LSM4 (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated)

2007-02-01 Affiliation

Identity

HGNC

LSM4

LOCATION

19p13.11

LOCUSID

25804

ALIAS

GRP,YER112W

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 25804
MIM: 607284
HGNC: 17259
Ensembl: ENSG00000130520

Variants:

dbSNP: 25804
ClinVar: 25804
TCGA: ENSG00000130520
COSMIC: LSM4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000130520	ENST00000252816	U3KQK1
ENSG00000130520	ENST00000593829	Q9Y4Z0
ENSG00000130520	ENST00000594828	V9GZ56
ENSG00000130520	ENST00000600289	M0QXB0

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
RNA degradation	KEGG	ko03018
RNA degradation	KEGG	hsa03018
Spliceosome	KEGG	ko03040
Spliceosome	KEGG	hsa03040
Spliceosome, U4/U6.U5 tri-snRNP	KEGG	hsa_M00354
Lsm 2-8 complex	KEGG	hsa_M00396
Lsm 1-7 complex	KEGG	hsa_M00397
Spliceosome, U4/U6.U5 tri-snRNP	KEGG	M00354
Lsm 2-8 complex	KEGG	M00396
Lsm 1-7 complex	KEGG	M00397
Gene Expression	REACTOME	R-HSA-74160
Processing of Capped Intron-Containing Pre-mRNA	REACTOME	R-HSA-72203
mRNA Splicing	REACTOME	R-HSA-72172
mRNA Splicing - Major Pathway	REACTOME	R-HSA-72163
Deadenylation-dependent mRNA decay	REACTOME	R-HSA-429914
mRNA decay by 5' to 3' exoribonuclease	REACTOME	R-HSA-430039

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
12515382	2002	The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.	181
19240061	2009	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	75
17178857	2006	Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer.	63
24255165	2014	The C-terminal extension of Lsm4 interacts directly with the 3' end of the histone mRNP and is required for efficient histone mRNA degradation.	12
27247266	2016	The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation.	12
15905169	2005	ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4.	11
19088440	2008	LSm4 associates with the plasma membrane and acts as a co-factor in cell volume regulation.	6

Citation

Dessen P

LSM4 (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46135/lsm4