LSM6 (LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated)

2014-11-01  

Identity

HGNC
LSM6
LOCATION
4q31.22
LOCUSID
11157
ALIAS
YDR378C
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11157
MIM: 607286
HGNC: 17017
Ensembl: ENSG00000164167

Variants:

dbSNP: 11157
ClinVar: 11157
TCGA: ENSG00000164167
COSMIC: LSM6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164167ENST00000296581P62312
ENSG00000164167ENST00000502781P62312
ENSG00000164167ENST00000504181P62312
ENSG00000164167ENST00000515311P62312
ENSG00000164167ENST00000649747P62312

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, U4/U6.U5 tri-snRNPKEGGhsa_M00354
Lsm 2-8 complexKEGGhsa_M00396
Lsm 1-7 complexKEGGhsa_M00397
Spliceosome, U4/U6.U5 tri-snRNPKEGGM00354
Lsm 2-8 complexKEGGM00396
Lsm 1-7 complexKEGGM00397
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 5' to 3' exoribonucleaseREACTOMER-HSA-430039

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
125153822002The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.181

Citation

Dessen P

LSM6 (LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68689/lsm6