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LTK (leukocyte receptor tyrosine kinase)

Identity

Alias_namesleukocyte tyrosine kinase
Alias_symbol (synonym)TYK1
Other alias
HGNC (Hugo) LTK
LocusID (NCBI) 4058
Atlas_Id 41218
Location 15q15.1  [Link to chromosome band 15q15]
Location_base_pair Starts at 41503642 and ends at 41513887 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
UACA (15q23) / LTK (15q15.1)UACA 15q23 / LTK 15q15.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LTK   6721
Cards
Entrez_Gene (NCBI)LTK  4058  leukocyte receptor tyrosine kinase
AliasesTYK1
GeneCards (Weizmann)LTK
Ensembl hg19 (Hinxton)ENSG00000062524 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000062524 [Gene_View]  chr15:41503642-41513887 [Contig_View]  LTK [Vega]
ICGC DataPortalENSG00000062524
TCGA cBioPortalLTK
AceView (NCBI)LTK
Genatlas (Paris)LTK
WikiGenes4058
SOURCE (Princeton)LTK
Genetics Home Reference (NIH)LTK
Genomic and cartography
GoldenPath hg38 (UCSC)LTK  -     chr15:41503642-41513887 -  15q15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LTK  -     15q15.1   [Description]    (hg19-Feb_2009)
EnsemblLTK - 15q15.1 [CytoView hg19]  LTK - 15q15.1 [CytoView hg38]
Mapping of homologs : NCBILTK [Mapview hg19]  LTK [Mapview hg38]
OMIM151520   
Gene and transcription
Genbank (Entrez)AK296892 AK314006 BC045607 BC143903 BX329448
RefSeq transcript (Entrez)NM_001135685 NM_002344 NM_206961
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LTK
Cluster EST : UnigeneHs.434481 [ NCBI ]
CGAP (NCI)Hs.434481
Alternative Splicing GalleryENSG00000062524
Gene ExpressionLTK [ NCBI-GEO ]   LTK [ EBI - ARRAY_EXPRESS ]   LTK [ SEEK ]   LTK [ MEM ]
Gene Expression Viewer (FireBrowse)LTK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4058
GTEX Portal (Tissue expression)LTK
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29376   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP29376  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP29376
Splice isoforms : SwissVarP29376
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
PhosPhoSitePlusP29376
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_II (PS00239)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_rcpt_2_CS   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07714   
Domain families : Smart (EMBL)TyrKc (SM00219)  
Conserved Domain (NCBI)LTK
DMDM Disease mutations4058
Blocks (Seattle)LTK
SuperfamilyP29376
Human Protein AtlasENSG00000062524
Peptide AtlasP29376
HPRD01052
IPIIPI00021365   IPI00218841   IPI00007716   IPI00218843   IPI00910943   
Protein Interaction databases
DIP (DOE-UCLA)P29376
IntAct (EBI)P29376
FunCoupENSG00000062524
BioGRIDLTK
STRING (EMBL)LTK
ZODIACLTK
Ontologies - Pathways
QuickGOP29376
Ontology : AmiGOprotein kinase activity  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  protein binding  ATP binding  intracellular  plasma membrane  integral component of plasma membrane  protein phosphorylation  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  cell proliferation  positive regulation of cardiac muscle cell apoptotic process  positive regulation of neuron projection development  phosphatidylinositol 3-kinase signaling  membrane  peptidyl-tyrosine phosphorylation  negative regulation of apoptotic process  cellular response to retinoic acid  
Ontology : EGO-EBIprotein kinase activity  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  protein binding  ATP binding  intracellular  plasma membrane  integral component of plasma membrane  protein phosphorylation  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  cell proliferation  positive regulation of cardiac muscle cell apoptotic process  positive regulation of neuron projection development  phosphatidylinositol 3-kinase signaling  membrane  peptidyl-tyrosine phosphorylation  negative regulation of apoptotic process  cellular response to retinoic acid  
NDEx NetworkLTK
Atlas of Cancer Signalling NetworkLTK
Wikipedia pathwaysLTK
Orthology - Evolution
OrthoDB4058
GeneTree (enSembl)ENSG00000062524
Phylogenetic Trees/Animal Genes : TreeFamLTK
HOVERGENP29376
HOGENOMP29376
Homologs : HomoloGeneLTK
Homology/Alignments : Family Browser (UCSC)LTK
Gene fusions - Rearrangements
Fusion : MitelmanUACA/LTK [15q23/15q15.1]  [t(15;15)(q15;q23)]  
Fusion: TCGAUACA 15q23 LTK 15q15.1 THCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLTK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LTK
dbVarLTK
ClinVarLTK
1000_GenomesLTK 
Exome Variant ServerLTK
ExAC (Exome Aggregation Consortium)LTK (select the gene name)
Genetic variants : HAPMAP4058
Genomic Variants (DGV)LTK [DGVbeta]
DECIPHERLTK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLTK 
Mutations
ICGC Data PortalLTK 
TCGA Data PortalLTK 
Broad Tumor PortalLTK
OASIS PortalLTK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLTK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLTK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LTK
DgiDB (Drug Gene Interaction Database)LTK
DoCM (Curated mutations)LTK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LTK (select a term)
intoGenLTK
Cancer3DLTK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM151520   
Orphanet
MedgenLTK
Genetic Testing Registry LTK
NextProtP29376 [Medical]
TSGene4058
GENETestsLTK
Target ValidationLTK
Huge Navigator LTK [HugePedia]
snp3D : Map Gene to Disease4058
BioCentury BCIQLTK
ClinGenLTK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4058
Chemical/Pharm GKB GenePA30483
Clinical trialLTK
Miscellaneous
canSAR (ICR)LTK (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLTK
EVEXLTK
GoPubMedLTK
iHOPLTK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:16:39 CEST 2017

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