Atlas of Genetics and Cytogenetics in Oncology and Haematology


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LTA4H (leukotriene A4 hydrolase)

Identity

Alias (NCBI)-
HGNC (Hugo) LTA4H
LocusID (NCBI) 4048
Atlas_Id 41210
Location 12q23.1  [Link to chromosome band 12q23]
Location_base_pair Starts at 96000753 and ends at 96043520 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LTA4H (12q23.1) / ADCY2 (5p15.31)LTA4H (12q23.1) / RPLP2 (11p15.5)RANBP3 (19p13.3) / LTA4H (12q23.1)
WDR17 (4q34.2) / LTA4H (12q23.1)WDR17 4q34.2 / LTA4H 12q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)LTA4H   6710
Cards
Entrez_Gene (NCBI)LTA4H    leukotriene A4 hydrolase
Aliases
GeneCards (Weizmann)LTA4H
Ensembl hg19 (Hinxton)ENSG00000111144 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111144 [Gene_View]  ENSG00000111144 [Sequence]  chr12:96000753-96043520 [Contig_View]  LTA4H [Vega]
ICGC DataPortalENSG00000111144
TCGA cBioPortalLTA4H
AceView (NCBI)LTA4H
Genatlas (Paris)LTA4H
SOURCE (Princeton)LTA4H
Genetics Home Reference (NIH)LTA4H
Genomic and cartography
GoldenPath hg38 (UCSC)LTA4H  -     chr12:96000753-96043520 -  12q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LTA4H  -     12q23.1   [Description]    (hg19-Feb_2009)
GoldenPathLTA4H - 12q23.1 [CytoView hg19]  LTA4H - 12q23.1 [CytoView hg38]
ImmunoBaseENSG00000111144
Genome Data Viewer NCBILTA4H [Mapview hg19]  
OMIM151570   
Gene and transcription
Genbank (Entrez)AB209740 AI582379 AK293630 AK298017 AK301308
RefSeq transcript (Entrez)NM_000895 NM_001256643 NM_001256644
Consensus coding sequences : CCDS (NCBI)LTA4H
Gene ExpressionLTA4H [ NCBI-GEO ]   LTA4H [ EBI - ARRAY_EXPRESS ]   LTA4H [ SEEK ]   LTA4H [ MEM ]
Gene Expression Viewer (FireBrowse)LTA4H [ Firebrowse - Broad ]
GenevisibleExpression of LTA4H in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4048
GTEX Portal (Tissue expression)LTA4H
Human Protein AtlasENSG00000111144-LTA4H [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09960   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09960  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09960
PhosPhoSitePlusP09960
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Aminopeptidase_N-like_N    ARM-type_fold    LTA4H    M1_LTA-4_hydro/amino_C_sf    M1_LTA4H    Peptidase_M1    Peptidase_M1_C    Peptidase_M1_dom    Peptidase_M4/M1_CTD_sf   
Domain families : Pfam (Sanger)Leuk-A4-hydro_C (PF09127)    Peptidase_M1 (PF01433)   
Domain families : Pfam (NCBI)pfam09127    pfam01433   
Domain families : Smart (EMBL)Leuk-A4-hydro_C (SM01263)  
Conserved Domain (NCBI)LTA4H
PDB (RSDB)1GW6    1H19    1HS6    1SQM    2R59    2VJ8    3B7R    3B7S    3B7T    3B7U    3CHO    3CHP    3CHQ    3CHR    3CHS    3FH5    3FH7    3FH8    3FHE    3FTS    3FTU    3FTV    3FTW    3FTX    3FTY    3FTZ    3FU0    3FU3    3FU5    3FU6    3FUD    3FUE    3FUF    3FUH    3FUI    3FUJ    3FUK    3FUL    3FUM    3FUN    3U9W    4DPR    4L2L    4MKT    4MS6    4R7L    4RSY    4RVB    5AEN    5BPP    5FWQ    5N3W    5NI2    5NI4    5NI6    5NIA    5NID    5NIE    6ENB    6ENC    6END    6O5H   
PDB Europe1GW6    1H19    1HS6    1SQM    2R59    2VJ8    3B7R    3B7S    3B7T    3B7U    3CHO    3CHP    3CHQ    3CHR    3CHS    3FH5    3FH7    3FH8    3FHE    3FTS    3FTU    3FTV    3FTW    3FTX    3FTY    3FTZ    3FU0    3FU3    3FU5    3FU6    3FUD    3FUE    3FUF    3FUH    3FUI    3FUJ    3FUK    3FUL    3FUM    3FUN    3U9W    4DPR    4L2L    4MKT    4MS6    4R7L    4RSY    4RVB    5AEN    5BPP    5FWQ    5N3W    5NI2    5NI4    5NI6    5NIA    5NID    5NIE    6ENB    6ENC    6END    6O5H   
