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LSM14A (LSM14A mRNA processing body assembly factor)

Identity

Alias (NCBI)C19orf13
FAM61A
RAP55
RAP55A
HGNC (Hugo) LSM14A
HGNC Alias symbDKFZP434D1335
RAP55A
RAP55
HGNC Alias nameRNA-associated protein 55
HGNC Previous nameC19orf13
 FAM61A
HGNC Previous namechromosome 19 open reading frame 13
 family with sequence similarity 61, member A
 LSM14 homolog A (SCD6, S. cerevisiae)
 LSM14A, mRNA processing body assembly factor
LocusID (NCBI) 26065
Atlas_Id 54435
Location 19q13.11  [Link to chromosome band 19q13]
Location_base_pair Starts at 34172504 and ends at 34229515 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LSM14A (19q13.11) / ACTN4 (19q13.2)LSM14A (19q13.11) / BRAF (7q34)LSM14A (19q13.11) / DCTN2 (12q13.3)
LSM14A (19q13.11) / LSM14A (19q13.11)LSM14A (19q13.11) / PAG1 (8q21.13)LSM14A (19q13.11) / SIPA1L3 (19q13.13)
LSM14A (19q13.11) / STAG2 (Xq25)NF2 (22q12.2) / LSM14A (19q13.11)SIPA1L3 (19q13.13) / LSM14A (19q13.11)
LSM14A 19q13.11 / BRAF 7q34LSM14A 19q13.11 / ACTN4 19q13.2SIPA1L3 19q13.13 / LSM14A 19q13.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(9;19)(q34;q13) LSM14A/ABL1


External links

 

