LSM10 (LSM10, U7 small nuclear RNA associated)

2009-05-01  

Identity

HGNC
LOCATION
1p34.3
LOCUSID
ALIAS
MST074,MSTP074
FUSION GENES

Other Information

Locus ID:

NCBI: 84967
MIM: 617909
HGNC: 17562
Ensembl: ENSG00000181817

Variants:

dbSNP: 84967
ClinVar: 84967
TCGA: ENSG00000181817
COSMIC: LSM10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181817ENST00000315732Q969L4

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intronless Pre-mRNAREACTOMER-HSA-75067
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAsREACTOMER-HSA-77588
SLBP independent Processing of Histone Pre-mRNAsREACTOMER-HSA-111367

References

Pubmed IDYearTitleCitations
115744792001Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein.80
192779822009The subnuclear organization of histone gene regulatory proteins and 3' end processing factors of normal somatic and embryonic stem cells is compromised in selected human cancer cell types.21
169147502006ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase.19
160876812005Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes.14
282891562017U7 snRNP is recruited to histone pre-mRNA in a FLASH-dependent manner by two separate regions of the stem-loop binding protein.8
318199992020Composition and processing activity of a semi-recombinant holo U7 snRNP.1

Citation

Dessen P

LSM10 (LSM10, U7 small nuclear RNA associated)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50921/lsm10