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LSS (lanosterol synthase)

Identity

Alias_symbol (synonym)OSC
Other aliasCTRCT44
HGNC (Hugo) LSS
LocusID (NCBI) 4047
Atlas_Id 55266
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 46188446 and ends at 46228824 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C9orf3 (9q22.32) / LSS (21q22.3)NDE1 (16p13.11) / LSS (21q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LSS   6708
Cards
Entrez_Gene (NCBI)LSS  4047  lanosterol synthase
AliasesCTRCT44; OSC
GeneCards (Weizmann)LSS
Ensembl hg19 (Hinxton)ENSG00000160285 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160285 [Gene_View]  chr21:46188446-46228824 [Contig_View]  LSS [Vega]
ICGC DataPortalENSG00000160285
TCGA cBioPortalLSS
AceView (NCBI)LSS
Genatlas (Paris)LSS
WikiGenes4047
SOURCE (Princeton)LSS
Genetics Home Reference (NIH)LSS
Genomic and cartography
GoldenPath hg38 (UCSC)LSS  -     chr21:46188446-46228824 -  21q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LSS  -     21q22.3   [Description]    (hg19-Feb_2009)
EnsemblLSS - 21q22.3 [CytoView hg19]  LSS - 21q22.3 [CytoView hg38]
Mapping of homologs : NCBILSS [Mapview hg19]  LSS [Mapview hg38]
OMIM600909   616509   
Gene and transcription
Genbank (Entrez)AA922470 AK092334 AK096769 AK098352 AK128839
RefSeq transcript (Entrez)NM_001001438 NM_001145436 NM_001145437 NM_002340
RefSeq genomic (Entrez)NC_000021 NC_018932 NG_011510 NT_187626
Consensus coding sequences : CCDS (NCBI)LSS
Cluster EST : UnigeneHs.596543 [ NCBI ]
CGAP (NCI)Hs.596543
Alternative Splicing GalleryENSG00000160285
Gene ExpressionLSS [ NCBI-GEO ]   LSS [ EBI - ARRAY_EXPRESS ]   LSS [ SEEK ]   LSS [ MEM ]
Gene Expression Viewer (FireBrowse)LSS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4047
GTEX Portal (Tissue expression)LSS
Human Protein AtlasENSG00000160285-LSS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48449   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48449  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48449
Splice isoforms : SwissVarP48449
Catalytic activity : Enzyme5.4.99.7 [ Enzyme-Expasy ]   5.4.99.75.4.99.7 [ IntEnz-EBI ]   5.4.99.7 [ BRENDA ]   5.4.99.7 [ KEGG ]   
PhosPhoSitePlusP48449
Domaine pattern : Prosite (Expaxy)TERPENE_SYNTHASES (PS01074)   
Domains : Interpro (EBI)SQ_cyclase_C    SQ_cyclase_N    Squalene_cyclase    Terpene_synthase_CS    Terpenoid_cyclase/PrenylTrfase   
Domain families : Pfam (Sanger)SQHop_cyclase_C (PF13243)    SQHop_cyclase_N (PF13249)   
Domain families : Pfam (NCBI)pfam13243    pfam13249   
Conserved Domain (NCBI)LSS
DMDM Disease mutations4047
Blocks (Seattle)LSS
PDB (SRS)1W6J    1W6K   
PDB (PDBSum)1W6J    1W6K   
PDB (IMB)1W6J    1W6K   
PDB (RSDB)1W6J    1W6K   
Structural Biology KnowledgeBase1W6J    1W6K   
SCOP (Structural Classification of Proteins)1W6J    1W6K   
CATH (Classification of proteins structures)1W6J    1W6K   
SuperfamilyP48449
Human Protein Atlas [tissue]ENSG00000160285-LSS [tissue]
Peptide AtlasP48449
HPRD02945
IPIIPI00009747   IPI00443397   IPI00384606   IPI00871623   IPI00923487   IPI00792647   IPI00791839   IPI00923506   
Protein Interaction databases
DIP (DOE-UCLA)P48449
IntAct (EBI)P48449
FunCoupENSG00000160285
BioGRIDLSS
STRING (EMBL)LSS
ZODIACLSS
Ontologies - Pathways
QuickGOP48449
Ontology : AmiGOlanosterol synthase activity  lanosterol synthase activity  lanosterol synthase activity  endoplasmic reticulum membrane  lipid particle  steroid biosynthetic process  cholesterol biosynthetic process  cholesterol biosynthetic process  membrane  regulation of protein stability  
Ontology : EGO-EBIlanosterol synthase activity  lanosterol synthase activity  lanosterol synthase activity  endoplasmic reticulum membrane  lipid particle  steroid biosynthetic process  cholesterol biosynthetic process  cholesterol biosynthetic process  membrane  regulation of protein stability  
Pathways : KEGGSteroid biosynthesis   
NDEx NetworkLSS
Atlas of Cancer Signalling NetworkLSS
Wikipedia pathwaysLSS
Orthology - Evolution
OrthoDB4047
GeneTree (enSembl)ENSG00000160285
Phylogenetic Trees/Animal Genes : TreeFamLSS
HOVERGENP48449
HOGENOMP48449
Homologs : HomoloGeneLSS
Homology/Alignments : Family Browser (UCSC)LSS
Gene fusions - Rearrangements
Fusion: Tumor Portal LSS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLSS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LSS
dbVarLSS
ClinVarLSS
1000_GenomesLSS 
Exome Variant ServerLSS
ExAC (Exome Aggregation Consortium)ENSG00000160285
GNOMAD BrowserENSG00000160285
Genetic variants : HAPMAP4047
Genomic Variants (DGV)LSS [DGVbeta]
DECIPHERLSS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLSS 
Mutations
ICGC Data PortalLSS 
TCGA Data PortalLSS 
Broad Tumor PortalLSS
OASIS PortalLSS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLSS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLSS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LSS
DgiDB (Drug Gene Interaction Database)LSS
DoCM (Curated mutations)LSS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LSS (select a term)
intoGenLSS
Cancer3DLSS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600909    616509   
Orphanet14011   
MedgenLSS
Genetic Testing Registry LSS
NextProtP48449 [Medical]
TSGene4047
GENETestsLSS
Target ValidationLSS
Huge Navigator LSS [HugePedia]
snp3D : Map Gene to Disease4047
BioCentury BCIQLSS
ClinGenLSS (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4047
Chemical/Pharm GKB GenePA30473
Clinical trialLSS
Miscellaneous
canSAR (ICR)LSS (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLSS
EVEXLSS
GoPubMedLSS
iHOPLSS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:57:29 CET 2017

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