Nomenclature
HGNC (Hugo)LSM14A   24489
Cards
Entrez_Gene (NCBI)LSM14A    LSM14A mRNA processing body assembly factor
AliasesC19orf13; FAM61A; RAP55; RAP55A
GeneCards (Weizmann)LSM14A
Ensembl hg19 (Hinxton)ENSG00000257103 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000257103 [Gene_View]  ENSG00000257103 [Sequence]  chr19:34172504-34229515 [Contig_View]  LSM14A [Vega]
ICGC DataPortalENSG00000257103
TCGA cBioPortalLSM14A
AceView (NCBI)LSM14A
Genatlas (Paris)LSM14A
SOURCE (Princeton)LSM14A
Genetics Home Reference (NIH)LSM14A
Genomic and cartography
GoldenPath hg38 (UCSC)LSM14A  -     chr19:34172504-34229515 +  19q13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LSM14A  -     19q13.11   [Description]    (hg19-Feb_2009)
GoldenPathLSM14A - 19q13.11 [CytoView hg19]  LSM14A - 19q13.11 [CytoView hg38]
ImmunoBaseENSG00000257103
Genome Data Viewer NCBILSM14A [Mapview hg19]  
OMIM610677   
Gene and transcription
Genbank (Entrez)AB069974 AB069975 AK027369 AK027643 AK127401
RefSeq transcript (Entrez)NM_001114093 NM_001384420 NM_001384421 NM_001384422 NM_001384423 NM_001384424 NM_001384425 NM_001384426 NM_001384427 NM_001384428 NM_001384429 NM_001384430 NM_001384431 NM_001384432 NM_001384433 NM_001384434 NM_001384435 NM_001384436 NM_001384437 NM_015578
Consensus coding sequences : CCDS (NCBI)LSM14A
Gene ExpressionLSM14A [ NCBI-GEO ]   LSM14A [ EBI - ARRAY_EXPRESS ]   LSM14A [ SEEK ]   LSM14A [ MEM ]
Gene Expression Viewer (FireBrowse)LSM14A [ Firebrowse - Broad ]
GenevisibleExpression of LSM14A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26065
GTEX Portal (Tissue expression)LSM14A
Human Protein AtlasENSG00000257103-LSM14A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8ND56   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8ND56  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8ND56
PhosPhoSitePlusQ8ND56
Domaine pattern : Prosite (Expaxy)DFDF (PS51512)    FFD (PS51513)    TFG (PS51536)   
Domains : Interpro (EBI)DFDF    FDF_dom    FFD_box    Lsm14-like_N    LSM_dom_sf    TFG_box   
Domain families : Pfam (Sanger)FDF (PF09532)    LSM14 (PF12701)   
Domain families : Pfam (NCBI)pfam09532    pfam12701   
Domain families : Smart (EMBL)FDF (SM01199)  LSM14 (SM01271)  
Conserved Domain (NCBI)LSM14A
PDB (RSDB)6F9W   
PDB Europe6F9W   
PDB (PDBSum)6F9W   
PDB (IMB)6F9W   
Structural Biology KnowledgeBase6F9W   
SCOP (Structural Classification of Proteins)6F9W   
CATH (Classification of proteins structures)6F9W   
SuperfamilyQ8ND56
AlphaFold pdb e-kbQ8ND56   
Human Protein Atlas [tissue]ENSG00000257103-LSM14A [tissue]
HPRD12697
Protein Interaction databases
DIP (DOE-UCLA)Q8ND56
IntAct (EBI)Q8ND56
BioGRIDLSM14A
STRING (EMBL)LSM14A
ZODIACLSM14A
Ontologies - Pathways
QuickGOQ8ND56
Ontology : AmiGOP-body  P-body  double-stranded DNA binding  RNA binding  double-stranded RNA binding  single-stranded RNA binding  mRNA binding  protein binding  cytoplasm  cytosol  multicellular organism development  cytoplasmic stress granule  negative regulation of translation  P-body assembly  P-body assembly  P-body assembly  stress granule assembly  cytoplasmic ribonucleoprotein granule  RIG-I signaling pathway  positive regulation of type I interferon-mediated signaling pathway  mitotic spindle  mitotic spindle assembly  messenger ribonucleoprotein complex  
Ontology : EGO-EBIP-body  P-body  double-stranded DNA binding  RNA binding  double-stranded RNA binding  single-stranded RNA binding  mRNA binding  protein binding  cytoplasm  cytosol  multicellular organism development  cytoplasmic stress granule  negative regulation of translation  P-body assembly  P-body assembly  P-body assembly  stress granule assembly  cytoplasmic ribonucleoprotein granule  RIG-I signaling pathway  positive regulation of type I interferon-mediated signaling pathway  mitotic spindle  mitotic spindle assembly  messenger ribonucleoprotein complex  
NDEx NetworkLSM14A
Atlas of Cancer Signalling NetworkLSM14A
Wikipedia pathwaysLSM14A
Orthology - Evolution
OrthoDB26065
GeneTree (enSembl)ENSG00000257103
Phylogenetic Trees/Animal Genes : TreeFamLSM14A
Homologs : HomoloGeneLSM14A
Homology/Alignments : Family Browser (UCSC)LSM14A
Gene fusions - Rearrangements
Fusion : MitelmanLSM14A/ACTN4 [19q13.11/19q13.2]  
Fusion : MitelmanLSM14A/SIPA1L3 [19q13.11/19q13.13]  
Fusion : MitelmanSIPA1L3/LSM14A [19q13.13/19q13.11]  
Fusion : QuiverLSM14A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLSM14A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LSM14A
dbVarLSM14A
ClinVarLSM14A
MonarchLSM14A
1000_GenomesLSM14A 
Exome Variant ServerLSM14A
GNOMAD BrowserENSG00000257103
Varsome BrowserLSM14A
ACMGLSM14A variants
VarityQ8ND56
Genomic Variants (DGV)LSM14A [DGVbeta]
DECIPHERLSM14A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLSM14A 
Mutations
ICGC Data PortalLSM14A 
TCGA Data PortalLSM14A 
Broad Tumor PortalLSM14A
OASIS PortalLSM14A [ Somatic mutations - Copy number]
Cancer Gene: CensusLSM14A 
Somatic Mutations in Cancer : COSMICLSM14A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLSM14A
Mutations and Diseases : HGMDLSM14A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLSM14A
DgiDB (Drug Gene Interaction Database)LSM14A
DoCM (Curated mutations)LSM14A
CIViC (Clinical Interpretations of Variants in Cancer)LSM14A
Cancer3DLSM14A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610677   
Orphanet
DisGeNETLSM14A
MedgenLSM14A
Genetic Testing Registry LSM14A
NextProtQ8ND56 [Medical]
GENETestsLSM14A
Target ValidationLSM14A
Huge Navigator LSM14A [HugePedia]
ClinGenLSM14A
Clinical trials, drugs, therapy
MyCancerGenomeLSM14A
Protein Interactions : CTDLSM14A
Pharm GKB GenePA134989467
PharosQ8ND56
Clinical trialLSM14A
Miscellaneous
canSAR (ICR)LSM14A
HarmonizomeLSM14A
DataMed IndexLSM14A
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLSM14A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:17:12 CEST 2021

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