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LTA4H (leukotriene A4 hydrolase)

Identity

Other alias-
HGNC (Hugo) LTA4H
LocusID (NCBI) 4048
Atlas_Id 41210
Location 12q23.1  [Link to chromosome band 12q23]
Location_base_pair Starts at 96394531 and ends at 96429439 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LTA4H (12q23.1) / ADCY2 (5p15.31)LTA4H (12q23.1) / RPLP2 (11p15.5)RANBP3 (19p13.3) / LTA4H (12q23.1)
WDR17 (4q34.2) / LTA4H (12q23.1)WDR17 4q34.2 / LTA4H 12q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LTA4H   6710
Cards
Entrez_Gene (NCBI)LTA4H  4048  leukotriene A4 hydrolase
Aliases
GeneCards (Weizmann)LTA4H
Ensembl hg19 (Hinxton)ENSG00000111144 [Gene_View]  chr12:96394531-96429439 [Contig_View]  LTA4H [Vega]
Ensembl hg38 (Hinxton)ENSG00000111144 [Gene_View]  chr12:96394531-96429439 [Contig_View]  LTA4H [Vega]
ICGC DataPortalENSG00000111144
TCGA cBioPortalLTA4H
AceView (NCBI)LTA4H
Genatlas (Paris)LTA4H
WikiGenes4048
SOURCE (Princeton)LTA4H
Genetics Home Reference (NIH)LTA4H
Genomic and cartography
GoldenPath hg19 (UCSC)LTA4H  -     chr12:96394531-96429439 -  12q23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LTA4H  -     12q23.1   [Description]    (hg38-Dec_2013)
EnsemblLTA4H - 12q23.1 [CytoView hg19]  LTA4H - 12q23.1 [CytoView hg38]
Mapping of homologs : NCBILTA4H [Mapview hg19]  LTA4H [Mapview hg38]
OMIM151570   
Gene and transcription
Genbank (Entrez)AB209740 AI582379 AK293630 AK298017 AK301308
RefSeq transcript (Entrez)NM_000895 NM_001256643 NM_001256644
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)LTA4H
Cluster EST : UnigeneHs.524648 [ NCBI ]
CGAP (NCI)Hs.524648
Alternative Splicing GalleryENSG00000111144
Gene ExpressionLTA4H [ NCBI-GEO ]   LTA4H [ EBI - ARRAY_EXPRESS ]   LTA4H [ SEEK ]   LTA4H [ MEM ]
Gene Expression Viewer (FireBrowse)LTA4H [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4048
GTEX Portal (Tissue expression)LTA4H
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09960   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09960  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09960
Splice isoforms : SwissVarP09960
Catalytic activity : Enzyme3.3.2.6 [ Enzyme-Expasy ]   3.3.2.63.3.2.6 [ IntEnz-EBI ]   3.3.2.6 [ BRENDA ]   3.3.2.6 [ KEGG ]   
PhosPhoSitePlusP09960
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ARM-type_fold    Leukotriene_A4_hydrolase    Peptidase_M1    Peptidase_M1_C    Peptidase_M1_N   
Domain families : Pfam (Sanger)Leuk-A4-hydro_C (PF09127)    Peptidase_M1 (PF01433)   
Domain families : Pfam (NCBI)pfam09127    pfam01433   
Conserved Domain (NCBI)LTA4H
DMDM Disease mutations4048
Blocks (Seattle)LTA4H
PDB (SRS)1GW6    1H19    1HS6    1SQM    2R59    2VJ8    3B7R    3B7S    3B7T    3B7U    3CHO    3CHP    3CHQ    3CHR    3CHS    3FH5    3FH7    3FH8    3FHE    3FTS    3FTU    3FTV    3FTW    3FTX    3FTY    3FTZ    3FU0    3FU3    3FU5    3FU6    3FUD    3FUE    3FUF    3FUH    3FUI    3FUJ    3FUK    3FUL    3FUM    3FUN    3U9W    4DPR    4L2L    4MKT    4MS6    4R7L    4RSY    4RVB    5AEN   
