LTA4H (leukotriene A4 hydrolase)

2003-05-01 Affiliation

Identity

HGNC

LTA4H

LOCATION

12q23.1

LOCUSID

4048

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4048
MIM: 151570
HGNC: 6710
Ensembl: ENSG00000111144

Variants:

dbSNP: 4048
ClinVar: 4048
TCGA: ENSG00000111144
COSMIC: LTA4H

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000111144	ENST00000228740	P09960
ENSG00000111144	ENST00000228740	A0A140VK27
ENSG00000111144	ENST00000413268	P09960
ENSG00000111144	ENST00000548852	B4DEH5
ENSG00000111144	ENST00000552789	P09960

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Arachidonic acid metabolism	KEGG	ko00590
Arachidonic acid metabolism	KEGG	hsa00590
Metabolic pathways	KEGG	hsa01100
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Arachidonic acid metabolism	REACTOME	R-HSA-2142753
Synthesis of Leukotrienes (LT) and Eoxins (EX)	REACTOME	R-HSA-2142691
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA443450	Asthma	Disease	ClinicalAnnotation	associated		PD
PA450546	montelukast	Chemical	ClinicalAnnotation	associated		PD

References

Pubmed ID	Year	Title	Citations
20211140	2010	The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans.	213
20211140	2010	The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans.	213
23504711	2013	The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype.	86
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
16282974	2006	A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction.	82
16293801	2006	Influence of leukotriene pathway polymorphisms on response to montelukast in asthma.	64
16698924	2006	Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability.	40
15886380	2005	Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial.	36
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
28419368	2017	Leukotriene A4 Hydrolase Genotype and HIV Infection Influence Intracerebral Inflammation and Survival From Tuberculous Meningitis.	24

Citation

Dessen P

LTA4H (leukotriene A4 hydrolase)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41210/lta4h