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LTF (lactotransferrin)

Identity

Alias_symbol (synonym)HLF2
Other aliasGIG12
HEL110
LF
HGNC (Hugo) LTF
LocusID (NCBI) 4057
Atlas_Id 41217
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 46436005 and ends at 46463671 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PRR4 (12p13.2) / LTF (3p21.31)SRRM2 (16p13.3) / LTF (3p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LTF   6720
Cards
Entrez_Gene (NCBI)LTF  4057  lactotransferrin
AliasesGIG12; HEL110; HLF2; LF
GeneCards (Weizmann)LTF
Ensembl hg19 (Hinxton)ENSG00000012223 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000012223 [Gene_View]  chr3:46436005-46463671 [Contig_View]  LTF [Vega]
ICGC DataPortalENSG00000012223
TCGA cBioPortalLTF
AceView (NCBI)LTF
Genatlas (Paris)LTF
WikiGenes4057
SOURCE (Princeton)LTF
Genetics Home Reference (NIH)LTF
Genomic and cartography
GoldenPath hg38 (UCSC)LTF  -     chr3:46436005-46463671 -  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LTF  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblLTF - 3p21.31 [CytoView hg19]  LTF - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBILTF [Mapview hg19]  LTF [Mapview hg38]
OMIM150210   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001199149 NM_001321121 NM_001321122 NM_002343
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LTF
Cluster EST : UnigeneHs.529517 [ NCBI ]
CGAP (NCI)Hs.529517
Alternative Splicing GalleryENSG00000012223
Gene ExpressionLTF [ NCBI-GEO ]   LTF [ EBI - ARRAY_EXPRESS ]   LTF [ SEEK ]   LTF [ MEM ]
Gene Expression Viewer (FireBrowse)LTF [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4057
GTEX Portal (Tissue expression)LTF
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02788   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP02788  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP02788
Splice isoforms : SwissVarP02788
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
PhosPhoSitePlusP02788
Domaine pattern : Prosite (Expaxy)TRANSFERRIN_LIKE_1 (PS00205)    TRANSFERRIN_LIKE_2 (PS00206)    TRANSFERRIN_LIKE_3 (PS00207)    TRANSFERRIN_LIKE_4 (PS51408)   
Domains : Interpro (EBI)Lactotransferrin    Transferrin    Transferrin-like_dom    Transferrin_Fe_BS   
Domain families : Pfam (Sanger)Transferrin (PF00405)   
Domain families : Pfam (NCBI)pfam00405   
Domain families : Smart (EMBL)TR_FER (SM00094)  
Conserved Domain (NCBI)LTF
DMDM Disease mutations4057
Blocks (Seattle)LTF
PDB (SRS)1B0L    1BKA    1CB6    1DSN    1EH3    1FCK    1H43    1H44    1H45    1HSE    1L5T    1LCF    1LCT    1LFG    1LFH    1LFI    1LGB    1N76    1SQY    1U62    1VFD    1VFE    1XV4    1XV7    1Z6V    1Z6W    2BJJ    2DP4    2GMC    2GMD    2HD4    2PMS   
PDB (PDBSum)1B0L    1BKA    1CB6    1DSN    1EH3    1FCK    1H43    1H44    1H45    1HSE    1L5T    1LCF    1LCT    1LFG    1LFH    1LFI    1LGB    1N76    1SQY    1U62    1VFD    1VFE    1XV4    1XV7    1Z6V    1Z6W    2BJJ    2DP4    2GMC    2GMD    2HD4    2PMS   
PDB (IMB)1B0L    1BKA    1CB6    1DSN    1EH3    1FCK    1H43    1H44    1H45    1HSE    1L5T    1LCF    1LCT    1LFG    1LFH    1LFI    1LGB    1N76    1SQY    1U62    1VFD    1VFE    1XV4    1XV7    1Z6V    1Z6W    2BJJ    2DP4    2GMC    2GMD    2HD4    2PMS   
PDB (RSDB)1B0L    1BKA    1CB6    1DSN    1EH3    1FCK    1H43    1H44    1H45    1HSE    1L5T    1LCF    1LCT    1LFG    1LFH    1LFI    1LGB    1N76    1SQY    1U62    1VFD    1VFE    1XV4    1XV7    1Z6V    1Z6W    2BJJ    2DP4    2GMC    2GMD    2HD4    2PMS   
Structural Biology KnowledgeBase1B0L    1BKA    1CB6    1DSN    1EH3    1FCK    1H43    1H44    1H45    1HSE    1L5T    1LCF    1LCT    1LFG    1LFH    1LFI    1LGB    1N76    1SQY    1U62    1VFD    1VFE    1XV4    1XV7    1Z6V    1Z6W    2BJJ    2DP4    2GMC    2GMD    2HD4    2PMS   
SCOP (Structural Classification of Proteins)1B0L    1BKA    1CB6    1DSN    1EH3    1FCK    1H43    1H44    1H45    1HSE    1L5T    1LCF    1LCT    1LFG    1LFH    1LFI    1LGB    1N76    1SQY    1U62    1VFD    1VFE    1XV4    1XV7    1Z6V    1Z6W    2BJJ    2DP4    2GMC    2GMD    2HD4    2PMS   
CATH (Classification of proteins structures)1B0L    1BKA    1CB6    1DSN    1EH3    1FCK    1H43    1H44    1H45    1HSE    1L5T    1LCF    1LCT    1LFG    1LFH    1LFI    1LGB    1N76    1SQY    1U62    1VFD    1VFE    1XV4    1XV7    1Z6V    1Z6W    2BJJ    2DP4    2GMC    2GMD    2HD4    2PMS   
SuperfamilyP02788
Human Protein AtlasENSG00000012223
Peptide AtlasP02788
HPRD01028
IPIIPI00298860   IPI00903112   IPI00908908   IPI00925547   IPI00925299   IPI00925519   
Protein Interaction databases
DIP (DOE-UCLA)P02788
IntAct (EBI)P02788
FunCoupENSG00000012223
BioGRIDLTF
STRING (EMBL)LTF
ZODIACLTF
Ontologies - Pathways
QuickGOP02788
