Identity
HGNC
LOCATION
6p21.33
LOCUSID
ALIAS
TNFC,TNFSF3,TNLG1C,p33
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4050
MIM: 600978
HGNC: 6711
Ensembl: ENSG00000227507
Variants:
dbSNP: 4050
ClinVar: 4050
TCGA: ENSG00000227507
COSMIC: LTB
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000227507 | ENST00000429299 | Q06643 |
| ENSG00000227507 | ENST00000429299 | Q5STB2 |
| ENSG00000227507 | ENST00000446745 | Q06643 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443936 | Drug Hypersensitivity | Disease | ClinicalAnnotation | associated | PD | ||
| PA448004 | abacavir | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37919527 | 2024 | Long Non-Coding RNA AL928768.3 Promotes Rheumatoid Arthritis Fibroblast-Like Synoviocytes Proliferation, Invasion and Inflammation, While Inhibits Apoptosis Via Activating Lymphotoxin Beta Mediated NF-κB Signaling Pathway. | 3 |
| 37919527 | 2024 | Long Non-Coding RNA AL928768.3 Promotes Rheumatoid Arthritis Fibroblast-Like Synoviocytes Proliferation, Invasion and Inflammation, While Inhibits Apoptosis Via Activating Lymphotoxin Beta Mediated NF-κB Signaling Pathway. | 3 |
| 35929442 | 2023 | Gastrointestinal Symptom Cluster is Associated With Epigenetic Regulation of Lymphotoxin Beta in Oncology Patients Receiving Chemotherapy. | 1 |
| 36348017 | 2023 | DNA methylation status of the SPHK1 and LTB genes underlies the clinicopathological diversity of non-alcoholic steatohepatitis-related hepatocellular carcinomas. | 0 |
| 35929442 | 2023 | Gastrointestinal Symptom Cluster is Associated With Epigenetic Regulation of Lymphotoxin Beta in Oncology Patients Receiving Chemotherapy. | 1 |
| 36348017 | 2023 | DNA methylation status of the SPHK1 and LTB genes underlies the clinicopathological diversity of non-alcoholic steatohepatitis-related hepatocellular carcinomas. | 0 |
| 28196873 | 2017 | Lymphotoxin-β Interacts with Methylated EGFR to Mediate Acquired Resistance to Cetuximab in Head and Neck Cancer. | 17 |
| 28196873 | 2017 | Lymphotoxin-β Interacts with Methylated EGFR to Mediate Acquired Resistance to Cetuximab in Head and Neck Cancer. | 17 |
| 22294627 | 2012 | Association between genetic variants in the tumour necrosis factor/lymphotoxin α/lymphotoxin β locus and primary Sjogren's syndrome in Scandinavian samples. | 17 |
| 22652080 | 2012 | The multifaceted character of lymphotoxin β in inflammatory myopathies and muscular dystrophies. | 6 |
| 22742857 | 2012 | TNF-inducible expression of lymphotoxin-β in hepatic cells: an essential role for NF-κB and Ets1 transcription factors. | 7 |
| 22294627 | 2012 | Association between genetic variants in the tumour necrosis factor/lymphotoxin α/lymphotoxin β locus and primary Sjogren's syndrome in Scandinavian samples. | 17 |
| 22652080 | 2012 | The multifaceted character of lymphotoxin β in inflammatory myopathies and muscular dystrophies. | 6 |
| 22742857 | 2012 | TNF-inducible expression of lymphotoxin-β in hepatic cells: an essential role for NF-κB and Ets1 transcription factors. | 7 |
| 21211989 | 2011 | Gene expression profile of cytokines in patients with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation with reduced conditioning. | 7 |
Citation
Dessen P
LTB (lymphotoxin beta)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/41211/ltb
