.3)::LRTOMT (11q13.4)UVRAG (11q13.5)::LRTOMT (11q13.4)
LRTOMT UVRAGLRTOMT NFICSHANK2 LRTOMT
UVRAG LRTOMT

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)LRTOMT   25033
Cards
Entrez_Gene (NCBI)LRTOMT    leucine rich transmembrane and O-methyltransferase domain containing
AliasesCFAP111; DFNB63; LRRC51
GeneCards (Weizmann)LRTOMT
Ensembl hg19 (Hinxton)ENSG00000184154 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184154 [Gene_View]  ENSG00000184154 [Sequence]  chr11:72080850-72096892 [Contig_View]  LRTOMT [Vega]
ICGC DataPortalENSG00000184154
TCGA cBioPortalLRTOMT
AceView (NCBI)LRTOMT
Genatlas (Paris)LRTOMT
SOURCE (Princeton)LRTOMT
Genetics Home Reference (NIH)LRTOMT
Genomic and cartography
GoldenPath hg38 (UCSC)LRTOMT  -     chr11:72080850-72096892 +  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LRTOMT  -     11q13.4   [Description]    (hg19-Feb_2009)
GoldenPathLRTOMT - 11q13.4 [CytoView hg19]  LRTOMT - 11q13.4 [CytoView hg38]
ImmunoBaseENSG00000184154
Genome Data Viewer NCBILRTOMT [Mapview hg19]  
OMIM611451   612414   
Gene and transcription
Genbank (Entrez)AF289588 AK302772 BC035223 BX115135 DA151871
RefSeq transcript (Entrez)NM_001145308 NM_001145309 NM_001145310
Consensus coding sequences : CCDS (NCBI)LRTOMT
Gene ExpressionLRTOMT [ NCBI-GEO ]   LRTOMT [ EBI - ARRAY_EXPRESS ]   LRTOMT [ SEEK ]   LRTOMT [ MEM ]
Gene Expression Viewer (FireBrowse)LRTOMT [ Firebrowse - Broad ]
GenevisibleExpression of LRTOMT in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)220074
GTEX Portal (Tissue expression)LRTOMT
Human Protein AtlasENSG00000184154-LRTOMT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96E66   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96E66  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96E66
PhosPhoSitePlusQ96E66
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)Leu-rich_rpt    LRR_dom_sf    LRTOMT1   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)LRTOMT
SuperfamilyQ96E66
AlphaFold pdb e-kbQ96E66   
Human Protein Atlas [tissue]ENSG00000184154-LRTOMT [tissue]
HPRD11839
Protein Interaction databases
DIP (DOE-UCLA)Q96E66
IntAct (EBI)Q96E66
BioGRIDLRTOMT
STRING (EMBL)LRTOMT
ZODIACLRTOMT
Ontologies - Pathways
QuickGOQ96E66
Ontology : AmiGOcellular_component  endoplasmic reticulum  plasma membrane  sensory perception of sound  O-methyltransferase activity  integral component of membrane  catechol O-methyltransferase activity  catechol O-methyltransferase activity  methylation  developmental process  neurotransmitter catabolic process  dopamine metabolic process  catecholamine catabolic process  catecholamine catabolic process  auditory receptor cell development  L-dopa O-methyltransferase activity  orcinol O-methyltransferase activity  
Ontology : EGO-EBIcellular_component  endoplasmic reticulum  plasma membrane  sensory perception of sound  O-methyltransferase activity  integral component of membrane  catechol O-methyltransferase activity  catechol O-methyltransferase activity  methylation  developmental process  neurotransmitter catabolic process  dopamine metabolic process  catecholamine catabolic process  catecholamine catabolic process  auditory receptor cell development  L-dopa O-methyltransferase activity  orcinol O-methyltransferase activity  
NDEx NetworkLRTOMT
Atlas of Cancer Signalling NetworkLRTOMT
Wikipedia pathwaysLRTOMT
Orthology - Evolution
OrthoDB220074
GeneTree (enSembl)ENSG00000184154
Phylogenetic Trees/Animal Genes : TreeFamLRTOMT
Homologs : HomoloGeneLRTOMT
Homology/Alignments : Family Browser (UCSC)LRTOMT
Gene fusions - Rearrangements
Fusion : QuiverLRTOMT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRTOMT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRTOMT
dbVarLRTOMT
ClinVarLRTOMT
MonarchLRTOMT
1000_GenomesLRTOMT 
Exome Variant ServerLRTOMT
GNOMAD BrowserENSG00000184154
Varsome BrowserLRTOMT
ACMGLRTOMT variants
VarityQ96E66
Genomic Variants (DGV)LRTOMT [DGVbeta]
DECIPHERLRTOMT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLRTOMT 
Mutations
ICGC Data PortalLRTOMT 
TCGA Data PortalLRTOMT 
Broad Tumor PortalLRTOMT
OASIS PortalLRTOMT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRTOMT  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLRTOMT
Mutations and Diseases : HGMDLRTOMT
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLRTOMT
DgiDB (Drug Gene Interaction Database)LRTOMT
DoCM (Curated mutations)LRTOMT
CIViC (Clinical Interpretations of Variants in Cancer)LRTOMT
Cancer3DLRTOMT
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611451    612414   
Orphanet12047   
DisGeNETLRTOMT
MedgenLRTOMT
Genetic Testing Registry LRTOMT
NextProtQ96E66 [Medical]
GENETestsLRTOMT
Target ValidationLRTOMT
Huge Navigator LRTOMT [HugePedia]
ClinGenLRTOMT
Clinical trials, drugs, therapy
MyCancerGenomeLRTOMT
Protein Interactions : CTDLRTOMT
Pharm GKB GenePA164722133
PharosQ96E66
Clinical trialLRTOMT
Miscellaneous
canSAR (ICR)LRTOMT
HarmonizomeLRTOMT
ARCHS4LRTOMT
DataMed IndexLRTOMT
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLRTOMT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 19:09:43 CET 2022

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