Atlas of Genetics and Cytogenetics in Oncology and Haematology

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LTC4S (leukotriene C4 synthase)

Identity

Other names-
HGNC (Hugo) LTC4S
LocusID (NCBI) 4056
Location 5q35.3
Location_base_pair Starts at 179220986 and ends at 179223513 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LTC4S   6719
Entrez_Gene (NCBI)LTC4S  4056  leukotriene C4 synthase
Cards
GeneCards (Weizmann)LTC4S
Ensembl (Hinxton)ENSG00000213316 [Gene_View]  chr5:179220986-179223513 [Contig_View]  LTC4S [Vega]
AceView (NCBI)LTC4S
Genatlas (Paris)LTC4S
SOURCE (Stanford)NM_145867
Genomic and cartography
GoldenPath (UCSC)LTC4S  -  5q35.3   chr5:179220986-179223513 +  5q35.3   [Description]    (hg19-Feb_2009)
EnsemblLTC4S - 5q35.3 [CytoView]
Mapping of homologs : NCBILTC4S [Mapview]
OMIM246530   614037   
Gene and transcription
Genbank (Entrez)AI480325 AK312033 BC029498 BI597970 BI819419
RefSeq transcript (SRS)NM_145867
RefSeq transcript (Entrez)NM_145867
RefSeq genomic (SRS)AC_000137 NC_000005 NC_018916 NG_028161 NT_023133 NW_001838967 NW_004078025
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NG_028161 NT_023133 NW_001838967 NW_004078025
Consensus coding sequences : CCDS (NCBI)LTC4S
Cluster EST : UnigeneHs.706741 [ SRS ] Hs.706741 [ NCBI ]
CGAP (NCI)Hs.706741
Alternative Splicing : Fast-db (Paris)GSHG0024536
Alternative Splicing GalleryENSG00000213316
Gene ExpressionLTC4S [ NCBI-GEO ]   LTC4S [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16873 (SRS) Q16873 (Uniprot)
NextProtQ16873
With graphics : InterProQ16873
Splice isoforms : SwissVarQ16873(Swissvar)
Domaine pattern : Prosite (SRS)FLAP_GST2_LTC4S (PS01297)   
Domaine pattern : Prosite (Expaxy)FLAP_GST2_LTC4S (PS01297)   
Domains : Interpro (SRS)5_LipOase_AP    FLAP/GST2/LTC4S_CS    MAPEG-like_dom    Membr-assoc_MAPEG   
Domains : Interpro (EBI)5_LipOase_AP    FLAP/GST2/LTC4S_CS    MAPEG-like_dom    Membr-assoc_MAPEG   
Related proteins : CluSTrQ16873
Domain families : Pfam (SRS)MAPEG (PF01124)   
Domain families : Pfam (Sanger)MAPEG (PF01124)   
Domain families : Pfam (NCBI)pfam01124   
DMDM4056
Blocks (Seattle)Q16873
PDB (SRS)2PNO    2UUH    2UUI    3B29    3HKK    3LEO    3PCV   
PDB (PDBSum)2PNO    2UUH    2UUI    3B29    3HKK    3LEO    3PCV   
PDB (IMB)2PNO    2UUH    2UUI    3B29    3HKK    3LEO    3PCV   
PDB (RSDB)2PNO    2UUH    2UUI    3B29    3HKK    3LEO    3PCV   
Human Protein AtlasENSG00000213316
HPRD02004
IPIIPI00004509   IPI00880205   IPI00967009   
Protein Interaction databases
DIP (DOE-UCLA)Q16873
IntAct (EBI)Q16873
FunCoupENSG00000213316
REACTOMELTC4S
Protein Interaction Database4056
BioGRIDLTC4S
InParanoidQ16873
Interologous Interaction database Q16873
IntegromeDBLTC4S
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)LTC4S
SNP (GeneSNP Utah)LTC4S
SNP : HGBaseLTC4S
Genetic variants : HAPMAPLTC4S
Somatic Mutations in Cancer : COSMICLTC4S 
CONAN: Copy Number AnalysisLTC4S 
Mutations and Diseases : HGMDLTC4S
OMIM246530    614037   
GENETests246530    614037   
Disease Genetic AssociationLTC4S
Huge Navigator LTC4S [HugePedia]  LTC4S [HugeCancerGEM]
Genomic VariantsLTC4S  LTC4S [DGVbeta]
snp3D : Map Gene to Disease4056
General knowledge
Homologs : HomoloGeneLTC4S
Homology/Alignments : Family Browser (UCSC)LTC4S
Phylogenetic Trees/Animal Genes : TreeFamLTC4S
Catalytic activity : Enzyme4.4.1.20 [ Enzyme-Expasy ]   4.4.1.20 [ Enzyme-SRS ]   4.4.1.20 [ IntEnz-EBI ]   4.4.1.20 [ BRENDA ]   4.4.1.20 [ KEGG ]   
Chemical/Protein Interactions : CTD4056
Chemical/Pharm GKB GenePA235
Clinical trialLTC4S
Cancer Resource (Charite)ENSG00000213316
Ontology : AmiGOglutathione transferase activity  leukotriene-C4 synthase activity  leukotriene-C4 synthase activity  glutathione peroxidase activity  protein binding  nuclear envelope  nuclear envelope  nuclear outer membrane  endoplasmic reticulum  endoplasmic reticulum membrane  leukotriene metabolic process  glutathione biosynthetic process  enzyme activator activity  lipid binding  response to inorganic substance  integral to membrane  leukotriene biosynthetic process  response to drug  intracellular membrane-bounded organelle  glutathione binding  protein heterodimerization activity  response to axon injury  cellular response to lipopolysaccharide  cellular response to vitamin A  
Ontology : EGO-EBIglutathione transferase activity  leukotriene-C4 synthase activity  leukotriene-C4 synthase activity  glutathione peroxidase activity  protein binding  nuclear envelope  nuclear envelope  nuclear outer membrane  endoplasmic reticulum  endoplasmic reticulum membrane  leukotriene metabolic process  glutathione biosynthetic process  enzyme activator activity  lipid binding  response to inorganic substance  integral to membrane  leukotriene biosynthetic process  response to drug  intracellular membrane-bounded organelle  glutathione binding  protein heterodimerization activity  response to axon injury  cellular response to lipopolysaccharide  cellular response to vitamin A  
Pathways : KEGGArachidonic acid metabolism
Other databases
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
PubGeneLTC4S
iHOPLTC4S
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:35:41 CEST 2013
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