PDB (PDBSum)1GW6    1H19    1HS6    1SQM    2R59    2VJ8    3B7R    3B7S    3B7T    3B7U    3CHO    3CHP    3CHQ    3CHR    3CHS    3FH5    3FH7    3FH8    3FHE    3FTS    3FTU    3FTV    3FTW    3FTX    3FTY    3FTZ    3FU0    3FU3    3FU5    3FU6    3FUD    3FUE    3FUF    3FUH    3FUI    3FUJ    3FUK    3FUL    3FUM    3FUN    3U9W    4DPR    4L2L    4MKT    4MS6    4R7L    4RSY    4RVB    5AEN   
PDB (IMB)1GW6    1H19    1HS6    1SQM    2R59    2VJ8    3B7R    3B7S    3B7T    3B7U    3CHO    3CHP    3CHQ    3CHR    3CHS    3FH5    3FH7    3FH8    3FHE    3FTS    3FTU    3FTV    3FTW    3FTX    3FTY    3FTZ    3FU0    3FU3    3FU5    3FU6    3FUD    3FUE    3FUF    3FUH    3FUI    3FUJ    3FUK    3FUL    3FUM    3FUN    3U9W    4DPR    4L2L    4MKT    4MS6    4R7L    4RSY    4RVB    5AEN   
PDB (RSDB)1GW6    1H19    1HS6    1SQM    2R59    2VJ8    3B7R    3B7S    3B7T    3B7U    3CHO    3CHP    3CHQ    3CHR    3CHS    3FH5    3FH7    3FH8    3FHE    3FTS    3FTU    3FTV    3FTW    3FTX    3FTY    3FTZ    3FU0    3FU3    3FU5    3FU6    3FUD    3FUE    3FUF    3FUH    3FUI    3FUJ    3FUK    3FUL    3FUM    3FUN    3U9W    4DPR    4L2L    4MKT    4MS6    4R7L    4RSY    4RVB    5AEN   
Structural Biology KnowledgeBase1GW6    1H19    1HS6    1SQM    2R59    2VJ8    3B7R    3B7S    3B7T    3B7U    3CHO    3CHP    3CHQ    3CHR    3CHS    3FH5    3FH7    3FH8    3FHE    3FTS    3FTU    3FTV    3FTW    3FTX    3FTY    3FTZ    3FU0    3FU3    3FU5    3FU6    3FUD    3FUE    3FUF    3FUH    3FUI    3FUJ    3FUK    3FUL    3FUM    3FUN    3U9W    4DPR    4L2L    4MKT    4MS6    4R7L    4RSY    4RVB    5AEN   
SCOP (Structural Classification of Proteins)1GW6    1H19    1HS6    1SQM    2R59    2VJ8    3B7R    3B7S    3B7T    3B7U    3CHO    3CHP    3CHQ    3CHR    3CHS    3FH5    3FH7    3FH8    3FHE    3FTS    3FTU    3FTV    3FTW    3FTX    3FTY    3FTZ    3FU0    3FU3    3FU5    3FU6    3FUD    3FUE    3FUF    3FUH    3FUI    3FUJ    3FUK    3FUL    3FUM    3FUN    3U9W    4DPR    4L2L    4MKT    4MS6    4R7L    4RSY    4RVB    5AEN   
CATH (Classification of proteins structures)1GW6    1H19    1HS6    1SQM    2R59    2VJ8    3B7R    3B7S    3B7T    3B7U    3CHO    3CHP    3CHQ    3CHR    3CHS    3FH5    3FH7    3FH8    3FHE    3FTS    3FTU    3FTV    3FTW    3FTX    3FTY    3FTZ    3FU0    3FU3    3FU5    3FU6    3FUD    3FUE    3FUF    3FUH    3FUI    3FUJ    3FUK    3FUL    3FUM    3FUN    3U9W    4DPR    4L2L    4MKT    4MS6    4R7L    4RSY    4RVB    5AEN   
SuperfamilyP09960
Human Protein AtlasENSG00000111144
Peptide AtlasP09960
HPRD01056
IPIIPI00219077   IPI00514090   IPI00793812   IPI00910018   IPI00790203   
Protein Interaction databases
DIP (DOE-UCLA)P09960
IntAct (EBI)P09960
FunCoupENSG00000111144
BioGRIDLTA4H
STRING (EMBL)LTA4H
ZODIACLTA4H
Ontologies - Pathways
QuickGOP09960
