LTB4R2 (leukotriene B4 receptor 2)

2007-02-01  

Identity

HGNC
LOCATION
14q12
LOCUSID
ALIAS
BLT2,BLTR2,JULF2,KPG_004,LTB4-R

Other Information

Locus ID:

NCBI: 56413
MIM: 605773
HGNC: 19260
Ensembl: ENSG00000213906

Variants:

dbSNP: 56413
ClinVar: 56413
TCGA: ENSG00000213906
COSMIC: LTB4R2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213906ENST00000527924E9PIC1
ENSG00000213906ENST00000528054A0A3Q5ACI7
ENSG00000213906ENST00000530080E9PNJ6
ENSG00000213906ENST00000533293Q9NPC1
ENSG00000213906ENST00000543919Q9NPC1

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Eicosanoid ligand-binding receptorsREACTOMER-HSA-391903
Leukotriene receptorsREACTOMER-HSA-391906
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
128955952003BLT1 and BLT2: the leukotriene B(4) receptors.88
188522552009Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis.42
223965442012Leukotriene B4 receptor-2 promotes invasiveness and metastasis of ovarian cancer cells through signal transducer and activator of transcription 3 (STAT3)-dependent up-regulation of matrix metalloproteinase 2.35
254809802015Two distinct leukotriene B4 receptors, BLT1 and BLT2.33
169209862006Leukotriene B4 receptors BLT1 and BLT2: expression and function in human and murine mast cells.28
201947232010Proinflammatory cytokine IL-1beta stimulates IL-8 synthesis in mast cells via a leukotriene B4 receptor 2-linked pathway, contributing to angiogenesis.28
187811732008BLT2 is expressed in PanINs, IPMNs, pancreatic cancer and stimulates tumour cell proliferation.24
197489282010Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway.24
183235122008Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations.21
192866332009Role of the low-affinity leukotriene B4 receptor BLT2 in VEGF-induced angiogenesis.21

Citation

Dessen P

LTB4R2 (leukotriene B4 receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43648/ltb4r2