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LTBR (lymphotoxin beta receptor)

Identity

Alias (NCBI)D12S370
LT-BETA-R
TNF-R-III
TNFCR
TNFR-RP
TNFR2-RP
TNFR3
TNFRSF3
HGNC (Hugo) LTBR
HGNC Alias symbTNFCR
TNFR-RP
TNFR2-RP
TNF-R-III
TNFRSF3
HGNC Alias nameTNFR superfamily, member 3
HGNC Previous nameD12S370
LocusID (NCBI) 4055
Atlas_Id 41216
Location 12p13.31  [Link to chromosome band 12p13]
Location_base_pair Starts at 6384162 and ends at 6391566 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LTBR (12p13.31) / WDTC1 (1p36.11)NSMCE1 (16p12.1) / LTBR (12p13.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)LTBR   6718
Cards
Entrez_Gene (NCBI)LTBR    lymphotoxin beta receptor
AliasesD12S370; LT-BETA-R; TNF-R-III; TNFCR; 
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3
GeneCards (Weizmann)LTBR
Ensembl hg19 (Hinxton)ENSG00000111321 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111321 [Gene_View]  ENSG00000111321 [Sequence]  chr12:6384162-6391566 [Contig_View]  LTBR [Vega]
ICGC DataPortalENSG00000111321
TCGA cBioPortalLTBR
AceView (NCBI)LTBR
Genatlas (Paris)LTBR
SOURCE (Princeton)LTBR
Genetics Home Reference (NIH)LTBR
Genomic and cartography
GoldenPath hg38 (UCSC)LTBR  -     chr12:6384162-6391566 +  12p13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LTBR  -     12p13.31   [Description]    (hg19-Feb_2009)
GoldenPathLTBR - 12p13.31 [CytoView hg19]  LTBR - 12p13.31 [CytoView hg38]
ImmunoBaseENSG00000111321
Genome Data Viewer NCBILTBR [Mapview hg19]  
OMIM600979   
Gene and transcription
Genbank (Entrez)AK027080 AK095418 AK128019 AK293187 BC026262
RefSeq transcript (Entrez)NM_001270987 NM_002342
Consensus coding sequences : CCDS (NCBI)LTBR
Gene ExpressionLTBR [ NCBI-GEO ]   LTBR [ EBI - ARRAY_EXPRESS ]   LTBR [ SEEK ]   LTBR [ MEM ]
Gene Expression Viewer (FireBrowse)LTBR [ Firebrowse - Broad ]
GenevisibleExpression of LTBR in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4055
GTEX Portal (Tissue expression)LTBR
Human Protein AtlasENSG00000111321-LTBR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36941   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36941  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36941
PhosPhoSitePlusP36941
Domaine pattern : Prosite (Expaxy)TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)TNFR/NGFR_Cys_rich_reg    TNFR_3_LTBR    TNFRSF3_N   
Domain families : Pfam (Sanger)TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00020   
Domain families : Smart (EMBL)TNFR (SM00208)  
Conserved Domain (NCBI)LTBR
PDB (RSDB)1RF3    4MXW   
PDB Europe1RF3    4MXW   
PDB (PDBSum)1RF3    4MXW   
PDB (IMB)1RF3    4MXW   
Structural Biology KnowledgeBase1RF3    4MXW   
SCOP (Structural Classification of Proteins)1RF3    4MXW   
CATH (Classification of proteins structures)1RF3    4MXW   
SuperfamilyP36941
AlphaFold pdb e-kbP36941   
Human Protein Atlas [tissue]ENSG00000111321-LTBR [tissue]
HPRD02988
Protein Interaction databases
DIP (DOE-UCLA)P36941
IntAct (EBI)P36941
BioGRIDLTBR
STRING (EMBL)LTBR
ZODIACLTBR
Ontologies - Pathways
QuickGOP36941
Ontology : AmiGOprotein binding  Golgi apparatus  plasma membrane  apoptotic process  immune response  signal transduction  integral component of membrane  ubiquitin protein ligase binding  ubiquitin protein ligase binding  tumor necrosis factor-mediated signaling pathway  identical protein binding  myeloid dendritic cell differentiation  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of JNK cascade  cellular response to mechanical stimulus  positive regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIprotein binding  Golgi apparatus  plasma membrane  apoptotic process  immune response  signal transduction  integral component of membrane  ubiquitin protein ligase binding  ubiquitin protein ligase binding  tumor necrosis factor-mediated signaling pathway  identical protein binding  myeloid dendritic cell differentiation  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of JNK cascade  cellular response to mechanical stimulus  positive regulation of extrinsic apoptotic signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction    NF-kappa B signaling pathway    HIF-1 signaling pathway    Intestinal immune network for IgA production    HTLV-I infection    Viral carcinogenesis   
NDEx NetworkLTBR
Atlas of Cancer Signalling NetworkLTBR
Wikipedia pathwaysLTBR
Orthology - Evolution
OrthoDB4055
GeneTree (enSembl)ENSG00000111321
Phylogenetic Trees/Animal Genes : TreeFamLTBR
Homologs : HomoloGeneLTBR
Homology/Alignments : Family Browser (UCSC)LTBR
Gene fusions - Rearrangements
Fusion : QuiverLTBR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLTBR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LTBR
dbVarLTBR
ClinVarLTBR
MonarchLTBR
1000_GenomesLTBR 
Exome Variant ServerLTBR
GNOMAD BrowserENSG00000111321
Varsome BrowserLTBR
ACMGLTBR variants
VarityP36941
Genomic Variants (DGV)LTBR [DGVbeta]
DECIPHERLTBR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLTBR 
Mutations
ICGC Data PortalLTBR 
TCGA Data PortalLTBR 
Broad Tumor PortalLTBR
OASIS PortalLTBR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLTBR  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLTBR
Mutations and Diseases : HGMDLTBR
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLTBR
DgiDB (Drug Gene Interaction Database)LTBR
DoCM (Curated mutations)LTBR
CIViC (Clinical Interpretations of Variants in Cancer)LTBR
Cancer3DLTBR
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600979   
Orphanet
DisGeNETLTBR
MedgenLTBR
Genetic Testing Registry LTBR
NextProtP36941 [Medical]
GENETestsLTBR
Target ValidationLTBR
Huge Navigator LTBR [HugePedia]
ClinGenLTBR
Clinical trials, drugs, therapy
MyCancerGenomeLTBR
Protein Interactions : CTDLTBR
Pharm GKB GenePA30481
PharosP36941
Clinical trialLTBR
Miscellaneous
canSAR (ICR)LTBR
HarmonizomeLTBR
DataMed IndexLTBR
Probes
Litterature
PubMed107 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLTBR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:17:15 CEST 2021

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