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LSP1 (lymphocyte specific protein 1)

Identity

Alias (NCBI)WP34
pp52
HGNC (Hugo) LSP1
HGNC Alias symbWP34
LocusID (NCBI) 4046
Atlas_Id 289
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 1853084 and ends at 1892263 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABCC1 (16p13.11) / LSP1 (11p15.5)DHFR (5q14.1) / LSP1 (11p15.5)GCDH (19p13.2) / LSP1 (11p15.5)
KRT12 (17q21.2) / LSP1 (11p15.5)LSP1 (11p15.5) / TNNT3 (11p15.5)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Hairy Cell Leukemia (HCL) and Hairy Cell Leukemia Variant (HCL-V)


External links

 

Nomenclature
HGNC (Hugo)LSP1   6707
Cards
Entrez_Gene (NCBI)LSP1    lymphocyte specific protein 1
AliasesWP34; pp52
GeneCards (Weizmann)LSP1
Ensembl hg19 (Hinxton)ENSG00000130592 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130592 [Gene_View]  ENSG00000130592 [Sequence]  chr11:1853084-1892263 [Contig_View]  LSP1 [Vega]
ICGC DataPortalENSG00000130592
TCGA cBioPortalLSP1
AceView (NCBI)LSP1
Genatlas (Paris)LSP1
SOURCE (Princeton)LSP1
Genetics Home Reference (NIH)LSP1
Genomic and cartography
GoldenPath hg38 (UCSC)LSP1  -     chr11:1853084-1892263 +  11p15.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LSP1  -     11p15.5   [Description]    (hg19-Feb_2009)
GoldenPathLSP1 - 11p15.5 [CytoView hg19]  LSP1 - 11p15.5 [CytoView hg38]
ImmunoBaseENSG00000130592
Genome Data Viewer NCBILSP1 [Mapview hg19]  
OMIM153432   
Gene and transcription
Genbank (Entrez)AI817126 AK056576 AK092071 AK093859 AK129684
RefSeq transcript (Entrez)NM_001013253 NM_001013254 NM_001013255 NM_001242932 NM_001289005 NM_002339
Consensus coding sequences : CCDS (NCBI)LSP1
Gene ExpressionLSP1 [ NCBI-GEO ]   LSP1 [ EBI - ARRAY_EXPRESS ]   LSP1 [ SEEK ]   LSP1 [ MEM ]
Gene Expression Viewer (FireBrowse)LSP1 [ Firebrowse - Broad ]
GenevisibleExpression of LSP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4046
GTEX Portal (Tissue expression)LSP1
Human Protein AtlasENSG00000130592-LSP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33241   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP33241  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP33241
PhosPhoSitePlusP33241
Domains : Interpro (EBI)Caldesmon_LSP    Lymphspecific   
Domain families : Pfam (Sanger)Caldesmon (PF02029)   
Domain families : Pfam (NCBI)pfam02029   
Conserved Domain (NCBI)LSP1
PDB (RSDB)3BH8    4NO0    4NO2   
PDB Europe3BH8    4NO0    4NO2   
PDB (PDBSum)3BH8    4NO0    4NO2   
PDB (IMB)3BH8    4NO0    4NO2   
Structural Biology KnowledgeBase3BH8    4NO0    4NO2   
SCOP (Structural Classification of Proteins)3BH8    4NO0    4NO2   
CATH (Classification of proteins structures)3BH8    4NO0    4NO2   
SuperfamilyP33241
AlphaFold pdb e-kbP33241   
Human Protein Atlas [tissue]ENSG00000130592-LSP1 [tissue]
HPRD01083
Protein Interaction databases
DIP (DOE-UCLA)P33241
IntAct (EBI)P33241
BioGRIDLSP1
STRING (EMBL)LSP1
ZODIACLSP1
Ontologies - Pathways
QuickGOP33241
Ontology : AmiGOactin binding  plasma membrane  chemotaxis  cellular defense response  signal transduction  actin cytoskeleton  membrane  extracellular exosome  cellular response to interleukin-7  
Ontology : EGO-EBIactin binding  plasma membrane  chemotaxis  cellular defense response  signal transduction  actin cytoskeleton  membrane  extracellular exosome  cellular response to interleukin-7  
Pathways : KEGGTuberculosis   
NDEx NetworkLSP1
Atlas of Cancer Signalling NetworkLSP1
Wikipedia pathwaysLSP1
Orthology - Evolution
OrthoDB4046
GeneTree (enSembl)ENSG00000130592
Phylogenetic Trees/Animal Genes : TreeFamLSP1
Homologs : HomoloGeneLSP1
Homology/Alignments : Family Browser (UCSC)LSP1
Gene fusions - Rearrangements
Fusion : QuiverLSP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLSP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LSP1
dbVarLSP1
ClinVarLSP1
MonarchLSP1
1000_GenomesLSP1 
Exome Variant ServerLSP1
GNOMAD BrowserENSG00000130592
Varsome BrowserLSP1
ACMGLSP1 variants
VarityP33241
Genomic Variants (DGV)LSP1 [DGVbeta]
DECIPHERLSP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLSP1 
Mutations
ICGC Data PortalLSP1 
TCGA Data PortalLSP1 
Broad Tumor PortalLSP1
OASIS PortalLSP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLSP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLSP1
Mutations and Diseases : HGMDLSP1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLSP1
DgiDB (Drug Gene Interaction Database)LSP1
DoCM (Curated mutations)LSP1
CIViC (Clinical Interpretations of Variants in Cancer)LSP1
Cancer3DLSP1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM153432   
Orphanet
DisGeNETLSP1
MedgenLSP1
Genetic Testing Registry LSP1
NextProtP33241 [Medical]
GENETestsLSP1
Target ValidationLSP1
Huge Navigator LSP1 [HugePedia]
ClinGenLSP1
Clinical trials, drugs, therapy
MyCancerGenomeLSP1
Protein Interactions : CTDLSP1
Pharm GKB GenePA30472
PharosP33241
Clinical trialLSP1
Miscellaneous
canSAR (ICR)LSP1
HarmonizomeLSP1
DataMed IndexLSP1
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLSP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:17:12 CEST 2021

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