Ontology : AmiGOossification  regulation of cytokine production  retina homeostasis  innate immune response in mucosa  DNA binding  serine-type endopeptidase activity  cysteine-type endopeptidase inhibitor activity  iron ion binding  protein binding  extracellular region  extracellular space  nucleus  cytoplasm  transcription, DNA-templated  proteolysis  ion transport  humoral immune response  heparin binding  cell surface  antimicrobial humoral response  antibacterial humoral response  antifungal humoral response  secretory granule  negative regulation of lipopolysaccharide-mediated signaling pathway  regulation of tumor necrosis factor production  negative regulation of ATPase activity  iron assimilation by chelation and transport  positive regulation of osteoblast proliferation  positive regulation of toll-like receptor 4 signaling pathway  specific granule lumen  specific granule  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  protein complex  neutrophil degranulation  protein serine/threonine kinase activator activity  cellular protein metabolic process  negative regulation by host of viral process  negative regulation of viral genome replication  positive regulation of osteoblast differentiation  negative regulation of viral process  positive regulation of NF-kappaB transcription factor activity  bone morphogenesis  extracellular exosome  positive regulation of protein serine/threonine kinase activity  phagocytic vesicle lumen  positive regulation of bone mineralization involved in bone maturation  negative regulation of single-species biofilm formation in or on host organism  positive regulation of chondrocyte proliferation  tertiary granule lumen  negative regulation of cysteine-type endopeptidase activity  negative regulation of tumor necrosis factor (ligand) superfamily member 11 production  negative regulation of osteoclast development  
Ontology : EGO-EBIossification  regulation of cytokine production  retina homeostasis  innate immune response in mucosa  DNA binding  serine-type endopeptidase activity  cysteine-type endopeptidase inhibitor activity  iron ion binding  protein binding  extracellular region  extracellular space  nucleus  cytoplasm  transcription, DNA-templated  proteolysis  ion transport  humoral immune response  heparin binding  cell surface  antimicrobial humoral response  antibacterial humoral response  antifungal humoral response  secretory granule  negative regulation of lipopolysaccharide-mediated signaling pathway  regulation of tumor necrosis factor production  negative regulation of ATPase activity  iron assimilation by chelation and transport  positive regulation of osteoblast proliferation  positive regulation of toll-like receptor 4 signaling pathway  specific granule lumen  specific granule  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  protein complex  neutrophil degranulation  protein serine/threonine kinase activator activity  cellular protein metabolic process  negative regulation by host of viral process  negative regulation of viral genome replication  positive regulation of osteoblast differentiation  negative regulation of viral process  positive regulation of NF-kappaB transcription factor activity  bone morphogenesis  extracellular exosome  positive regulation of protein serine/threonine kinase activity  phagocytic vesicle lumen  positive regulation of bone mineralization involved in bone maturation  negative regulation of single-species biofilm formation in or on host organism  positive regulation of chondrocyte proliferation  tertiary granule lumen  negative regulation of cysteine-type endopeptidase activity  negative regulation of tumor necrosis factor (ligand) superfamily member 11 production  negative regulation of osteoclast development  
Pathways : BIOCARTAAnthrax Toxin Mechanism of Action [Genes]   
NDEx NetworkLTF
Atlas of Cancer Signalling NetworkLTF
Wikipedia pathwaysLTF
Orthology - Evolution
OrthoDB4057
GeneTree (enSembl)ENSG00000012223
Phylogenetic Trees/Animal Genes : TreeFamLTF
HOVERGENP02788
HOGENOMP02788
Homologs : HomoloGeneLTF
Homology/Alignments : Family Browser (UCSC)LTF
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLTF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LTF
dbVarLTF
ClinVarLTF
1000_GenomesLTF 
Exome Variant ServerLTF
ExAC (Exome Aggregation Consortium)LTF (select the gene name)
Genetic variants : HAPMAP4057
Genomic Variants (DGV)LTF [DGVbeta]
DECIPHERLTF [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLTF 
Mutations
ICGC Data PortalLTF 
TCGA Data PortalLTF 
Broad Tumor PortalLTF
OASIS PortalLTF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLTF  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLTF
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LTF
DgiDB (Drug Gene Interaction Database)LTF
DoCM (Curated mutations)LTF (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LTF (select a term)
intoGenLTF
Cancer3DLTF(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM150210   
Orphanet
MedgenLTF
Genetic Testing Registry LTF
NextProtP02788 [Medical]
TSGene4057
GENETestsLTF
Huge Navigator LTF [HugePedia]
snp3D : Map Gene to Disease4057
BioCentury BCIQLTF
ClinGenLTF
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4057
Chemical/Pharm GKB GenePA30482
Clinical trialLTF
Miscellaneous
canSAR (ICR)LTF (select the gene name)
Probes
Litterature
PubMed280 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLTF
EVEXLTF
GoPubMedLTF
iHOPLTF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:23:38 CEST 2017

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