LTB (lymphotoxin beta)

2003-06-01 Affiliation

Identity

HGNC

LTB

LOCATION

6p21.33

LOCUSID

4050

ALIAS

TNFC,TNFSF3,TNLG1C,p33

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4050
MIM: 600978
HGNC: 6711
Ensembl: ENSG00000227507

Variants:

dbSNP: 4050
ClinVar: 4050
TCGA: ENSG00000227507
COSMIC: LTB

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000227507	ENST00000429299	Q06643
ENSG00000227507	ENST00000429299	Q5STB2
ENSG00000227507	ENST00000446745	Q06643

Expression (GTEx)

100

150

200

250

300

350

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Rheumatoid arthritis	KEGG	ko05323
Rheumatoid arthritis	KEGG	hsa05323
NF-kappa B signaling pathway	KEGG	hsa04064
NF-kappa B signaling pathway	KEGG	ko04064
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
TNFR2 non-canonical NF-kB pathway	REACTOME	R-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	REACTOME	R-HSA-5676594

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA443936	Drug Hypersensitivity	Disease	ClinicalAnnotation	associated		PD
PA448004	abacavir	Chemical	ClinicalAnnotation	associated		PD

References

Pubmed ID	Year	Title	Citations
19800575	2009	A lymphotoxin-driven pathway to hepatocellular carcinoma.	138
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19851445	2009	High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.	51
19222863	2009	Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjögren's syndrome in salivary glands of non-obese diabetic mice.	36
18292573	2008	Lymphotoxin-alpha 1 beta 2 and LIGHT induce classical and noncanonical NF-kappa B-dependent proinflammatory gene expression in vascular endothelial cells.	31
17981284	2008	Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic stroke.	22
15248211	2004	Lymphotoxin beta-mediated stimulation of synoviocytes in rheumatoid arthritis.	16
18379788	2008	High levels of Lymphotoxin-Beta (LT-Beta) gene expression in rheumatoid arthritis synovium: clinical and cytokine correlations.	16
19729601	2009	Candidate gene polymorphisms for ischemic stroke.	14
19948975	2009	Integrative predictive model of coronary artery calcification in atherosclerosis.	13

Citation

Dessen P

LTB (lymphotoxin beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41211/ltb