PDB (PDBSum)1GW6    1H19    1HS6    1SQM    2R59    2VJ8    3B7R    3B7S    3B7T    3B7U    3CHO    3CHP    3CHQ    3CHR    3CHS    3FH5    3FH7    3FH8    3FHE    3FTS    3FTU    3FTV    3FTW    3FTX    3FTY    3FTZ    3FU0    3FU3    3FU5    3FU6    3FUD    3FUE    3FUF    3FUH    3FUI    3FUJ    3FUK    3FUL    3FUM    3FUN    3U9W    4DPR    4L2L    4MKT    4MS6    4R7L    4RSY    4RVB    5AEN    5BPP    5FWQ    5N3W    5NI2    5NI4    5NI6    5NIA    5NID    5NIE    6ENB    6ENC    6END    6O5H   
PDB (IMB)1GW6    1H19    1HS6    1SQM    2R59    2VJ8    3B7R    3B7S    3B7T    3B7U    3CHO    3CHP    3CHQ    3CHR    3CHS    3FH5    3FH7    3FH8    3FHE    3FTS    3FTU    3FTV    3FTW    3FTX    3FTY    3FTZ    3FU0    3FU3    3FU5    3FU6    3FUD    3FUE    3FUF    3FUH    3FUI    3FUJ    3FUK    3FUL    3FUM    3FUN    3U9W    4DPR    4L2L    4MKT    4MS6    4R7L    4RSY    4RVB    5AEN    5BPP    5FWQ    5N3W    5NI2    5NI4    5NI6    5NIA    5NID    5NIE    6ENB    6ENC    6END    6O5H   
Structural Biology KnowledgeBase1GW6    1H19    1HS6    1SQM    2R59    2VJ8    3B7R    3B7S    3B7T    3B7U    3CHO    3CHP    3CHQ    3CHR    3CHS    3FH5    3FH7    3FH8    3FHE    3FTS    3FTU    3FTV    3FTW    3FTX    3FTY    3FTZ    3FU0    3FU3    3FU5    3FU6    3FUD    3FUE    3FUF    3FUH    3FUI    3FUJ    3FUK    3FUL    3FUM    3FUN    3U9W    4DPR    4L2L    4MKT    4MS6    4R7L    4RSY    4RVB    5AEN    5BPP    5FWQ    5N3W    5NI2    5NI4    5NI6    5NIA    5NID    5NIE    6ENB    6ENC    6END    6O5H   
SCOP (Structural Classification of Proteins)1GW6    1H19    1HS6    1SQM    2R59    2VJ8    3B7R    3B7S    3B7T    3B7U    3CHO    3CHP    3CHQ    3CHR    3CHS    3FH5    3FH7    3FH8    3FHE    3FTS    3FTU    3FTV    3FTW    3FTX    3FTY    3FTZ    3FU0    3FU3    3FU5    3FU6    3FUD    3FUE    3FUF    3FUH    3FUI    3FUJ    3FUK    3FUL    3FUM    3FUN    3U9W    4DPR    4L2L    4MKT    4MS6    4R7L    4RSY    4RVB    5AEN    5BPP    5FWQ    5N3W    5NI2    5NI4    5NI6    5NIA    5NID    5NIE    6ENB    6ENC    6END    6O5H   
CATH (Classification of proteins structures)1GW6    1H19    1HS6    1SQM    2R59    2VJ8    3B7R    3B7S    3B7T    3B7U    3CHO    3CHP    3CHQ    3CHR    3CHS    3FH5    3FH7    3FH8    3FHE    3FTS    3FTU    3FTV    3FTW    3FTX    3FTY    3FTZ    3FU0    3FU3    3FU5    3FU6    3FUD    3FUE    3FUF    3FUH    3FUI    3FUJ    3FUK    3FUL    3FUM    3FUN    3U9W    4DPR    4L2L    4MKT    4MS6    4R7L    4RSY    4RVB    5AEN    5BPP    5FWQ    5N3W    5NI2    5NI4    5NI6    5NIA    5NID    5NIE    6ENB    6ENC    6END    6O5H   
SuperfamilyP09960
AlphaFold pdb e-kbP09960   
Human Protein Atlas [tissue]ENSG00000111144-LTA4H [tissue]
HPRD01056
Protein Interaction databases
DIP (DOE-UCLA)P09960
IntAct (EBI)P09960
BioGRIDLTA4H
STRING (EMBL)LTA4H
ZODIACLTA4H
Ontologies - Pathways
QuickGOP09960
