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LRWD1 (leucine-rich repeats and WD repeat domain containing 1)

Identity

Alias_symbol (synonym)DKFZp434K1815
ORCA
CENP-33
Other alias
HGNC (Hugo) LRWD1
LocusID (NCBI) 222229
Atlas_Id 68679
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 102105390 and ends at 102113612 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ELL3 (15q15.3) / LRWD1 (7q22.1)LRWD1 (7q22.1) / CRLF1 (19p13.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LRWD1   21769
Cards
Entrez_Gene (NCBI)LRWD1  222229  leucine-rich repeats and WD repeat domain containing 1
AliasesCENP-33; ORCA
GeneCards (Weizmann)LRWD1
Ensembl hg19 (Hinxton)ENSG00000161036 [Gene_View]  chr7:102105390-102113612 [Contig_View]  LRWD1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000161036 [Gene_View]  chr7:102105390-102113612 [Contig_View]  LRWD1 [Vega]
ICGC DataPortalENSG00000161036
TCGA cBioPortalLRWD1
AceView (NCBI)LRWD1
Genatlas (Paris)LRWD1
WikiGenes222229
SOURCE (Princeton)LRWD1
Genetics Home Reference (NIH)LRWD1
Genomic and cartography
GoldenPath hg19 (UCSC)LRWD1  -     chr7:102105390-102113612 +  7q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LRWD1  -     7q22.1   [Description]    (hg38-Dec_2013)
EnsemblLRWD1 - 7q22.1 [CytoView hg19]  LRWD1 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBILRWD1 [Mapview hg19]  LRWD1 [Mapview hg38]
OMIM615167   
Gene and transcription
Genbank (Entrez)AB209379 AK290967 AK313771 AL133057 BC009436
RefSeq transcript (Entrez)NM_152892
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)LRWD1
Cluster EST : UnigeneHs.274135 [ NCBI ]
CGAP (NCI)Hs.274135
Alternative Splicing GalleryENSG00000161036
Gene ExpressionLRWD1 [ NCBI-GEO ]   LRWD1 [ EBI - ARRAY_EXPRESS ]   LRWD1 [ SEEK ]   LRWD1 [ MEM ]
Gene Expression Viewer (FireBrowse)LRWD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)222229
GTEX Portal (Tissue expression)LRWD1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UFC0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UFC0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UFC0
Splice isoforms : SwissVarQ9UFC0
PhosPhoSitePlusQ9UFC0
Domaine pattern : Prosite (Expaxy)LRR (PS51450)    WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)LRR_8 (PF13855)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam13855    pfam00400   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  WD40 (SM00320)  
Conserved Domain (NCBI)LRWD1
DMDM Disease mutations222229
Blocks (Seattle)LRWD1
SuperfamilyQ9UFC0
Human Protein AtlasENSG00000161036
Peptide AtlasQ9UFC0
HPRD10904
IPIIPI00069309   IPI00555865   IPI00945660   IPI00946148   IPI00944967   IPI00946381   IPI00945971   IPI00945271   
Protein Interaction databases
DIP (DOE-UCLA)Q9UFC0
IntAct (EBI)Q9UFC0
FunCoupENSG00000161036
BioGRIDLRWD1
STRING (EMBL)LRWD1
ZODIACLRWD1
Ontologies - Pathways
QuickGOQ9UFC0
Ontology : AmiGOchromatin binding  protein binding  nucleus  nuclear origin of replication recognition complex  pericentric heterochromatin  cytoplasm  microtubule organizing center  DNA replication initiation  chromatin organization  methyl-CpG binding  chromatin modification  telomeric heterochromatin  methylated histone binding  establishment of protein localization to chromatin  
Ontology : EGO-EBIchromatin binding  protein binding  nucleus  nuclear origin of replication recognition complex  pericentric heterochromatin  cytoplasm  microtubule organizing center  DNA replication initiation  chromatin organization  methyl-CpG binding  chromatin modification  telomeric heterochromatin  methylated histone binding  establishment of protein localization to chromatin  
NDEx NetworkLRWD1
Atlas of Cancer Signalling NetworkLRWD1
Wikipedia pathwaysLRWD1
Orthology - Evolution
OrthoDB222229
GeneTree (enSembl)ENSG00000161036
Phylogenetic Trees/Animal Genes : TreeFamLRWD1
HOVERGENQ9UFC0
HOGENOMQ9UFC0
Homologs : HomoloGeneLRWD1
Homology/Alignments : Family Browser (UCSC)LRWD1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLRWD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LRWD1
dbVarLRWD1
ClinVarLRWD1
1000_GenomesLRWD1 
Exome Variant ServerLRWD1
ExAC (Exome Aggregation Consortium)LRWD1 (select the gene name)
Genetic variants : HAPMAP222229
Genomic Variants (DGV)LRWD1 [DGVbeta]
DECIPHER (Syndromes)7:102105390-102113612  ENSG00000161036
CONAN: Copy Number AnalysisLRWD1 
Mutations
ICGC Data PortalLRWD1 
TCGA Data PortalLRWD1 
Broad Tumor PortalLRWD1
OASIS PortalLRWD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLRWD1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLRWD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LRWD1
DgiDB (Drug Gene Interaction Database)LRWD1
DoCM (Curated mutations)LRWD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LRWD1 (select a term)
intoGenLRWD1
Cancer3DLRWD1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615167   
Orphanet
MedgenLRWD1
Genetic Testing Registry LRWD1
NextProtQ9UFC0 [Medical]
TSGene222229
GENETestsLRWD1
Huge Navigator LRWD1 [HugePedia]
snp3D : Map Gene to Disease222229
BioCentury BCIQLRWD1
ClinGenLRWD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD222229
Chemical/Pharm GKB GenePA162394694
Clinical trialLRWD1
Miscellaneous
canSAR (ICR)LRWD1 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLRWD1
EVEXLRWD1
GoPubMedLRWD1
iHOPLRWD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:27:18 CET 2017

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