Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4048
MIM: 151570
HGNC: 6710
Ensembl: ENSG00000111144
Variants:
dbSNP: 4048
ClinVar: 4048
TCGA: ENSG00000111144
COSMIC: LTA4H
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443450 | Asthma | Disease | ClinicalAnnotation | associated | PD | ||
| PA450546 | montelukast | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37086004 | 2024 | Inhibition of Leukotriene A(4) Hydrolase Suppressed Cartilage Degradation and Synovial Inflammation in a Mouse Model of Experimental Osteoarthritis. | 0 |
| 37086004 | 2024 | Inhibition of Leukotriene A(4) Hydrolase Suppressed Cartilage Degradation and Synovial Inflammation in a Mouse Model of Experimental Osteoarthritis. | 0 |
| 36879040 | 2023 | Leukotriene A4 hydrolase (LTA4H rs17525495) gene polymorphisms and paradoxical reactions in extrapulmonary tuberculosis. | 1 |
| 36923505 | 2023 | LTA4H extensively associates with mRNAs and lncRNAs indicative of its novel regulatory targets. | 1 |
| 36879040 | 2023 | Leukotriene A4 hydrolase (LTA4H rs17525495) gene polymorphisms and paradoxical reactions in extrapulmonary tuberculosis. | 1 |
| 36923505 | 2023 | LTA4H extensively associates with mRNAs and lncRNAs indicative of its novel regulatory targets. | 1 |
| 34595756 | 2021 | LTA4H Prevalence and Mortality in Adult Zambians with Tuberculous Meningitis. | 1 |
| 34694182 | 2021 | Clinical Implications of LTA(4)H Genetic Polymorphism in Patients with Chronic Obstructive Pulmonary Disease. | 0 |
| 34595756 | 2021 | LTA4H Prevalence and Mortality in Adult Zambians with Tuberculous Meningitis. | 1 |
| 34694182 | 2021 | Clinical Implications of LTA(4)H Genetic Polymorphism in Patients with Chronic Obstructive Pulmonary Disease. | 0 |
| 32580506 | 2020 | Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking. | 2 |
| 33329520 | 2020 | Leukotriene A(4) Hydrolase Is a Candidate Predictive Biomarker for Successful Allergen Immunotherapy. | 8 |
| 32580506 | 2020 | Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking. | 2 |
| 33329520 | 2020 | Leukotriene A(4) Hydrolase Is a Candidate Predictive Biomarker for Successful Allergen Immunotherapy. | 8 |
| 30352167 | 2019 | Leukotriene A4 Hydrolase Activation and Leukotriene B4 Production by Eosinophils in Severe Asthma. | 16 |
Citation
Dessen P
LTA4H (leukotriene A4 hydrolase)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/41210/lta4h