Ontology : AmiGOaminopeptidase activity  epoxide hydrolase activity  epoxide hydrolase activity  leukotriene-A4 hydrolase activity  leukotriene-A4 hydrolase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  plasma membrane  proteolysis  leukotriene metabolic process  inflammatory response  peptidase activity  zinc ion binding  response to zinc ion  leukotriene biosynthetic process  peptide binding  peptide catabolic process  response to peptide hormone  poly(A) RNA binding  Type I pneumocyte differentiation  metalloaminopeptidase activity  extracellular exosome  
Ontology : EGO-EBIaminopeptidase activity  epoxide hydrolase activity  epoxide hydrolase activity  leukotriene-A4 hydrolase activity  leukotriene-A4 hydrolase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  plasma membrane  proteolysis  leukotriene metabolic process  inflammatory response  peptidase activity  zinc ion binding  response to zinc ion  leukotriene biosynthetic process  peptide binding  peptide catabolic process  response to peptide hormone  poly(A) RNA binding  Type I pneumocyte differentiation  metalloaminopeptidase activity  extracellular exosome  
Pathways : KEGGArachidonic acid metabolism   
NDEx NetworkLTA4H
Atlas of Cancer Signalling NetworkLTA4H
Wikipedia pathwaysLTA4H
Orthology - Evolution
OrthoDB4048
GeneTree (enSembl)ENSG00000111144
Phylogenetic Trees/Animal Genes : TreeFamLTA4H
HOVERGENP09960
HOGENOMP09960
Homologs : HomoloGeneLTA4H
Homology/Alignments : Family Browser (UCSC)LTA4H
Gene fusions - Rearrangements
Fusion : MitelmanWDR17/LTA4H [4q34.2/12q23.1]  [t(4;12)(q34;q23)]  
Fusion: TCGAWDR17 4q34.2 LTA4H 12q23.1 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLTA4H [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LTA4H
dbVarLTA4H
ClinVarLTA4H
1000_GenomesLTA4H 
Exome Variant ServerLTA4H
ExAC (Exome Aggregation Consortium)LTA4H (select the gene name)
Genetic variants : HAPMAP4048
Genomic Variants (DGV)LTA4H [DGVbeta]
DECIPHER (Syndromes)12:96394531-96429439  ENSG00000111144
CONAN: Copy Number AnalysisLTA4H 
Mutations
ICGC Data PortalLTA4H 
TCGA Data PortalLTA4H 
Broad Tumor PortalLTA4H
OASIS PortalLTA4H [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLTA4H  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLTA4H
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LTA4H
DgiDB (Drug Gene Interaction Database)LTA4H
DoCM (Curated mutations)LTA4H (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LTA4H (select a term)
intoGenLTA4H
Cancer3DLTA4H(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM151570   
Orphanet
MedgenLTA4H
Genetic Testing Registry LTA4H
NextProtP09960 [Medical]
TSGene4048
GENETestsLTA4H
Huge Navigator LTA4H [HugePedia]
snp3D : Map Gene to Disease4048
BioCentury BCIQLTA4H
ClinGenLTA4H
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4048
Chemical/Pharm GKB GenePA24345
Clinical trialLTA4H
Miscellaneous
canSAR (ICR)LTA4H (select the gene name)
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLTA4H
EVEXLTA4H
GoPubMedLTA4H
iHOPLTA4H
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:13:54 CET 2017

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