Ontology : AmiGORNA binding  aminopeptidase activity  aminopeptidase activity  epoxide hydrolase activity  epoxide hydrolase activity  epoxide hydrolase activity  epoxide hydrolase activity  leukotriene-A4 hydrolase activity  leukotriene-A4 hydrolase activity  protein binding  extracellular region  nucleus  nucleoplasm  cytosol  cytosol  cytosol  proteolysis  leukotriene metabolic process  peptidase activity  zinc ion binding  zinc ion binding  leukotriene biosynthetic process  leukotriene biosynthetic process  leukotriene biosynthetic process  long-chain fatty acid biosynthetic process  peptide catabolic process  peptide catabolic process  neutrophil degranulation  cellular protein metabolic process  tripeptide aminopeptidase activity  metalloaminopeptidase activity  extracellular exosome  tertiary granule lumen  ficolin-1-rich granule lumen  
Ontology : EGO-EBIRNA binding  aminopeptidase activity  aminopeptidase activity  epoxide hydrolase activity  epoxide hydrolase activity  epoxide hydrolase activity  epoxide hydrolase activity  leukotriene-A4 hydrolase activity  leukotriene-A4 hydrolase activity  protein binding  extracellular region  nucleus  nucleoplasm  cytosol  cytosol  cytosol  proteolysis  leukotriene metabolic process  peptidase activity  zinc ion binding  zinc ion binding  leukotriene biosynthetic process  leukotriene biosynthetic process  leukotriene biosynthetic process  long-chain fatty acid biosynthetic process  peptide catabolic process  peptide catabolic process  neutrophil degranulation  cellular protein metabolic process  tripeptide aminopeptidase activity  metalloaminopeptidase activity  extracellular exosome  tertiary granule lumen  ficolin-1-rich granule lumen  
Pathways : KEGGArachidonic acid metabolism   
NDEx NetworkLTA4H
Atlas of Cancer Signalling NetworkLTA4H
Wikipedia pathwaysLTA4H
Orthology - Evolution
OrthoDB4048
GeneTree (enSembl)ENSG00000111144
Phylogenetic Trees/Animal Genes : TreeFamLTA4H
Homologs : HomoloGeneLTA4H
Homology/Alignments : Family Browser (UCSC)LTA4H
Gene fusions - Rearrangements
Fusion : MitelmanWDR17/LTA4H [4q34.2/12q23.1]  
Fusion : QuiverLTA4H
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLTA4H [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LTA4H
dbVarLTA4H
ClinVarLTA4H
MonarchLTA4H
1000_GenomesLTA4H 
Exome Variant ServerLTA4H
GNOMAD BrowserENSG00000111144
Varsome BrowserLTA4H
ACMGLTA4H variants
VarityP09960
Genomic Variants (DGV)LTA4H [DGVbeta]
DECIPHERLTA4H [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLTA4H 
Mutations
ICGC Data PortalLTA4H 
TCGA Data PortalLTA4H 
Broad Tumor PortalLTA4H
OASIS PortalLTA4H [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLTA4H  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLTA4H
Mutations and Diseases : HGMDLTA4H
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLTA4H
DgiDB (Drug Gene Interaction Database)LTA4H
DoCM (Curated mutations)LTA4H
CIViC (Clinical Interpretations of Variants in Cancer)LTA4H
Cancer3DLTA4H
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM151570   
Orphanet
DisGeNETLTA4H
MedgenLTA4H
Genetic Testing Registry LTA4H
NextProtP09960 [Medical]
GENETestsLTA4H
Target ValidationLTA4H
Huge Navigator LTA4H [HugePedia]
ClinGenLTA4H
Clinical trials, drugs, therapy
MyCancerGenomeLTA4H
Protein Interactions : CTDLTA4H
Pharm GKB GenePA24345
Pharm GKB PathwaysPA165947317   
PharosP09960
Clinical trialLTA4H
Miscellaneous
canSAR (ICR)LTA4H
HarmonizomeLTA4H
DataMed IndexLTA4H
Probes
Litterature
PubMed106 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLTA4H
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:17:13 CEST 2021

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